S38AA_RAT
ID S38AA_RAT Reviewed; 1099 AA.
AC E9PT23;
DT 11-NOV-2015, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2015, sequence version 2.
DT 03-AUG-2022, entry version 61.
DE RecName: Full=Putative sodium-coupled neutral amino acid transporter 10;
DE AltName: Full=Solute carrier family 38 member 10;
GN Name=Slc38a10;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RX PubMed=15057822; DOI=10.1038/nature02426;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2]
RP TISSUE SPECIFICITY.
RX PubMed=18418736; DOI=10.1007/s12031-008-9046-x;
RA Sundberg B.E., Waaaag E., Jacobsson J.A., Stephansson O., Rumaks J.,
RA Svirskis S., Alsioe J., Roman E., Ebendal T., Klusa V., Fredriksson R.;
RT "The evolutionary history and tissue mapping of amino acid transporters
RT belonging to solute carrier families SLC32, SLC36, and SLC38.";
RL J. Mol. Neurosci. 35:179-193(2008).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-441; SER-607 AND SER-886, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903; DOI=10.1038/ncomms1871;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
CC -!- FUNCTION: Putative sodium-dependent amino acid/proton antiporter.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Only expressed in the pituitary, adrenal gland,
CC stomach and in the upper gastrointestinal tract.
CC {ECO:0000269|PubMed:18418736}.
CC -!- SIMILARITY: Belongs to the amino acid/polyamine transporter 2 family.
CC {ECO:0000305}.
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DR EMBL; AABR07030916; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AABR07030917; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH473948; EDM06818.1; -; Genomic_DNA.
DR RefSeq; XP_001081800.3; XM_001081800.6.
DR RefSeq; XP_221195.5; XM_221195.8.
DR AlphaFoldDB; E9PT23; -.
DR SMR; E9PT23; -.
DR STRING; 10116.ENSRNOP00000006225; -.
DR iPTMnet; E9PT23; -.
DR jPOST; E9PT23; -.
DR PaxDb; E9PT23; -.
DR PeptideAtlas; E9PT23; -.
DR PRIDE; E9PT23; -.
DR GeneID; 303740; -.
DR CTD; 124565; -.
DR RGD; 1306356; Slc38a10.
DR VEuPathDB; HostDB:ENSRNOG00000004604; -.
DR eggNOG; KOG1305; Eukaryota.
DR HOGENOM; CLU_009020_6_0_1; -.
DR InParanoid; E9PT23; -.
DR OMA; ANWLVAG; -.
DR OrthoDB; 1109791at2759; -.
DR PRO; PR:E9PT23; -.
DR Proteomes; UP000002494; Chromosome 10.
DR Proteomes; UP000234681; Chromosome 10.
DR Bgee; ENSRNOG00000004604; Expressed in liver and 19 other tissues.
DR Genevisible; E9PT23; RN.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015179; F:L-amino acid transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0003333; P:amino acid transmembrane transport; IBA:GO_Central.
DR GO; GO:0060348; P:bone development; ISO:RGD.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR013057; AA_transpt_TM.
DR Pfam; PF01490; Aa_trans; 1.
PE 1: Evidence at protein level;
KW Amino-acid transport; Coiled coil; Ion transport; Membrane; Phosphoprotein;
KW Reference proteome; Sodium; Sodium transport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..1099
FT /note="Putative sodium-coupled neutral amino acid
FT transporter 10"
FT /id="PRO_0000434576"
FT TRANSMEM 9..31
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 36..58
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 84..104
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 123..143
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 153..173
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 229..249
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 323..343
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 345..365
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 378..398
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 440..679
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 720..1047
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 698..734
FT /evidence="ECO:0000255"
FT COMPBIAS 442..457
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 496..528
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 545..565
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 720..737
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 748..768
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 823..838
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 848..896
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 953..967
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1013..1041
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 441
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT MOD_RES 607
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT MOD_RES 635
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5I012"
FT MOD_RES 767
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9HBR0"
FT MOD_RES 886
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
SQ SEQUENCE 1099 AA; 118797 MW; E3695F985F3A263E CRC64;
MTAASTSKWG LVTNVVNSIV GVSVLTMPFC FKQCGIVLGA LLLVFCSWMT HQSCMFLVKS
ASLSKRRTYA GLAFHAYGKA GKMLVETSMI GLMLGSCITF YVVIGDLGSN FFAPLLGLQV
TRTFRVFLLF AVSLCIVLPL SLQRNMMASI QSFSAMALLF YTVFMFVIVL SSFKHGLFSG
QWLQRVSYIR WEGVFRCVPI FGMSFACQSQ VLPTYDSLDE PSVKTMSSIF ASSLNVVTAF
YVMVGFFGYV SFTDATTGNV LIHFPSNLVT EMIRVGFVMS VAVGFPMMIL PCRQALNTLL
FEQQQKDGTF AAGGYMPPLR FKVLTLSVVF GTMVGGVMIP NVETILGFTG ATMGSLICFI
CPALIYKKAH KNAPSAQVVL WVGLGILVVS TLTTLSVSEE APLDLTQGAR SGQRGDAEGA
MKVEAARLSV QDPVVVMAED SQEKLKPAED KEVLEQAQIK GPVDVPGGDT PKEKQEAAQL
DRPGQGIAVP MGEAHRHEPP IPHDKVVVDE GQDQEGPEEK KPPPKLPDEG DPAGRGQGAP
LLPESEKKQD PERGEEGKRP EQVLAVGEIE RPQKIPEANG QPPVQPRKED SRPGNRDLHP
VPQARVSVEL NDLVAGEGKE SAQKAGGAPW KPMESAVESN IGGKAGLAVQ RPEAAEQREK
NEAEQPGGDQ AGSKLEEAGR AEMLDHAVLL QVIKEQQVQQ KRLLDQQEKL LAVIEEQHKE
IRQQRQEGEE DKPKPADMQP EPGAAVLRGQ EEEAEHAGAP DEHAGETLED NPSQPLQPVL
GAPRGHPAPS QDKGQHPLEE VKVLAGRDLA DLPAGGSDTE PHGASSKLRE DQKGAALKVA
EAVRKLVPGD LEPVHKPDPA EVPKSPEKQL AKEVARQRQD VFGEGSQERK ETGKDAVAPG
ADTQKEAAQP LVGAEAEDSH SKSRHSEPTK VPASGPAGMG FQAQARFRQE PQVIFDKSQD
SHPEVRSEGP RGVGIPAEEQ HRGRGAAAMQ EEKQRPDPNS GPKLAVPGDQ KPENAKPNRD
LKVQAGSDLR RRRRDLASPP EQELAPKDGV IISFNSLPNV QVNDLRSALD TQLRQAAGAA
LQVVHSRQIK QLSGDLEEA
