S38AA_MOUSE
ID S38AA_MOUSE Reviewed; 1090 AA.
AC Q5I012; A2AMZ5; Q3TVW4; Q641M1; Q80ZZ4; Q8C1Y0; Q8CCR5; Q9D8J3;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2008, sequence version 2.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Putative sodium-coupled neutral amino acid transporter 10;
DE AltName: Full=Solute carrier family 38 member 10;
GN Name=Slc38a10;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3; 5 AND 6).
RC STRAIN=C57BL/6J; TISSUE=Kidney, Olfactory bulb, and Pancreas;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4), AND NUCLEOTIDE
RP SEQUENCE [LARGE SCALE MRNA] OF 353-1090 (ISOFORM 3).
RC STRAIN=C57BL/6J, and FVB/N; TISSUE=Brain, Colon, and Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-441; SER-608 AND SER-636, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen,
RC and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Putative sodium-dependent amino acid/proton antiporter.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=6;
CC Name=1;
CC IsoId=Q5I012-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5I012-2; Sequence=VSP_031333;
CC Name=3;
CC IsoId=Q5I012-3; Sequence=VSP_031332;
CC Name=4;
CC IsoId=Q5I012-4; Sequence=VSP_031332, VSP_031333;
CC Name=5;
CC IsoId=Q5I012-5; Sequence=VSP_031329, VSP_031330;
CC Name=6;
CC IsoId=Q5I012-6; Sequence=VSP_031328, VSP_031331;
CC -!- SIMILARITY: Belongs to the amino acid/polyamine transporter 2 family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH43299.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK007977; BAB25384.1; -; mRNA.
DR EMBL; AK032245; BAC27777.1; -; mRNA.
DR EMBL; AK090050; BAC41066.1; -; mRNA.
DR EMBL; AK159948; BAE35504.1; -; mRNA.
DR EMBL; AL807824; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC043299; AAH43299.1; ALT_INIT; mRNA.
DR EMBL; BC082300; AAH82300.1; -; mRNA.
DR EMBL; BC088811; AAH88811.1; -; mRNA.
DR CCDS; CCDS25728.1; -. [Q5I012-1]
DR CCDS; CCDS49000.1; -. [Q5I012-3]
DR CCDS; CCDS49001.1; -. [Q5I012-5]
DR CCDS; CCDS49002.1; -. [Q5I012-6]
DR RefSeq; NP_001158270.1; NM_001164798.1. [Q5I012-2]
DR RefSeq; NP_001158271.1; NM_001164799.1. [Q5I012-3]
DR RefSeq; NP_001158272.1; NM_001164800.1. [Q5I012-4]
DR RefSeq; NP_001158273.1; NM_001164801.1. [Q5I012-6]
DR RefSeq; NP_001158274.1; NM_001164802.1. [Q5I012-5]
DR RefSeq; NP_077211.4; NM_024249.5. [Q5I012-1]
DR AlphaFoldDB; Q5I012; -.
DR SMR; Q5I012; -.
DR BioGRID; 215121; 3.
DR STRING; 10090.ENSMUSP00000099307; -.
DR iPTMnet; Q5I012; -.
DR PhosphoSitePlus; Q5I012; -.
DR EPD; Q5I012; -.
DR jPOST; Q5I012; -.
DR MaxQB; Q5I012; -.
DR PaxDb; Q5I012; -.
DR PeptideAtlas; Q5I012; -.
DR PRIDE; Q5I012; -.
DR ProteomicsDB; 256893; -. [Q5I012-1]
DR ProteomicsDB; 256894; -. [Q5I012-2]
DR ProteomicsDB; 256895; -. [Q5I012-3]
DR ProteomicsDB; 256896; -. [Q5I012-4]
DR ProteomicsDB; 256897; -. [Q5I012-5]
DR ProteomicsDB; 256898; -. [Q5I012-6]
DR Antibodypedia; 19805; 38 antibodies from 10 providers.
DR DNASU; 72055; -.
DR Ensembl; ENSMUST00000045402; ENSMUSP00000048675; ENSMUSG00000061306. [Q5I012-3]
DR Ensembl; ENSMUST00000053692; ENSMUSP00000057615; ENSMUSG00000061306. [Q5I012-6]
DR Ensembl; ENSMUST00000076697; ENSMUSP00000075989; ENSMUSG00000061306. [Q5I012-5]
DR Ensembl; ENSMUST00000103018; ENSMUSP00000099307; ENSMUSG00000061306. [Q5I012-1]
DR GeneID; 72055; -.
DR KEGG; mmu:72055; -.
DR UCSC; uc007mrv.2; mouse. [Q5I012-1]
DR UCSC; uc007mrw.2; mouse. [Q5I012-3]
DR UCSC; uc007mrx.2; mouse. [Q5I012-2]
DR UCSC; uc007mry.2; mouse. [Q5I012-4]
DR UCSC; uc007mrz.2; mouse. [Q5I012-5]
DR UCSC; uc007msa.2; mouse. [Q5I012-6]
DR CTD; 124565; -.
DR MGI; MGI:1919305; Slc38a10.
DR VEuPathDB; HostDB:ENSMUSG00000061306; -.
DR eggNOG; KOG1305; Eukaryota.
DR GeneTree; ENSGT00940000159369; -.
DR HOGENOM; CLU_009020_6_0_1; -.
DR InParanoid; Q5I012; -.
DR OMA; TITCVIH; -.
