ID   S38A7_BOVIN             Reviewed;         463 AA.
AC   A7E3U5;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Putative sodium-coupled neutral amino acid transporter 7;
DE   AltName: Full=Solute carrier family 38 member 7;
GN   Name=SLC38A7; Synonyms=SNAT7;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
CC   -!- FUNCTION: Mediates sodium-dependent transport of amino acids,
CC       preferentially L-glutamine. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}. Note=In neurons, located in soma and axons.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the amino acid/polyamine transporter 2 family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BT030716; ABS45032.1; -; mRNA.
DR   RefSeq; NP_001093825.1; NM_001100355.1.
DR   RefSeq; XP_005218601.1; XM_005218544.3.
DR   RefSeq; XP_015331219.1; XM_015475733.1.
DR   AlphaFoldDB; A7E3U5; -.
DR   SMR; A7E3U5; -.
DR   STRING; 9913.ENSBTAP00000009438; -.
DR   PaxDb; A7E3U5; -.
DR   Ensembl; ENSBTAT00000009438; ENSBTAP00000009438; ENSBTAG00000007170.
DR   GeneID; 513110; -.
DR   KEGG; bta:513110; -.
DR   CTD; 55238; -.
DR   VEuPathDB; HostDB:ENSBTAG00000007170; -.
DR   VGNC; VGNC:34854; SLC38A7.
DR   eggNOG; KOG1305; Eukaryota.
DR   GeneTree; ENSGT00940000158136; -.
DR   HOGENOM; CLU_038973_0_0_1; -.
DR   InParanoid; A7E3U5; -.
DR   OMA; FAFTGHQ; -.
DR   OrthoDB; 697331at2759; -.
DR   TreeFam; TF328787; -.
DR   Proteomes; UP000009136; Chromosome 18.
DR   Bgee; ENSBTAG00000007170; Expressed in monocyte and 104 other tissues.
DR   GO; GO:0030424; C:axon; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0043025; C:neuronal cell body; ISS:UniProtKB.
DR   GO; GO:0015180; F:L-alanine transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0015179; F:L-amino acid transmembrane transporter activity; ISS:UniProtKB.
DR   GO; GO:0015182; F:L-asparagine transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0015183; F:L-aspartate transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0005313; F:L-glutamate transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0015186; F:L-glutamine transmembrane transporter activity; ISS:UniProtKB.
DR   GO; GO:0005290; F:L-histidine transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0015190; F:L-leucine transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0015191; F:L-methionine transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0015194; F:L-serine transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0003333; P:amino acid transmembrane transport; IBA:GO_Central.
DR   GO; GO:0006814; P:sodium ion transport; ISS:UniProtKB.
DR   InterPro; IPR013057; AA_transpt_TM.
DR   Pfam; PF01490; Aa_trans; 1.
PE   2: Evidence at transcript level;
KW   Amino-acid transport; Ion transport; Membrane; Phosphoprotein;
KW   Reference proteome; Sodium; Sodium transport; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..463
FT                   /note="Putative sodium-coupled neutral amino acid
FT                   transporter 7"
FT                   /id="PRO_0000319596"
FT   TRANSMEM        56..76
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        82..102
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        130..150
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        179..199
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        206..226
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        240..260
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        283..303
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        320..340
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        372..392
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        396..416
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        429..449
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         28
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NVC3"
SQ   SEQUENCE   463 AA;  49853 MW;  C0929D8494FAA397 CRC64;
     MAQVSINRDL GEWGLSTDSG ERARLLQSPS VDIAPKSEGE APPGGVGGGT TSTLGAIFIV
     VNACLGAGLL NFPAAFSTAG GVAAGITLQM AMLVFIISGL VILAYCSQAS NERTYQEVVW
     AVCGKLTGVL CEVAIATYTF GTCIAFLIII GDQQDKIIAV MAKEPEGPGG SPWYTDRKFT
     ISLTAFLFIL PLSIPREIGF QKYASFLSVV GTWYVTAIII IKYIWPDKEM TPADILNRPA
     SWIAVFNAMP TICFGFQCHV SSVPVFNSMR QPEVKTWGGV VTAAMVIALA VYMGTGICGF
     LTFGDAVDPD VLLSYPSEDM AVAVARAFII LSVLTSYPIL HFCGRAVIEG LWLRYQGMPV
     EEDVGRERRR RVLQTLVWFL LTLLLALFIP DIGKVISVIG GLAACFIFVF PGLCLIQAKL
     SEMEEVKPAS WWAMVSYGVL LVTLGAFIFG QTTANAIFVD LLA