S38AB_HUMAN
ID S38AB_HUMAN Reviewed; 406 AA.
AC Q08AI6; B4DF99; Q8N887;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 31-OCT-2006, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Putative sodium-coupled neutral amino acid transporter 11;
DE AltName: Full=Solute carrier family 38 member 11;
GN Name=SLC38A11; Synonyms=AVT2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Cerebellum, and Spleen;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Putative sodium-dependent amino acid/proton antiporter.
CC {ECO:0000305}.
CC -!- INTERACTION:
CC Q08AI6; A5PKU2: TUSC5; NbExp=3; IntAct=EBI-12819821, EBI-11988865;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q08AI6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q08AI6-2; Sequence=VSP_032529;
CC -!- SIMILARITY: Belongs to the amino acid/polyamine transporter 2 family.
CC {ECO:0000305}.
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DR EMBL; AK097141; BAC04962.1; -; mRNA.
DR EMBL; AK293998; BAG57360.1; -; mRNA.
DR EMBL; AC019197; AAY14946.1; -; Genomic_DNA.
DR EMBL; CH471058; EAX11337.1; -; Genomic_DNA.
DR EMBL; BC125157; AAI25158.1; -; mRNA.
DR CCDS; CCDS2224.1; -. [Q08AI6-2]
DR CCDS; CCDS56142.1; -. [Q08AI6-1]
DR RefSeq; NP_001186077.1; NM_001199148.1. [Q08AI6-1]
DR RefSeq; NP_775783.1; NM_173512.2. [Q08AI6-2]
DR AlphaFoldDB; Q08AI6; -.
DR SMR; Q08AI6; -.
DR BioGRID; 127360; 7.
DR IntAct; Q08AI6; 1.
DR STRING; 9606.ENSP00000386272; -.
DR TCDB; 2.A.18.6.18; the amino acid/auxin permease (aaap) family.
DR GlyGen; Q08AI6; 4 sites, 1 O-linked glycan (2 sites).
DR iPTMnet; Q08AI6; -.
DR PhosphoSitePlus; Q08AI6; -.
DR BioMuta; SLC38A11; -.
DR DMDM; 121940010; -.
DR PaxDb; Q08AI6; -.
DR PeptideAtlas; Q08AI6; -.
DR PRIDE; Q08AI6; -.
DR Antibodypedia; 47970; 9 antibodies from 7 providers.
DR DNASU; 151258; -.
DR Ensembl; ENST00000303735.8; ENSP00000306178.4; ENSG00000169507.10. [Q08AI6-2]
DR Ensembl; ENST00000409149.7; ENSP00000386272.3; ENSG00000169507.10. [Q08AI6-1]
DR Ensembl; ENST00000409662.5; ENSP00000386774.1; ENSG00000169507.10. [Q08AI6-1]
DR GeneID; 151258; -.
DR KEGG; hsa:151258; -.
DR UCSC; uc002ucu.3; human. [Q08AI6-1]
DR CTD; 151258; -.
DR GeneCards; SLC38A11; -.
DR HGNC; HGNC:26836; SLC38A11.
DR HPA; ENSG00000169507; Tissue enhanced (choroid plexus, epididymis).
DR MIM; 616526; gene.
DR neXtProt; NX_Q08AI6; -.
DR OpenTargets; ENSG00000169507; -.
DR PharmGKB; PA162403771; -.
DR VEuPathDB; HostDB:ENSG00000169507; -.
DR eggNOG; KOG1305; Eukaryota.
DR GeneTree; ENSGT00940000157782; -.
DR HOGENOM; CLU_009020_4_2_1; -.
DR InParanoid; Q08AI6; -.
DR OMA; CHHNTSF; -.
DR OrthoDB; 1109791at2759; -.
DR PhylomeDB; Q08AI6; -.
DR TreeFam; TF328787; -.
DR PathwayCommons; Q08AI6; -.
DR SignaLink; Q08AI6; -.
DR BioGRID-ORCS; 151258; 14 hits in 1060 CRISPR screens.
DR ChiTaRS; SLC38A11; human.
DR GenomeRNAi; 151258; -.
DR Pharos; Q08AI6; Tdark.
DR PRO; PR:Q08AI6; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q08AI6; protein.
DR Bgee; ENSG00000169507; Expressed in corpus epididymis and 122 other tissues.
DR ExpressionAtlas; Q08AI6; baseline and differential.
DR Genevisible; Q08AI6; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015179; F:L-amino acid transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0003333; P:amino acid transmembrane transport; IBA:GO_Central.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR013057; AA_transpt_TM.
DR Pfam; PF01490; Aa_trans; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Amino-acid transport; Glycoprotein; Ion transport;
KW Membrane; Reference proteome; Sodium; Sodium transport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..406
FT /note="Putative sodium-coupled neutral amino acid
FT transporter 11"
FT /id="PRO_0000326059"
FT TOPO_DOM 1..7
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 8..28
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 48..68
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 93..113
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 121..141
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 156..176
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 202..222
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 241..263
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 279..299
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 301..321
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 340..360
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 44
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 275
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 66..87
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_032529"
FT VARIANT 194
FT /note="A -> T (in dbSNP:rs4564790)"
FT /id="VAR_039981"
SQ SEQUENCE 406 AA; 44825 MW; 1053D3DAAEDC8296 CRC64;
MKQAGFPLGI LLLFWVSYVT DFSLVLLIKG GALSGTDTYQ SLVNKTFGFP GYLLLSVLQF
LYPFIAMISY NIIAGDTLSK VFQRIPGVDP ENVFIGRHFI IGLSTVTFTL PLSLYRNIAK
LGKVSLISTG LTTLILGIVM ARAISLGPHI PKTEDAWVFA KPNAIQAVGV MSFAFICHHN
SFLVYSSLEE PTVAKWSRLI HMSIVISVFI CIFFATCGYL TFTGFTQGDL FENYCRNDDL
VTFGRFCYGV TVILTYPMEC FVTREVIANV FFGGNLSSVF HIVVTVMVIT VATLVSLLID
CLGIVLELNG VLCATPLIFI IPSACYLKLS EEPRTHSDKI MSCVMLPIGA VVMVFGFVMA
ITNTQDCTHG QEMFYCFPDN FSLTNTSESH VQQTTQLSTL NISIFQ
