S38AB_MOUSE
ID S38AB_MOUSE Reviewed; 453 AA.
AC Q3USY0; A2ASI0; A2ASI1;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 18-MAR-2008, sequence version 2.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Putative sodium-coupled neutral amino acid transporter 11;
DE AltName: Full=Solute carrier family 38 member 11;
GN Name=Slc38a11;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Corpora quadrigemina;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- FUNCTION: Putative sodium-dependent amino acid/proton antiporter.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q3USY0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q3USY0-2; Sequence=VSP_032530;
CC Name=3;
CC IsoId=Q3USY0-3; Sequence=VSP_032531;
CC -!- SIMILARITY: Belongs to the amino acid/polyamine transporter 2 family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAE24200.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=CAM23396.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAM23397.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AK139966; BAE24200.1; ALT_FRAME; mRNA.
DR EMBL; AL928621; CAM23396.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL929132; CAM23396.1; JOINED; Genomic_DNA.
DR EMBL; AL928621; CAM23397.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL929132; CAM23397.1; JOINED; Genomic_DNA.
DR CCDS; CCDS38129.1; -. [Q3USY0-1]
DR RefSeq; NP_796048.2; NM_177074.2. [Q3USY0-1]
DR AlphaFoldDB; Q3USY0; -.
DR SMR; Q3USY0; -.
DR STRING; 10090.ENSMUSP00000108039; -.
DR GlyGen; Q3USY0; 2 sites.
DR iPTMnet; Q3USY0; -.
DR PhosphoSitePlus; Q3USY0; -.
DR PaxDb; Q3USY0; -.
DR PRIDE; Q3USY0; -.
DR ProteomicsDB; 260780; -. [Q3USY0-1]
DR ProteomicsDB; 260781; -. [Q3USY0-2]
DR ProteomicsDB; 260782; -. [Q3USY0-3]
DR Antibodypedia; 47970; 9 antibodies from 7 providers.
DR DNASU; 320106; -.
DR Ensembl; ENSMUST00000112420; ENSMUSP00000108039; ENSMUSG00000061171. [Q3USY0-1]
DR GeneID; 320106; -.
DR KEGG; mmu:320106; -.
DR UCSC; uc008jwj.1; mouse. [Q3USY0-1]
DR CTD; 151258; -.
DR MGI; MGI:2443383; Slc38a11.
DR VEuPathDB; HostDB:ENSMUSG00000061171; -.
DR eggNOG; KOG1305; Eukaryota.
DR GeneTree; ENSGT00940000157782; -.
DR InParanoid; Q3USY0; -.
DR OMA; CHHNTSF; -.
DR OrthoDB; 1109791at2759; -.
DR PhylomeDB; Q3USY0; -.
DR TreeFam; TF328787; -.
DR BioGRID-ORCS; 320106; 3 hits in 74 CRISPR screens.
DR ChiTaRS; Slc38a11; mouse.
DR PRO; PR:Q3USY0; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q3USY0; protein.
DR Bgee; ENSMUSG00000061171; Expressed in adrenal gland and 53 other tissues.
DR ExpressionAtlas; Q3USY0; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015179; F:L-amino acid transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0003333; P:amino acid transmembrane transport; IBA:GO_Central.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR013057; AA_transpt_TM.
DR Pfam; PF01490; Aa_trans; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Amino-acid transport; Glycoprotein; Ion transport;
KW Membrane; Reference proteome; Sodium; Sodium transport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..453
FT /note="Putative sodium-coupled neutral amino acid
FT transporter 11"
FT /id="PRO_0000326061"
FT TRANSMEM 39..59
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 66..86
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 106..126
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 150..170
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 179..199
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 222..242
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 262..282
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 299..319
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 337..357
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 359..379
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 398..418
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 438
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 443
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 54..78
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_032530"
FT VAR_SEQ 124..145
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_032531"
SQ SEQUENCE 453 AA; 49615 MW; 77F6BAE153B7BAAF CRC64;
MSYQQPQLSG PLQRETDSSD RESLISGHEH GGKSSQSAAV FNVVNSVIGS GIIGLPYSMK
QAGFPLGILL LFLVSYITDF SLVLLIKGGA LSGTDSYQSL VNKTFGFPGY LLLSTLQFMY
PFIAMISYNI ITGDTLSKVF QRLPGVDPGG WFISRHFIIV VSTVTCTLPL SLYRDIAKLG
KISFISTILT TVILGIVMTR AISLGPNIPK TDNAWVFAKP NAIQAIGVMS FAFICHHNCF
LVYGSLEEPT VAKWRRIIHT SILVSVFICV LFATCGYFTF TGFTQGDLFE NYCRSDDLVT
FGRFCYGITV ILTYPIECFV TREVIANVFF GGTLSSVFHT VLAVLIVTAA TLVSLMIECL
GIVLELNGVL CAAPLIFIIP SACYLKLSEE PRTHSDKIMA CVMFPVGAVV MVVGFVMAIT
NPQDCTHGQE MFYCFPENVS FTNTSWSHLQ LTT
