S38A6_MOUSE
ID S38A6_MOUSE Reviewed; 457 AA.
AC G3UVW3; B2RXN5;
DT 11-NOV-2015, integrated into UniProtKB/Swiss-Prot.
DT 16-NOV-2011, sequence version 1.
DT 03-AUG-2022, entry version 62.
DE RecName: Full=Probable sodium-coupled neutral amino acid transporter 6;
DE AltName: Full=Na(+)-coupled neutral amino acid transporter 6;
DE AltName: Full=Solute carrier family 38 member 6;
GN Name=Slc38a6; Synonyms=Snat6;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-7, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [5]
RP SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=24752331; DOI=10.1371/journal.pone.0095438;
RA Bagchi S., Baomar H.A., Al-Walai S., Al-Sadi S., Fredriksson R.;
RT "Histological analysis of SLC38A6 (SNAT6) expression in mouse brain shows
RT selective expression in excitatory neurons with high expression in the
RT synapses.";
RL PLoS ONE 9:E95438-E95438(2014).
CC -!- FUNCTION: Probable sodium-dependent amino acid/proton antiporter, could
CC be a neuronal transporter for glutamate. {ECO:0000305|PubMed:24752331}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:24752331};
CC Multi-pass membrane protein {ECO:0000255}. Note=Colocalizes with
CC synaptotagmins and SNAP25. {ECO:0000269|PubMed:24752331}.
CC -!- TISSUE SPECIFICITY: Expressed exclusively in neurons and not in
CC astrocytes and glia cells. Highly expressed in the synapse. Highly
CC expressed in glutamatergic neurons. Primarily expressed in excitatory
CC neurons, with some minor expression in inhibitory neurons.
CC {ECO:0000269|PubMed:24752331}.
CC -!- SIMILARITY: Belongs to the amino acid/polyamine transporter 2 family.
CC {ECO:0000305}.
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DR EMBL; AC159813; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466526; EDL36510.1; -; Genomic_DNA.
DR EMBL; BC157917; AAI57918.1; -; mRNA.
DR EMBL; BC157928; AAI57929.1; -; mRNA.
DR CCDS; CCDS49088.1; -.
DR RefSeq; NP_001032806.2; NM_001037717.3.
DR AlphaFoldDB; G3UVW3; -.
DR SMR; G3UVW3; -.
DR STRING; 10090.ENSMUSP00000120810; -.
DR iPTMnet; G3UVW3; -.
DR PhosphoSitePlus; G3UVW3; -.
DR PaxDb; G3UVW3; -.
DR PRIDE; G3UVW3; -.
DR ProteomicsDB; 256681; -.
DR Antibodypedia; 11535; 39 antibodies from 11 providers.
DR Ensembl; ENSMUST00000140523; ENSMUSP00000120810; ENSMUSG00000044712.
DR GeneID; 625098; -.
DR KEGG; mmu:625098; -.
DR UCSC; uc011yns.2; mouse.
DR CTD; 145389; -.
DR MGI; MGI:3648156; Slc38a6.
DR VEuPathDB; HostDB:ENSMUSG00000044712; -.
DR eggNOG; KOG1305; Eukaryota.
DR GeneTree; ENSGT00940000156982; -.
DR HOGENOM; CLU_009020_0_0_1; -.
DR InParanoid; G3UVW3; -.
DR OMA; KARMQNV; -.
DR OrthoDB; 697331at2759; -.
DR PhylomeDB; G3UVW3; -.
DR TreeFam; TF328787; -.
DR BioGRID-ORCS; 625098; 0 hits in 72 CRISPR screens.
DR ChiTaRS; Slc38a6; mouse.
DR PRO; PR:G3UVW3; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; G3UVW3; protein.
DR Bgee; ENSMUSG00000044712; Expressed in morula and 226 other tissues.
DR ExpressionAtlas; G3UVW3; baseline and differential.
DR Genevisible; G3UVW3; MM.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR GO; GO:0015179; F:L-amino acid transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015186; F:L-glutamine transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0003333; P:amino acid transmembrane transport; IBA:GO_Central.
DR GO; GO:0006868; P:glutamine transport; IBA:GO_Central.
DR InterPro; IPR013057; AA_transpt_TM.
DR Pfam; PF01490; Aa_trans; 1.
PE 1: Evidence at protein level;
KW Acetylation; Cell membrane; Disulfide bond; Membrane; Phosphoprotein;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..457
FT /note="Probable sodium-coupled neutral amino acid
FT transporter 6"
FT /id="PRO_0000434577"
FT TRANSMEM 48..68
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 70..90
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 112..132
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 171..191
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 192..212
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 251..271
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 289..309
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 328..348
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 372..392
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 395..415
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 432..452
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZM9"
FT MOD_RES 4
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZM9"
FT MOD_RES 7
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT DISULFID 219..239
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT CONFLICT 345
FT /note="A -> V (in Ref. 3; AAI57918/AAI57929)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 457 AA; 50253 MW; 7D2A6BBEE90C21BF CRC64;
MQASRHSIQA EPGWYVSAQQ PEEAVAADEW SPLLSNEPHR QGSSGASFGL SVFNVMNAIM
GSGILGLAYV MANTGILGFS FLLLFVALLA SYSVHLLLAM CIHTAVTSYE DLGLFAFGLP
GKVVVAGTII IQNIGAMSSY LLIIKTELPA AISEFLPSDH SGSWYLDGQM LLIIICVGIV
FPLSLLPKIG FLGYTSSLSF FFMVFFALVV VIKKWAVPCP VTLDCINEVF QISNATDDCK
PKLFHFSKES VYAIPTMAFS FLCHTSVLPI YCELQSPSKK RMQNVTNTAI ALSFLVYFVS
ALFGYLTFYD KVESELLQGY SKYLPHDVIV MAVKLCILFA VLLTAPLIHF PARKALMMIL
FSNYPFSWIR HSLTTAALNA IIVVLAIYVP DIRNVFGVVG ASTSTCLIFV FPGLFYLKLS
REDFLSWKKL GALFLLLTGA VVGSFSLVLI IFDWVNK
