S39A1_DANRE
ID S39A1_DANRE Reviewed; 302 AA.
AC P59889; Q4V9K6;
DT 26-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT 26-SEP-2003, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Zinc transporter ZIP1;
DE AltName: Full=DrZIP1;
DE AltName: Full=Solute carrier family 39 member 1;
DE AltName: Full=Zrt- and Irt-like protein 1;
DE Short=ZIP-1;
GN Name=slc39a1; Synonyms=zip1; ORFNames=sb:cb629, zgc:111852;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, AND TISSUE
RP SPECIFICITY.
RC TISSUE=Gill;
RX PubMed=15683366; DOI=10.1042/bj20041807;
RA Qiu A., Shayeghi M., Hogstrand C.;
RT "Molecular cloning and functional characterization of a high-affinity zinc
RT importer (DrZIP1) from zebrafish (Danio rerio).";
RL Biochem. J. 388:745-754(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=AB; TISSUE=Intestine;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Mediates zinc uptake. {ECO:0000269|PubMed:15683366}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15683366};
CC Multi-pass membrane protein {ECO:0000269|PubMed:15683366}.
CC -!- TISSUE SPECIFICITY: Ubiquitous. Highest levels in ovary, high levels in
CC heart, eye, kidney and brain, moderate levels in intestine and low
CC levels in gill and skin. {ECO:0000269|PubMed:15683366}.
CC -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC {ECO:0000305}.
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DR EMBL; AY314992; AAP83180.1; -; mRNA.
DR EMBL; BC096852; AAH96852.1; -; mRNA.
DR RefSeq; NP_997748.2; NM_212583.2.
DR AlphaFoldDB; P59889; -.
DR SMR; P59889; -.
DR STRING; 7955.ENSDARP00000062256; -.
DR TCDB; 2.A.5.3.5; the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.
DR PaxDb; P59889; -.
DR Ensembl; ENSDART00000062257; ENSDARP00000062256; ENSDARG00000058257.
DR Ensembl; ENSDART00000191509; ENSDARP00000153420; ENSDARG00000112079.
DR GeneID; 321324; -.
DR KEGG; dre:321324; -.
DR CTD; 27173; -.
DR ZFIN; ZDB-GENE-030131-9917; slc39a1.
DR eggNOG; KOG1558; Eukaryota.
DR GeneTree; ENSGT00940000164669; -.
DR HOGENOM; CLU_040462_1_0_1; -.
DR InParanoid; P59889; -.
DR OMA; FGLLAKW; -.
DR OrthoDB; 981397at2759; -.
DR PhylomeDB; P59889; -.
DR TreeFam; TF317098; -.
DR Reactome; R-DRE-442380; Zinc influx into cells by the SLC39 gene family.
DR PRO; PR:P59889; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 7.
DR Bgee; ENSDARG00000058257; Expressed in gastrula and 19 other tissues.
DR ExpressionAtlas; P59889; baseline.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IDA:ZFIN.
DR GO; GO:0008270; F:zinc ion binding; IDA:ZFIN.
DR GO; GO:0005385; F:zinc ion transmembrane transporter activity; ISS:ZFIN.
DR GO; GO:0071577; P:zinc ion transmembrane transport; ISS:UniProtKB.
DR GO; GO:0006829; P:zinc ion transport; IDA:ZFIN.
DR InterPro; IPR003689; ZIP.
DR Pfam; PF02535; Zip; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Ion transport; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport; Zinc; Zinc transport.
FT CHAIN 1..302
FT /note="Zinc transporter ZIP1"
FT /id="PRO_0000068765"
FT TOPO_DOM 1..6
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 7..27
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 28..44
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 45..65
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 66..86
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 108..158
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 159..179
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 180..185
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 186..206
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 207..219
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 220..240
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 241..247
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 248..268
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 269..281
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 282..302
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 8
FT /note="K -> R (in Ref. 2; AAH96852)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 302 AA; 32822 MW; 96B8863752C5CF70 CRC64;
MDYLLQVKVG ALVGLLLLTL FFGFIPARMK WFHVTGGTEL HKAVLSFVSC FAGGVFLSAC
LLDIIPDYLS DIHGELQKRD LDDGFPLPEF IMACGFFTVL ILEKMVLSCT EGHRNEETAP
LLAPAAPNGH AHGHPSVNDL EGSGHHVHVD FHAHSSFRSF MLFLSLSLHS VFEGLAIGLQ
TTNAKVLEIC IAILVHKSII VFSLSVKLVQ SAVKPLWVVL YVTVFAIMSP LGIGIGIVVI
ETERQAGGLI QAVLEGLAAG TFIYITFLEI LPHELNSSER PLLKVLFLLC GFSIMAALCF
LG
