ID   S38A8_XENTR             Reviewed;         440 AA.
AC   Q28I47;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 54.
DE   RecName: Full=Putative sodium-coupled neutral amino acid transporter 8;
DE   AltName: Full=Solute carrier family 38 member 8;
GN   Name=slc38a8; ORFNames=TEgg011p02.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Putative sodium-dependent amino acid/proton antiporter.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the amino acid/polyamine transporter 2 family.
CC       {ECO:0000305}.
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DR   EMBL; CR760593; CAJ81310.1; -; mRNA.
DR   RefSeq; NP_001037900.1; NM_001044435.1.
DR   RefSeq; XP_017948568.1; XM_018093079.1.
DR   AlphaFoldDB; Q28I47; -.
DR   SMR; Q28I47; -.
DR   Ensembl; ENSXETT00000062833; ENSXETP00000063342; ENSXETG00000033516.
DR   GeneID; 733502; -.
DR   KEGG; xtr:733502; -.
DR   CTD; 146167; -.
DR   Xenbase; XB-GENE-5766974; slc38a8.
DR   InParanoid; Q28I47; -.
DR   OrthoDB; 697331at2759; -.
DR   Proteomes; UP000008143; Chromosome 4.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000021709; Expressed in egg cell and 13 other tissues.
DR   ExpressionAtlas; Q28I47; differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015179; F:L-amino acid transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0003333; P:amino acid transmembrane transport; IBA:GO_Central.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR013057; AA_transpt_TM.
DR   Pfam; PF01490; Aa_trans; 1.
PE   2: Evidence at transcript level;
KW   Amino-acid transport; Ion transport; Membrane; Reference proteome; Sodium;
KW   Sodium transport; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..440
FT                   /note="Putative sodium-coupled neutral amino acid
FT                   transporter 8"
FT                   /id="PRO_0000319595"
FT   TRANSMEM        29..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        58..78
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        100..120
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        156..176
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        183..203
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        223..243
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        255..275
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        300..320
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        350..370
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        373..393
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        418..438
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   440 AA;  48051 MW;  B3926C78D212BB2C CRC64;
     MEELARESIS LLGKSGLEGG TPSLSSMGAI FIMLKSALGA GLLNFPWAFN KVGGMHTAIM
     VELVSLIFLI SGLVILGYAS SLSKHSTYQG VVKDLCGPAI GKLCGICYII NLFMICVAFL
     RVVEDQLEKL CDSIHSNNTL YAMSEVSQSW YMDPRFAITV LCLVIILPLS IPKEISFQKY
     TSILGTLAAC YLTVMIIIKY YVMEHPVLIK HEFSSNAASW ASMFSVVPTI CFGFQCHEAC
     VTIYSSMKNK CLSNWAAVSV VSMLICLLIY SFTGIYGSLT FGEAVAADIL MSYPGNDVAV
     IIARLLFTIS IITIYPIILL LGRCVIQEAW LNHREKSLFV TLTYERCVRV VITVLWILVT
     LLIALFVPDI SEVISVIGGI SAFFIFIFPG LCLVCAVESE PMNTKAKSCL TAWGAISVVC
     GAFVFGQSTT IAVMEIIAKF