ID   S38A6_XENTR             Reviewed;         448 AA.
AC   Q28HE5;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Probable sodium-coupled neutral amino acid transporter 6;
DE   AltName: Full=Na(+)-coupled neutral amino acid transporter 6;
DE   AltName: Full=Solute carrier family 38 member 6;
GN   Name=slc38a6; ORFNames=TEgg038h13.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable sodium-dependent amino acid/proton antiporter, could
CC       be a neuronal transporter for glutamate.
CC       {ECO:0000250|UniProtKB:G3UVW3}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:G3UVW3};
CC       Multi-pass membrane protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the amino acid/polyamine transporter 2 family.
CC       {ECO:0000305}.
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DR   EMBL; CR760918; CAJ82301.1; -; mRNA.
DR   RefSeq; NP_001008117.2; NM_001008116.2.
DR   AlphaFoldDB; Q28HE5; -.
DR   SMR; Q28HE5; -.
DR   STRING; 8364.ENSXETP00000031652; -.
DR   PaxDb; Q28HE5; -.
DR   DNASU; 493479; -.
DR   Ensembl; ENSXETT00000031652; ENSXETP00000031652; ENSXETG00000014459.
DR   GeneID; 493479; -.
DR   KEGG; xtr:493479; -.
DR   CTD; 145389; -.
DR   Xenbase; XB-GENE-1016511; slc38a6.
DR   eggNOG; KOG1305; Eukaryota.
DR   HOGENOM; CLU_009020_0_0_1; -.
DR   InParanoid; Q28HE5; -.
DR   OMA; IFIFGYT; -.
DR   OrthoDB; 697331at2759; -.
DR   PhylomeDB; Q28HE5; -.
DR   TreeFam; TF328787; -.
DR   Proteomes; UP000008143; Chromosome 8.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000014459; Expressed in early embryo and 14 other tissues.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0015179; F:L-amino acid transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0015186; F:L-glutamine transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0003333; P:amino acid transmembrane transport; IBA:GO_Central.
DR   GO; GO:0006868; P:glutamine transport; IBA:GO_Central.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR013057; AA_transpt_TM.
DR   Pfam; PF01490; Aa_trans; 1.
PE   2: Evidence at transcript level;
KW   Amino-acid transport; Cell membrane; Disulfide bond; Glycoprotein;
KW   Ion transport; Membrane; Reference proteome; Sodium; Sodium transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..448
FT                   /note="Probable sodium-coupled neutral amino acid
FT                   transporter 6"
FT                   /id="PRO_0000311424"
FT   TRANSMEM        40..60
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        69..89
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        117..137
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        164..184
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        185..205
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        244..264
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        281..301
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        321..341
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        365..385
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        388..408
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        425..445
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..36
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        218
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        228
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        212..232
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ   SEQUENCE   448 AA;  48818 MW;  1087C3393AAC7104 CRC64;
     MQASDSSINT LDGHQVSAGR DESTPLLANS PQRRSSGGTS FGFAVFNLMN AIMGSGILGL
     SYAMAKTGIL GFSALLLIVA LLAAYSIHLL LRMCLLTAVT SYEDLGLYAF GRSGKVLVAC
     TILIQNVGAM SSYLFIIKSE LPAAIASFLP GAQGEPWYLD GRTLLIITSV CIVLPLALLP
     KIGFLGYTSS LSFFFMVYFA VVIVIKKWNI PCPLPPLNHT VTFLQAPNIS ECKPKLFDFS
     KESAFALPTM AFSFLCHTSV LPIYCELKSP SKSKMQNVAN VGIALSFLIY YISALFGYLT
     FYDNVKSELL QGYSKYLPKD VLIITVRLCI LLAVLLTVPL IHFPARKAVM MMFFSRYPFS
     YIRHILVTLV LNIIIVLLAI YVPDMRSVFG VVGSTTSTCL LFVFPGLFYV KLGREDCSSP
     QKFGACGLLV LGICIGACSL TLIIMNLA