ID   S38A6_DANRE             Reviewed;         449 AA.
AC   Q503G8;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2005, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Probable sodium-coupled neutral amino acid transporter 6;
DE   AltName: Full=Na(+)-coupled neutral amino acid transporter 6;
DE   AltName: Full=Solute carrier family 38 member 6;
GN   Name=slc38a6; ORFNames=zgc:110611;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable sodium-dependent amino acid/proton antiporter, could
CC       be a neuronal transporter for glutamate.
CC       {ECO:0000250|UniProtKB:G3UVW3}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:G3UVW3};
CC       Multi-pass membrane protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the amino acid/polyamine transporter 2 family.
CC       {ECO:0000305}.
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DR   EMBL; BC095334; AAH95334.1; -; mRNA.
DR   RefSeq; NP_001018308.1; NM_001020472.1.
DR   AlphaFoldDB; Q503G8; -.
DR   SMR; Q503G8; -.
DR   STRING; 7955.ENSDARP00000070951; -.
DR   PaxDb; Q503G8; -.
DR   PRIDE; Q503G8; -.
DR   GeneID; 336741; -.
DR   KEGG; dre:336741; -.
DR   CTD; 145389; -.
DR   ZFIN; ZDB-GENE-050522-51; slc38a6.
DR   eggNOG; KOG1305; Eukaryota.
DR   InParanoid; Q503G8; -.
DR   OrthoDB; 697331at2759; -.
DR   PhylomeDB; Q503G8; -.
DR   PRO; PR:Q503G8; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0015179; F:L-amino acid transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0015186; F:L-glutamine transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0003333; P:amino acid transmembrane transport; IBA:GO_Central.
DR   GO; GO:0006868; P:glutamine transport; IBA:GO_Central.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR013057; AA_transpt_TM.
DR   Pfam; PF01490; Aa_trans; 1.
PE   2: Evidence at transcript level;
KW   Amino-acid transport; Cell membrane; Disulfide bond; Glycoprotein;
KW   Ion transport; Membrane; Reference proteome; Sodium; Sodium transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..449
FT                   /note="Probable sodium-coupled neutral amino acid
FT                   transporter 6"
FT                   /id="PRO_0000311423"
FT   TRANSMEM        44..64
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        73..93
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        115..135
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        165..185
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        186..206
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        242..262
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        279..299
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        319..339
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        363..383
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        387..407
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        423..443
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        7
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        218
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        226
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        278
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        213..230
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ   SEQUENCE   449 AA;  49099 MW;  4941CED082259128 CRC64;
     MGRNGANHSI QTVSEYEPIG EDEERTPLLP QGVQTRGSSF MSSAFNLMNA IMGSGILGLS
     YAMANTGTVG FSILLLMVAS LAAYSIHLLL LLCDKTGINS YEALGEKALN RPGKILVACT
     ILIQNIGAMS SYLFILKTEL PAAIIGFMRS DSETSGKWFE NGVTLLILVT VIIVLPLALL
     PKIGFLGYTS SIAFLFMLFF TVVVVVKKWS IPCPLPINST LSLSLNTSEC TAQLFVISSK
     SAYAVPTMAF SFLCHTAVFP IYCELHRPTK RRMQRATNVS IFLSFVVYLI SALFGYLTFY
     SHVGSELLLA YNTYLPRDIL VMSVRLAILL AVLLTVPLIH FPARKAVLML CRGEREFSWL
     SHTLSCFFIL TLVLLLAIFV PDIKNVFGVV GSTTSTCLLF VYPGMFFLRI SSEPIRSFNS
     VGAVFLLVIG LVVGVLSLSV IIVSWVQGP