ID   BEST1_CAEEL             Reviewed;         450 AA.
AC   Q17528;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Bestrophin homolog 1;
GN   Name=best-1; ORFNames=B0564.3;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Forms chloride channels. {ECO:0000250}.
CC   -!- SUBUNIT: Forms oligomers. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the bestrophin family. {ECO:0000305}.
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DR   EMBL; Z73422; CAA97765.1; -; Genomic_DNA.
DR   PIR; T18781; T18781.
DR   RefSeq; NP_502523.1; NM_070122.5.
DR   AlphaFoldDB; Q17528; -.
DR   SMR; Q17528; -.
DR   STRING; 6239.B0564.3.1; -.
DR   PaxDb; Q17528; -.
DR   EnsemblMetazoa; B0564.3.1; B0564.3.1; WBGene00007203.
DR   GeneID; 178264; -.
DR   KEGG; cel:CELE_B0564.3; -.
DR   UCSC; B0564.3.1; c. elegans.
DR   CTD; 178264; -.
DR   WormBase; B0564.3; CE05177; WBGene00007203; best-1.
DR   eggNOG; KOG3547; Eukaryota.
DR   GeneTree; ENSGT00970000196575; -.
DR   HOGENOM; CLU_018069_7_1_1; -.
DR   InParanoid; Q17528; -.
DR   OMA; RYCELVQ; -.
DR   OrthoDB; 279144at2759; -.
DR   PhylomeDB; Q17528; -.
DR   Reactome; R-CEL-2672351; Stimuli-sensing channels.
DR   PRO; PR:Q17528; -.
DR   Proteomes; UP000001940; Chromosome IV.
DR   Bgee; WBGene00007203; Expressed in larva and 2 other tissues.
DR   GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005254; F:chloride channel activity; IBA:GO_Central.
DR   InterPro; IPR000615; Bestrophin.
DR   InterPro; IPR021134; Bestrophin/UPF0187.
DR   PANTHER; PTHR10736; PTHR10736; 1.
DR   Pfam; PF01062; Bestrophin; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Chloride; Chloride channel; Ion channel; Ion transport;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..450
FT                   /note="Bestrophin homolog 1"
FT                   /id="PRO_0000143124"
FT   TRANSMEM        28..48
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        73..93
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        239..259
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        275..295
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   450 AA;  53276 MW;  A0FED9A476166AD7 CRC64;
     MTINYHKEIM TSHPWTFFLL LFKWKGSIWK AVYMETIIFL ICYGIISVIY KTAMGESSQR
     TFESLVRYFD KRLSYIPLEF VLGFFVTTVV NRWTKLYQTI GFIDNVGLMA NCYIRGATEK
     ARIYRRNIMR YCELVQILVF RDMSMRTRRR FPTMETVVAA GFMNKHELEL YNSYDTKYNS
     KLGTKYWIPA NWALCMTYKA RKDGYIESDY FKAQMEGEIR TWRTNIEWVC NYDWVPLPLM
     YPQLVCLAVN LYFLVSIIAR QLVIEKHKMV DEVDVYFPVM TFLQFIFYMG WLKVIDVMLN
     PFGEDDDDFE TNALIDRNIT MGLMIADNPM STPELRKDPF YDEVDVPLLY SEESSNIPNH
     HYHGSVSEVR LEQKGNAPVM MMPHSQSAAN LRRMMSFKSV DEDEKDINAF SMSHDDARMR
     NWREVSLDSS FLADLNENKE WKIPTNPQKF