ID   S39A1_BOVIN             Reviewed;         324 AA.
AC   Q3SYU3;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Zinc transporter ZIP1;
DE   AltName: Full=Solute carrier family 39 member 1;
DE   AltName: Full=Zrt- and Irt-like protein 1;
DE            Short=ZIP-1;
GN   Name=SLC39A1; Synonyms=ZIP1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mediates zinc uptake. May function as a major endogenous zinc
CC       uptake transporter in many cells of the body (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC       {ECO:0000305}.
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DR   EMBL; BC103384; AAI03385.1; -; mRNA.
DR   RefSeq; NP_001030458.1; NM_001035381.2.
DR   AlphaFoldDB; Q3SYU3; -.
DR   SMR; Q3SYU3; -.
DR   STRING; 9913.ENSBTAP00000033917; -.
DR   PaxDb; Q3SYU3; -.
DR   PRIDE; Q3SYU3; -.
DR   Ensembl; ENSBTAT00000034015; ENSBTAP00000033917; ENSBTAG00000011284.
DR   GeneID; 530352; -.
DR   KEGG; bta:530352; -.
DR   CTD; 27173; -.
DR   VEuPathDB; HostDB:ENSBTAG00000011284; -.
DR   VGNC; VGNC:34857; SLC39A1.
DR   eggNOG; KOG1558; Eukaryota.
DR   GeneTree; ENSGT00940000157062; -.
DR   HOGENOM; CLU_040462_1_0_1; -.
DR   InParanoid; Q3SYU3; -.
DR   OMA; HSSLHTD; -.
DR   OrthoDB; 981397at2759; -.
DR   TreeFam; TF317098; -.
DR   Reactome; R-BTA-442380; Zinc influx into cells by the SLC39 gene family.
DR   Proteomes; UP000009136; Chromosome 3.
DR   Bgee; ENSBTAG00000011284; Expressed in placenta and 105 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0005385; F:zinc ion transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0048701; P:embryonic cranial skeleton morphogenesis; IEA:Ensembl.
DR   GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl.
DR   GO; GO:0060173; P:limb development; IEA:Ensembl.
DR   GO; GO:0071577; P:zinc ion transmembrane transport; ISS:UniProtKB.
DR   InterPro; IPR003689; ZIP.
DR   Pfam; PF02535; Zip; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Ion transport; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport; Zinc; Zinc transport.
FT   CHAIN           1..324
FT                   /note="Zinc transporter ZIP1"
FT                   /id="PRO_0000283726"
FT   TOPO_DOM        1..30
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        31..51
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        52..68
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        69..89
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        90..104
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        105..125
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        126..179
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        180..200
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        201..206
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        207..227
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        228..237
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        238..258
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        259..272
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        273..293
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        294..303
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        304..324
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   324 AA;  34205 MW;  3B2007EC09F8DD73 CRC64;
     MGPWGEPELL VWRPEAAASE APVPMGLEVK LGALVLLLVL TLICSLVPVC VLRRPGANPE
     ASASRQKALS LVSCFAGGVF LATCLLDLLP DYLGAIDEAL AALHVTLQFP LQEFILAMGF
     FLVLVMEQIT LAYKEQSGPP PREETRALLG TVNGGPQHWH DGLGVPQAGG ASSAPSALRA
     CVLVFSLALH SVFEGLAVGL QRDQARAMEL CLALLLHKGI LAVSLSLRLL QSHLRAQVVA
     GCGILFSCMT PLGIGLGTAL AESAGPLHQL AQSVLEGMAA GTFLYITFLE ILPQELATSE
     QRILKVILLL AGFALLTGLL FIQI