ID   S39A1_TAKRU             Reviewed;         302 AA.
AC   Q6QQT1;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Zinc transporter ZIP1;
DE   AltName: Full=Solute carrier family 39 member 1;
DE   AltName: Full=Zrt- and Irt-like protein 1;
DE            Short=ZIP-1;
GN   Name=slc39a1; Synonyms=zip1;
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:AAS21267.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Gill {ECO:0000269|PubMed:15683366};
RX   PubMed=15683366; DOI=10.1042/bj20041807;
RA   Qiu A., Shayeghi M., Hogstrand C.;
RT   "Molecular cloning and functional characterization of a high-affinity zinc
RT   importer (DrZIP1) from zebrafish (Danio rerio).";
RL   Biochem. J. 388:745-754(2005).
CC   -!- FUNCTION: Mediates zinc uptake. {ECO:0000250|UniProtKB:P59889}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Highest levels in ovary, lower levels in intestine
CC       and gill, barely detected in kidney. {ECO:0000269|PubMed:15683366}.
CC   -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC       {ECO:0000255}.
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DR   EMBL; AY529485; AAS21267.1; -; mRNA.
DR   RefSeq; NP_001027873.1; NM_001032701.1.
DR   AlphaFoldDB; Q6QQT1; -.
DR   SMR; Q6QQT1; -.
DR   STRING; 31033.ENSTRUP00000043240; -.
DR   GeneID; 446094; -.
DR   KEGG; tru:446094; -.
DR   CTD; 27173; -.
DR   eggNOG; KOG1558; Eukaryota.
DR   InParanoid; Q6QQT1; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0046873; F:metal ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0071577; P:zinc ion transmembrane transport; ISS:UniProtKB.
DR   InterPro; IPR003689; ZIP.
DR   Pfam; PF02535; Zip; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Ion transport; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport; Zinc; Zinc transport.
FT   CHAIN           1..302
FT                   /note="Zinc transporter ZIP1"
FT                   /id="PRO_0000068766"
FT   TOPO_DOM        1..6
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        7..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        28..44
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        45..65
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        66..80
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        81..101
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        102..158
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        159..179
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        180..185
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        186..206
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        207..216
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        217..237
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        238..251
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        252..272
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        273..281
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        282..302
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          123..145
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   302 AA;  33038 MW;  F8E1B5DC06C64ADB CRC64;
     MEYLLQVKIA ALVGLLFLTL IFGFIPARVK WFRDTDGTET HRTVLSLISC FAGGVFLSAC
     FLDIIPDYLS DINTELHARQ LETSFPLPEF IMAAGFFTVL ILERIVLNCK EMRATHEERT
     TLIPERKSGH GHGHGDGPDP ESSGHHVHVD FQAHSPFRSF MLFLSLSLHS IFEGLAIGLQ
     TTDPKVVEIC IAILVHKSII VFSLAVKLVQ SAIPPLWVAA YIGVFALMSP VGIAIGISVM
     EAQLAAGPLI QAILEGFAAG TFVYITFLEI LPHELNSPGK QLLKVLFLLL GFSIMAALSF
     LG