ID   S38A8_MOUSE             Reviewed;         432 AA.
AC   Q5HZH7;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Putative sodium-coupled neutral amino acid transporter 8;
DE   AltName: Full=Solute carrier family 38 member 8;
GN   Name=Slc38a8; Synonyms=Gm587;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Eye;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   TISSUE SPECIFICITY.
RX   PubMed=24045842; DOI=10.1038/ejhg.2013.212;
RA   Perez Y., Gradstein L., Flusser H., Markus B., Cohen I., Langer Y.,
RA   Marcus M., Lifshitz T., Kadir R., Birk O.S.;
RT   "Isolated foveal hypoplasia with secondary nystagmus and low vision is
RT   associated with a homozygous SLC38A8 mutation.";
RL   Eur. J. Hum. Genet. 22:703-706(2014).
CC   -!- FUNCTION: Putative sodium-dependent amino acid/proton antiporter.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in the eye.
CC       {ECO:0000269|PubMed:24045842}.
CC   -!- SIMILARITY: Belongs to the amino acid/polyamine transporter 2 family.
CC       {ECO:0000305}.
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DR   EMBL; BC089013; AAH89013.1; -; mRNA.
DR   CCDS; CCDS22706.1; -.
DR   RefSeq; NP_001009950.1; NM_001009950.1.
DR   AlphaFoldDB; Q5HZH7; -.
DR   SMR; Q5HZH7; -.
DR   STRING; 10090.ENSMUSP00000038438; -.
DR   PhosphoSitePlus; Q5HZH7; -.
DR   PaxDb; Q5HZH7; -.
DR   PRIDE; Q5HZH7; -.
DR   Antibodypedia; 67804; 70 antibodies from 14 providers.
DR   DNASU; 234788; -.
DR   Ensembl; ENSMUST00000036748; ENSMUSP00000038438; ENSMUSG00000034224.
DR   GeneID; 234788; -.
DR   KEGG; mmu:234788; -.
DR   UCSC; uc009npr.1; mouse.
DR   CTD; 146167; -.
DR   MGI; MGI:2685433; Slc38a8.
DR   VEuPathDB; HostDB:ENSMUSG00000034224; -.
DR   eggNOG; KOG1305; Eukaryota.
DR   GeneTree; ENSGT00940000157764; -.
DR   HOGENOM; CLU_038973_0_0_1; -.
DR   InParanoid; Q5HZH7; -.
DR   OMA; LQCHEAC; -.
DR   OrthoDB; 697331at2759; -.
DR   PhylomeDB; Q5HZH7; -.
DR   TreeFam; TF328787; -.
DR   BioGRID-ORCS; 234788; 5 hits in 73 CRISPR screens.
DR   ChiTaRS; Slc38a8; mouse.
DR   PRO; PR:Q5HZH7; -.
DR   Proteomes; UP000000589; Chromosome 8.
DR   RNAct; Q5HZH7; protein.
DR   Bgee; ENSMUSG00000034224; Expressed in secondary oocyte and 20 other tissues.
DR   ExpressionAtlas; Q5HZH7; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015179; F:L-amino acid transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0003333; P:amino acid transmembrane transport; IBA:GO_Central.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR013057; AA_transpt_TM.
DR   Pfam; PF01490; Aa_trans; 1.
PE   2: Evidence at transcript level;
KW   Amino-acid transport; Ion transport; Membrane; Reference proteome; Sodium;
KW   Sodium transport; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..432
FT                   /note="Putative sodium-coupled neutral amino acid
FT                   transporter 8"
FT                   /id="PRO_0000319594"
FT   TRANSMEM        29..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        59..79
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        103..123
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        144..164
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        175..195
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        215..237
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        253..273
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        292..312
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        345..365
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        368..388
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        409..429
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   432 AA;  46898 MW;  A72EC3D43B31A562 CRC64;
     MEGQPRGSRG PLEKPLPAAT HPTLSSLGAV FILLKSALGA GLLNFPWAFY KAGGMLPTFL
     VALVSLVFLI SGLVILGYAA SVSGQTTYQG VVRELCGPAM GKLCEICFLT NLLMISVAFL
     RVIGDQLEKL CDSLLPDAPQ PWYAAQNFTL PLISMLVIFP LSALREIALQ KYTSILGTLA
     ACYLALVITV QYYLWPQGLI RQPGPLLSPS PWTSVFSVFP TICFGFQCHE AAVSIYCSMW
     NQSLSHWTLV SVLSLLACCL VYTLTGVYGF LTFGPEVSAD ILMSYPGNDT AIIVARVLFA
     VSIVTVYPIV LFLGRSVMQD FWKKSYWATR GPPVLADPSG PWVRLPLTFL WVVVTLTMAL
     FLPDLSEIIS IIGGVSSFFI FIFPGLCLIC AVDTEPMGPR VKCCLEAWGI LSVLVGTFIF
     GQSTAVAMVE LL