DR OrthoDB; 1109791at2759; -.
DR PhylomeDB; Q5I012; -.
DR TreeFam; TF320116; -.
DR BioGRID-ORCS; 72055; 3 hits in 71 CRISPR screens.
DR ChiTaRS; Slc38a10; mouse.
DR PRO; PR:Q5I012; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q5I012; protein.
DR Bgee; ENSMUSG00000061306; Expressed in motor neuron and 278 other tissues.
DR ExpressionAtlas; Q5I012; baseline and differential.
DR Genevisible; Q5I012; MM.
DR GO; GO:0005794; C:Golgi apparatus; ISO:MGI.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015179; F:L-amino acid transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0003333; P:amino acid transmembrane transport; IBA:GO_Central.
DR GO; GO:0060348; P:bone development; IMP:MGI.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR013057; AA_transpt_TM.
DR Pfam; PF01490; Aa_trans; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Amino-acid transport; Ion transport; Membrane;
KW Phosphoprotein; Reference proteome; Sodium; Sodium transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..1090
FT /note="Putative sodium-coupled neutral amino acid
FT transporter 10"
FT /id="PRO_0000318976"
FT TRANSMEM 9..31
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 36..58
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 84..104
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 123..143
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 153..173
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 229..249
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 323..343
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 345..365
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 378..398
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 441..675
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 729..831
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 857..1037
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 442..457
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 496..528
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 542..558
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 654..668
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 729..746
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 883..897
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 958..979
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1006..1033
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 441
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 608
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 636
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 769
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9HBR0"
FT MOD_RES 887
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:E9PT23"
FT VAR_SEQ 378..428
FT /note="VVLWVGLGILVVSTLTTLSVTEEAPLDLTQEARSGHRGDAEGAMKVEAARL
FT -> DLESCRRQPSGRGCLGLSDMGGATLTTVPGPEVRANQRGMSGRAPGFISTC (in
FT isoform 6)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_031328"
FT VAR_SEQ 378..408
FT /note="VVLWVGLGILVVSTLTTLSVTEEAPLDLTQE -> GLPTEPWLSWYSLYRPG
FT WPRTQGSPDSHPEC (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_031329"
FT VAR_SEQ 409..1090
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_031330"
FT VAR_SEQ 429..1090
FT /note="Missing (in isoform 6)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_031331"
FT VAR_SEQ 678..685
FT /note="Missing (in isoform 3 and isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_031332"
FT VAR_SEQ 745
FT /note="Missing (in isoform 2 and isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_031333"
FT CONFLICT 295
FT /note="A -> T (in Ref. 1; BAC27777)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1090 AA; 117194 MW; 15321AFC6FCDBDA9 CRC64;
MTAASTSKWG LITNVVNSIV GVSVLTMPFC FKQCGIVLGA LLLVFCSWMT HQSCMFLVKS
ASLSKRRTYA GLAFHAYGKA GKMLVETSMI GLMLGSCITF YVVIGDLGSN FFAPLLGLQV
TRTVRVFLLF AVSLFIVLPL SLQRNMMASI QSFSAMALLF YTVFMFVIVL SSLKHGLFSG
QWLRQVSYIR WEGVFRCVPI FGMSFACQSQ VLPTYDSLDE PSVKTMSSIF ASSLNVVTAF
YVMVGFFGYV SFTDATTGNV LIHFPSNPVT EMIRVGFVMS VAVGFPMMIL PCRQALNTLL
FEQQQKDGTF AAGGYMPPLR FKVLTLSVVF GTMVGGVMIP NVETILGFTG ATMGSLICFI
CPALIYKKAH KNAPSAQVVL WVGLGILVVS TLTTLSVTEE APLDLTQEAR SGHRGDAEGA
MKVEAARLSV QDPVVVVAED SQEKLKPAED KEVLEQAQIK GPVDVPGGEA PKEKQEAAQL
DRPGQGIAVP MGEAHRHEPP IPHDKVVVDE GQDQEGPEEK KPPPRLPDEG DPAGRGQGAP
PLPESEKEKQ EPERGGEGKR PGQVLAVGET EHPQKVPEAN GQPPVQPRKE DSRPGNRDPQ
PAAQARDSVE LKALAADDGR EPAQKAGGAL WKPVESAAES DAGGKAGLPV QRPEAAEQRE
KKEAEQQGGD QAGSKLEAEI KKLVAEAGRA EMLDHAVLLQ VIQEQQVQQK RLLDQQEKLL
AVIEEQHKEI RQQRQEGEED KPKPADVQPE PGVAVLRGQE EEAEHAGETL GDDPSQPLQP
VLGAPRGRPA PSQDMGQHLP GEVKVLPGRD LADLPAGGSE TEPQGAPIDL REDPKAAIKA
AGAGKELVPG DLEAVHKAAP PEVPKSPEKQ VAKAVAGQRQ DVFGEGSEER KETGKEAMAP
GADTQKEAVQ PLVGAEAKDT KSRQSGPTKA PVQTQAKFHP EPQAIFDTGQ GSHPEVRSEA
PRAVHIPPEE QHKGKGGAAI QEAKQRPDPN SGPKLAVPAG QKPENAKPNR DLKVQAGSDL
RRRRRDLASH PEQELAPKDG VIISFNSLPN VQVNDLRSAL DTQLRQAAGA ALQVVHSRQI
KQLSGDLEEA
