S38A7_RAT
ID S38A7_RAT Reviewed; 463 AA.
AC Q6JWR2;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Putative sodium-coupled neutral amino acid transporter 7;
DE AltName: Full=Solute carrier family 38 member 7;
GN Name=Slc38a7; Synonyms=Snat7;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley;
RA Morris M., Varoqui H., Erickson J.D.;
RT "A novel amino acid transporter expressed in glutamatergic neurons.";
RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Mediates sodium-dependent transport of amino acids,
CC preferentially L-glutamine. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}. Note=In neurons, located in soma and axons.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the amino acid/polyamine transporter 2 family.
CC {ECO:0000305}.
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DR EMBL; AY294328; AAQ56180.1; -; mRNA.
DR EMBL; BC086369; AAH86369.1; -; mRNA.
DR RefSeq; NP_001003705.1; NM_001003705.2.
DR RefSeq; XP_006255129.1; XM_006255067.2.
DR AlphaFoldDB; Q6JWR2; -.
DR SMR; Q6JWR2; -.
DR STRING; 10116.ENSRNOP00000058216; -.
DR PaxDb; Q6JWR2; -.
DR PRIDE; Q6JWR2; -.
DR Ensembl; ENSRNOT00000061498; ENSRNOP00000058216; ENSRNOG00000012007.
DR GeneID; 291840; -.
DR KEGG; rno:291840; -.
DR UCSC; RGD:1303268; rat.
DR CTD; 55238; -.
DR RGD; 1303268; Slc38a7.
DR eggNOG; KOG1305; Eukaryota.
DR GeneTree; ENSGT00940000158136; -.
DR HOGENOM; CLU_038973_0_0_1; -.
DR InParanoid; Q6JWR2; -.
DR OMA; FAFTGHQ; -.
DR OrthoDB; 697331at2759; -.
DR PhylomeDB; Q6JWR2; -.
DR TreeFam; TF328787; -.
DR PRO; PR:Q6JWR2; -.
DR Proteomes; UP000002494; Chromosome 19.
DR Bgee; ENSRNOG00000012007; Expressed in skeletal muscle tissue and 18 other tissues.
DR Genevisible; Q6JWR2; RN.
DR GO; GO:0030424; C:axon; ISS:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043025; C:neuronal cell body; ISS:UniProtKB.
DR GO; GO:0015180; F:L-alanine transmembrane transporter activity; ISO:RGD.
DR GO; GO:0015179; F:L-amino acid transmembrane transporter activity; ISS:UniProtKB.
DR GO; GO:0015182; F:L-asparagine transmembrane transporter activity; ISO:RGD.
DR GO; GO:0015183; F:L-aspartate transmembrane transporter activity; ISO:RGD.
DR GO; GO:0005313; F:L-glutamate transmembrane transporter activity; ISO:RGD.
DR GO; GO:0015186; F:L-glutamine transmembrane transporter activity; ISS:UniProtKB.
DR GO; GO:0005290; F:L-histidine transmembrane transporter activity; ISO:RGD.
DR GO; GO:0015190; F:L-leucine transmembrane transporter activity; ISO:RGD.
DR GO; GO:0015191; F:L-methionine transmembrane transporter activity; ISO:RGD.
DR GO; GO:0015194; F:L-serine transmembrane transporter activity; ISO:RGD.
DR GO; GO:0003333; P:amino acid transmembrane transport; IBA:GO_Central.
DR GO; GO:0006814; P:sodium ion transport; ISS:UniProtKB.
DR InterPro; IPR013057; AA_transpt_TM.
DR Pfam; PF01490; Aa_trans; 1.
PE 2: Evidence at transcript level;
KW Amino-acid transport; Ion transport; Membrane; Phosphoprotein;
KW Reference proteome; Sodium; Sodium transport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..463
FT /note="Putative sodium-coupled neutral amino acid
FT transporter 7"
FT /id="PRO_0000319600"
FT TRANSMEM 56..76
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 82..102
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 130..150
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 179..199
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 206..226
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 283..303
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 320..340
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 372..392
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 396..416
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 429..449
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOD_RES 28
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NVC3"
SQ SEQUENCE 463 AA; 49846 MW; 3BD84A2B323321AD CRC64;
MAQVSINSDY SEWGSSTDAG ERARLLQSPC VDVVPKREGE ASPGDPDSGT TSTLGAVFIV
VNACLGAGLL NFPAAFSTAG GVAAGIALQM GMLVFIISGL VILAYCSQAS NERTYQEVVW
AVCGKLTGVL CEIAIAVYTF GTCIAFLIII GDQQDKIIAV MAKEPDGASG SPWYTDRKFT
ISLTAFLFIL PLSIPKEIGF QKYASSLSVV GTWYVTAIVI IKYIWPDKEM RPGDILTRPA
SWMAVFNAMP TICFGFQCHV SSVPVFNSMR QPQVKTWGGV VTAAMVIALA VYMGTGICGF
LTFGAAVDPD VLRSYPSEDV AVAVARAFII LSVLTSYPIL HFCGRAVVEG LWLRYKGTPV
EEDVGRERRR RVLQTLVWFL LTLLLALFIP DIGKVISVIG GLAACFIFIF PGLCLIQAKL
SEMEEVKPAS WWALVSYGVL LVTLGAFIFG QTTANAVFVD LLA
