S39A1_MOUSE
ID S39A1_MOUSE Reviewed; 324 AA.
AC Q9QZ03; A2RTD4; Q99K44;
DT 26-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 3.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Zinc transporter ZIP1;
DE AltName: Full=Solute carrier family 39 member 1;
DE AltName: Full=Zinc-iron-regulated transporter-like;
DE AltName: Full=Zrt- and Irt-like protein 1;
DE Short=ZIP-1;
DE Short=mZIP1;
GN Name=Slc39a1; Synonyms=Zip1, Zirtl;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP STAGE.
RX PubMed=10610721; DOI=10.1006/geno.1999.5993;
RA Lioumi M., Ferguson C.A., Sharpe P.T., Freeman T., Marenholz I.,
RA Mischke D., Heizmann C., Ragoussis J.;
RT "Isolation and characterization of human and mouse ZIRTL, a member of the
RT IRT1 family of transporters, mapping within the epidermal differentiation
RT complex.";
RL Genomics 62:272-280(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Mediates zinc uptake. May function as a major endogenous zinc
CC uptake transporter in many cells of the body (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Ubiquitous. Highest levels seen in kidney, salivary
CC gland and placenta. {ECO:0000269|PubMed:10610721}.
CC -!- DEVELOPMENTAL STAGE: Found to be developmentally regulated in the skin
CC where it is expressed in the epidermal layer, excluding the dermis, at
CC embryonic day 17.5 dpc but not in 10.5 dpc and 15.5 dpc. In the small
CC intestine found toward the base of the intestinal villi from 17.5 dpc.
CC In the pancreas, expression was detected from 17.5 dpc and no
CC expression was found in the liver. Also expressed in osteoblasts of
CC developing bone from 15.5 dpc. {ECO:0000269|PubMed:10610721}.
CC -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB59982.1; Type=Frameshift; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AJ243651; CAB59982.1; ALT_FRAME; Genomic_DNA.
DR EMBL; CH466547; EDL15152.1; -; Genomic_DNA.
DR EMBL; BC005474; AAH05474.1; -; mRNA.
DR EMBL; BC132461; AAI32462.1; -; mRNA.
DR EMBL; BC138459; AAI38460.1; -; mRNA.
DR EMBL; BC147738; AAI47739.1; -; mRNA.
DR EMBL; BC147744; AAI47745.1; -; mRNA.
DR CCDS; CCDS17525.1; -.
DR RefSeq; NP_038929.2; NM_013901.2.
DR RefSeq; XP_006501623.1; XM_006501560.3.
DR AlphaFoldDB; Q9QZ03; -.
DR SMR; Q9QZ03; -.
DR BioGRID; 205964; 3.
DR STRING; 10090.ENSMUSP00000076012; -.
DR iPTMnet; Q9QZ03; -.
DR PhosphoSitePlus; Q9QZ03; -.
DR SwissPalm; Q9QZ03; -.
DR MaxQB; Q9QZ03; -.
DR PaxDb; Q9QZ03; -.
DR PRIDE; Q9QZ03; -.
DR ProteomicsDB; 256572; -.
DR Antibodypedia; 20389; 109 antibodies from 27 providers.
DR DNASU; 30791; -.
DR Ensembl; ENSMUST00000015467; ENSMUSP00000076012; ENSMUSG00000052310.
DR GeneID; 30791; -.
DR KEGG; mmu:30791; -.
DR UCSC; uc012csu.1; mouse.
DR CTD; 27173; -.
DR MGI; MGI:1353474; Slc39a1.
DR VEuPathDB; HostDB:ENSMUSG00000052310; -.
DR eggNOG; KOG1558; Eukaryota.
DR GeneTree; ENSGT00940000157062; -.
DR HOGENOM; CLU_040462_1_0_1; -.
DR InParanoid; Q9QZ03; -.
DR OMA; FGFAPLC; -.
DR OrthoDB; 981397at2759; -.
DR PhylomeDB; Q9QZ03; -.
DR TreeFam; TF317098; -.
