ID   S38A6_RAT               Reviewed;         457 AA.
AC   Q6WWW3;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Probable sodium-coupled neutral amino acid transporter 6;
DE   AltName: Full=N-system amino acid transporter 1;
DE            Short=NAT-1;
DE   AltName: Full=Na(+)-coupled neutral amino acid transporter 6;
DE   AltName: Full=Solute carrier family 38 member 6;
GN   Name=Slc38a6; Synonyms=Nat1, Snat6;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Varoqui H., Mackenzie B., Morris M., Schafer M.K., Weihe E., Erickson J.D.;
RT   "A new member of the SLC38 family of neutral amino acid transporters.";
RL   Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable sodium-dependent amino acid/proton antiporter, could
CC       be a neuronal transporter for glutamate.
CC       {ECO:0000250|UniProtKB:G3UVW3}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:G3UVW3};
CC       Multi-pass membrane protein {ECO:0000255}. Note=Colocalizes with
CC       synaptotagmins and SNAP25. {ECO:0000250|UniProtKB:G3UVW3}.
CC   -!- SIMILARITY: Belongs to the amino acid/polyamine transporter 2 family.
CC       {ECO:0000305}.
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DR   EMBL; AY266018; AAP91872.1; -; mRNA.
DR   RefSeq; NP_001013117.1; NM_001013099.1.
DR   AlphaFoldDB; Q6WWW3; -.
DR   SMR; Q6WWW3; -.
DR   STRING; 10116.ENSRNOP00000035818; -.
DR   GlyGen; Q6WWW3; 2 sites.
DR   PaxDb; Q6WWW3; -.
DR   GeneID; 299139; -.
DR   KEGG; rno:299139; -.
DR   UCSC; RGD:1310330; rat.
DR   CTD; 145389; -.
DR   RGD; 1310330; Slc38a6.
DR   eggNOG; KOG1305; Eukaryota.
DR   InParanoid; Q6WWW3; -.
DR   OrthoDB; 697331at2759; -.
DR   PhylomeDB; Q6WWW3; -.
DR   PRO; PR:Q6WWW3; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0015179; F:L-amino acid transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0015186; F:L-glutamine transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0003333; P:amino acid transmembrane transport; IBA:GO_Central.
DR   GO; GO:0006868; P:glutamine transport; IBA:GO_Central.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR013057; AA_transpt_TM.
DR   Pfam; PF01490; Aa_trans; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Amino-acid transport; Cell membrane; Disulfide bond;
KW   Glycoprotein; Ion transport; Membrane; Phosphoprotein; Reference proteome;
KW   Sodium; Sodium transport; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..457
FT                   /note="Probable sodium-coupled neutral amino acid
FT                   transporter 6"
FT                   /id="PRO_0000311422"
FT   TRANSMEM        48..68
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        70..90
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        112..132
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        171..191
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        192..212
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        251..271
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        289..309
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        328..348
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        372..392
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        395..415
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        432..452
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8IZM9"
FT   MOD_RES         4
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8IZM9"
FT   MOD_RES         7
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8IZM9"
FT   CARBOHYD        234
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        284
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        219..239
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ   SEQUENCE   457 AA;  50192 MW;  E226D4FD03585151 CRC64;
     MQASRYSIEA EPGWYVSVQQ PEEAVAAEEW SPLLSNEPRR QGSSGASFGL SVFNVMNAIM
     GSGILGLAYV MANTGILGFS FLLLLVALLA SYSVHLLLAM CIHTAVTSYE DLGLFAFGLP
     GKVVVAGTII IQNIGAMSSY LLIIKTELPA AISEVLPSDH SGAWYLDGQM LLIIICVGIV
     FPLSLLPKIG FLGYTSSLSF FFMVFFALVV VIKKWAVPCP LTLNCINAVF QISNATDDCK
     PKLFHFSKES VYAIPTMAFS FLCHTSVLPI YCELRSPSKK RMQNVTNTAI ALSFLVYFVS
     ALFGYLTFYD KVESELLQGY SKYLPHDAAV MAVKLCILFA VLLTVPLIHF PARKALMMIL
     FSNYPFSWIR HSLTTLALNI IIVLLAIYVP DIRNVFGVVG ASTSTCLIFV FPGLFYLKLS
     REDFLSWKKL GALSLLSTGT VVGSFSLVLI ILDWVNK