S38A5_BOVIN
ID S38A5_BOVIN Reviewed; 478 AA.
AC Q5E9S9; Q0VD33;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Sodium-coupled neutral amino acid transporter 5;
DE AltName: Full=Solute carrier family 38 member 5;
DE AltName: Full=System N transporter 2;
GN Name=SLC38A5; Synonyms=SNAT5;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT "Characterization of 954 bovine full-CDS cDNA sequences.";
RL BMC Genomics 6:166-166(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=Hereford; TISSUE=Thalamus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Functions as a sodium-dependent amino acid transporter which
CC countertransport protons. Mediates the saturable, pH-sensitive, and
CC electrogenic cotransport of several neutral amino acids including
CC glycine, asparagine, alanine, serine, glutamine and histidine with
CC sodium (By similarity). {ECO:0000250}.
CC -!- ACTIVITY REGULATION: Not inhibited by lithium. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5E9S9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5E9S9-2; Sequence=VSP_029701;
CC -!- SIMILARITY: Belongs to the amino acid/polyamine transporter 2 family.
CC {ECO:0000305}.
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DR EMBL; BT020841; AAX08858.1; -; mRNA.
DR EMBL; BC119859; AAI19860.1; -; mRNA.
DR RefSeq; NP_001015580.1; NM_001015580.1. [Q5E9S9-1]
DR RefSeq; XP_010820194.1; XM_010821892.2. [Q5E9S9-2]
DR AlphaFoldDB; Q5E9S9; -.
DR SMR; Q5E9S9; -.
DR STRING; 9913.ENSBTAP00000015740; -.
DR PaxDb; Q5E9S9; -.
DR PRIDE; Q5E9S9; -.
DR Ensembl; ENSBTAT00000015740; ENSBTAP00000015740; ENSBTAG00000011854. [Q5E9S9-2]
DR GeneID; 512495; -.
DR KEGG; bta:512495; -.
DR CTD; 92745; -.
DR VEuPathDB; HostDB:ENSBTAG00000011854; -.
DR eggNOG; KOG1305; Eukaryota.
DR GeneTree; ENSGT00940000161233; -.
DR HOGENOM; CLU_009020_0_2_1; -.
DR InParanoid; Q5E9S9; -.
DR OMA; DSQMAYT; -.
DR OrthoDB; 697331at2759; -.
DR TreeFam; TF328787; -.
DR Proteomes; UP000009136; Chromosome X.
DR Bgee; ENSBTAG00000011854; Expressed in Ammon's horn and 83 other tissues.
DR ExpressionAtlas; Q5E9S9; baseline and differential.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0015187; F:glycine transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015179; F:L-amino acid transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015186; F:L-glutamine transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0003333; P:amino acid transmembrane transport; IBA:GO_Central.
DR GO; GO:0006868; P:glutamine transport; IBA:GO_Central.
DR GO; GO:0015816; P:glycine transport; IBA:GO_Central.
DR GO; GO:0089709; P:L-histidine transmembrane transport; IBA:GO_Central.
DR GO; GO:0032329; P:serine transport; IBA:GO_Central.
DR InterPro; IPR013057; AA_transpt_TM.
DR Pfam; PF01490; Aa_trans; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell membrane; Disulfide bond; Glycoprotein;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..478
FT /note="Sodium-coupled neutral amino acid transporter 5"
FT /id="PRO_0000312114"
FT TOPO_DOM 1..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..80
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 81..93
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 94..114
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 115..131
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 132..152
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 153..172
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 173..193
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 194..198
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..219
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..263
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 264..284
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 285..301
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 302..322
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 323..340
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 341..361
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 362..382
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 383..403
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 404..405
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 406..426
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 427..445
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 446..466
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 467..478
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 232
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 227..253
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT VAR_SEQ 49
FT /note="D -> DQ (in isoform 2)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_029701"
SQ SEQUENCE 478 AA; 51958 MW; EFFE425481F535B6 CRC64;
MAISSAEGME LQDPKMNGAL PGNAVEQEHE GFLPSHSPSP GRKPAQFMDF EGKTSFGMSV
FNLSNAIMGS GILGLAYAMA HTGILLFLAL LLCIALLSSY SIHLLLTCAG VVGIRAYEQL
GQRALGPAGK VVVAAVICLH NVGAMSSYLF IIKSELPLVI ATFLDMDPEG DWFLKGNLLI
IIVSVLIILP LALMRHLGYL GYTSGLSLTC MLFFLISVIY KKFQLGCTVG HNGTAVESKS
SPSLPIHGLN TSCEAQMFTA DSQMFYTVPI MAFAFVCHPE VLPIYTELCR PSKRRMQAVA
NVSIGAMFCM YGLTATFGYL TFYSSVEAEM LHMYSQHDLL ILCVRLAVLL AVTLTVPVVL
FPIRRALQQL LFPSKAFSWP RHVAIALILL VLVNVLVICV PTIRDIFGVI GSTSAPSLIF
ILPSIFYLRI VPSEVEPLYS WPKIQALCFG VLGVLFMAIS LGFMFANWAT GQSHVSGH