DR Reactome; R-MMU-442380; Zinc influx into cells by the SLC39 gene family.
DR BioGRID-ORCS; 30791; 5 hits in 71 CRISPR screens.
DR ChiTaRS; Slc39a1; mouse.
DR PRO; PR:Q9QZ03; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q9QZ03; protein.
DR Bgee; ENSMUSG00000052310; Expressed in prostate gland and 149 other tissues.
DR Genevisible; Q9QZ03; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0005102; F:signaling receptor binding; ISO:MGI.
DR GO; GO:0005385; F:zinc ion transmembrane transporter activity; IDA:MGI.
DR GO; GO:0048701; P:embryonic cranial skeleton morphogenesis; IMP:MGI.
DR GO; GO:0001701; P:in utero embryonic development; IMP:MGI.
DR GO; GO:0060173; P:limb development; IMP:MGI.
DR GO; GO:0071577; P:zinc ion transmembrane transport; ISO:MGI.
DR GO; GO:0006829; P:zinc ion transport; IDA:MGI.
DR InterPro; IPR003689; ZIP.
DR Pfam; PF02535; Zip; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Ion transport; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport; Zinc; Zinc transport.
FT CHAIN 1..324
FT /note="Zinc transporter ZIP1"
FT /id="PRO_0000068764"
FT TOPO_DOM 1..30
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 31..51
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 52..68
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 69..89
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 90..104
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 105..125
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 126..179
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 180..200
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 201..206
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 207..227
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 228..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..272
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..293
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 294..303
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 304..324
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 19
FT /note="S -> L (in Ref. 1; CAB59982)"
FT /evidence="ECO:0000305"
FT CONFLICT 29
FT /note="V -> G (in Ref. 1; CAB59982)"
FT /evidence="ECO:0000305"
FT CONFLICT 36
FT /note="Missing (in Ref. 1; CAB59982)"
FT /evidence="ECO:0000305"
FT CONFLICT 44
FT /note="C -> G (in Ref. 1; CAB59982)"
FT /evidence="ECO:0000305"
FT CONFLICT 137
FT /note="T -> S (in Ref. 1; CAB59982 and 3; AAH05474)"
FT /evidence="ECO:0000305"
FT CONFLICT 142..143
FT /note="PE -> SK (in Ref. 1; CAB59982)"
FT /evidence="ECO:0000305"
FT CONFLICT 177
FT /note="A -> T (in Ref. 1; CAB59982)"
FT /evidence="ECO:0000305"
FT CONFLICT 183
FT /note="L -> P (in Ref. 1; CAB59982)"
FT /evidence="ECO:0000305"
FT CONFLICT 200..203
FT /note="LQRD -> FQPN (in Ref. 1; CAB59982)"
FT /evidence="ECO:0000305"
FT CONFLICT 209..210
FT /note="EL -> DC (in Ref. 1; CAB59982)"
FT /evidence="ECO:0000305"
FT CONFLICT 279
FT /note="A -> E (in Ref. 1; CAB59982)"
FT /evidence="ECO:0000305"
FT CONFLICT 288
FT /note="F -> Y (in Ref. 1; CAB59982)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 324 AA; 34293 MW; E7962CDB4726D6B3 CRC64;
MGPWGEPELL VWRPEAVASE PSVPVGLEVK LGALVLLLLL TLICSLVPVC VLRRSGANHE
ASASGQKALS LVSCFAGGVF LATCLLDLLP DYLAAIDEAL EALHVTLQFP LQEFILAMGF
FLVLVMEQIT LAYKEQTSPP HPEETRALLG TVNGGPQHWH DGPGIPQAGG TPAAPSALRA
CVLVFSLALH SVFEGLAVGL QRDRARAMEL CLALLLHKGI LAVSLSLRLL QSHLRVQVVA
GCGILFSCMT PLGIGLGAAL AESAGPLHQL AQSVLEGMAA GTFLYITFLE ILPQELATSE
QRILKVILLL AGFALLTGLL FVQI
