S39A2_HUMAN
ID S39A2_HUMAN Reviewed; 309 AA.
AC Q9NP94; B2RC76; G3V5X2; Q4QQJ1; Q4V9S4; Q96JT6; Q9UD20;
DT 26-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Zinc transporter ZIP2;
DE AltName: Full=6A1;
DE AltName: Full=Eti-1;
DE AltName: Full=Solute carrier family 39 member 2;
DE AltName: Full=Zrt- and Irt-like protein 2;
DE Short=ZIP-2;
DE Short=hZIP2;
GN Name=SLC39A2; Synonyms=ZIP2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANT LEU-115.
RC TISSUE=Uterine ectocervix;
RX PubMed=7751801; DOI=10.5357/koubyou.62.78;
RA Yamaguchi S.;
RT "Subtraction cloning of growth arrest inducible genes in normal human
RT epithelial cells.";
RL Kokubyo Gakkai Zasshi 62:78-93(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), CHARACTERIZATION, AND VARIANT
RP LEU-115.
RC TISSUE=Prostate;
RX PubMed=10681536; DOI=10.1074/jbc.275.8.5560;
RA Gaither L.A., Eide D.J.;
RT "Functional expression of the human hZIP2 zinc transporter.";
RL J. Biol. Chem. 275:5560-5564(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Prostate;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12508121; DOI=10.1038/nature01348;
RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA Waterston R., Hood L., Weissenbach J.;
RT "The DNA sequence and analysis of human chromosome 14.";
RL Nature 421:601-607(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT LEU-115.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 183-242 (ISOFORM 1).
RC TISSUE=Prostate;
RA Nong G., Buszko M.L., Sweeney C.A., Furman J., Rice L.P.;
RT "Expression of zinc transporters in human prostate.";
RL Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Mediates zinc uptake. Zinc uptake may be mediated by a
CC Zn(2+)-HCO(3)(-) symport mechanism and can function in the presence of
CC albumin. May also transport other divalent cations. May be important in
CC contact inhibition of normal epithelial cells and loss of its
CC expression may play a role in tumorigenesis.
CC -!- INTERACTION:
CC Q9NP94; P29972: AQP1; NbExp=3; IntAct=EBI-12898013, EBI-745213;
CC Q9NP94; Q13520: AQP6; NbExp=3; IntAct=EBI-12898013, EBI-13059134;
CC Q9NP94; Q3SXY8: ARL13B; NbExp=3; IntAct=EBI-12898013, EBI-11343438;
CC Q9NP94; Q92843: BCL2L2; NbExp=3; IntAct=EBI-12898013, EBI-707714;
CC Q9NP94; Q8WVV5: BTN2A2; NbExp=3; IntAct=EBI-12898013, EBI-8648738;
CC Q9NP94; Q8WVX3-2: C4orf3; NbExp=3; IntAct=EBI-12898013, EBI-12003442;
CC Q9NP94; P11912: CD79A; NbExp=3; IntAct=EBI-12898013, EBI-7797864;
CC Q9NP94; P34972: CNR2; NbExp=3; IntAct=EBI-12898013, EBI-2835940;
CC Q9NP94; P29400-2: COL4A5; NbExp=3; IntAct=EBI-12898013, EBI-12211159;
CC Q9NP94; P21964: COMT; NbExp=3; IntAct=EBI-12898013, EBI-372265;
CC Q9NP94; Q96BA8: CREB3L1; NbExp=3; IntAct=EBI-12898013, EBI-6942903;
CC Q9NP94; P25025: CXCR2; NbExp=3; IntAct=EBI-12898013, EBI-2835281;
CC Q9NP94; P49447: CYB561; NbExp=3; IntAct=EBI-12898013, EBI-8646596;
CC Q9NP94; Q08426: EHHADH; NbExp=3; IntAct=EBI-12898013, EBI-2339219;
CC Q9NP94; Q9BV81: EMC6; NbExp=3; IntAct=EBI-12898013, EBI-2820492;
CC Q9NP94; Q92520: FAM3C; NbExp=3; IntAct=EBI-12898013, EBI-2876774;
CC Q9NP94; Q14802-3: FXYD3; NbExp=3; IntAct=EBI-12898013, EBI-12175685;
CC Q9NP94; Q9H0Q3: FXYD6; NbExp=3; IntAct=EBI-12898013, EBI-713304;
CC Q9NP94; O75084: FZD7; NbExp=3; IntAct=EBI-12898013, EBI-746917;
CC Q9NP94; P48165: GJA8; NbExp=3; IntAct=EBI-12898013, EBI-17458373;
CC Q9NP94; Q8TDT2: GPR152; NbExp=3; IntAct=EBI-12898013, EBI-13345167;
CC Q9NP94; O15529: GPR42; NbExp=3; IntAct=EBI-12898013, EBI-18076404;
CC Q9NP94; O95867: LY6G6C; NbExp=3; IntAct=EBI-12898013, EBI-9088345;
CC Q9NP94; Q6ZSS7: MFSD6; NbExp=3; IntAct=EBI-12898013, EBI-2858252;
CC Q9NP94; Q5J8X5: MS4A13; NbExp=3; IntAct=EBI-12898013, EBI-12070086;
CC Q9NP94; Q8IXM6: NRM; NbExp=3; IntAct=EBI-12898013, EBI-10262547;
CC Q9NP94; P26678: PLN; NbExp=3; IntAct=EBI-12898013, EBI-692836;
CC Q9NP94; P54315: PNLIPRP1; NbExp=3; IntAct=EBI-12898013, EBI-8652812;
CC Q9NP94; Q96IW7: SEC22A; NbExp=3; IntAct=EBI-12898013, EBI-8652744;
CC Q9NP94; P54219-3: SLC18A1; NbExp=3; IntAct=EBI-12898013, EBI-17595455;
CC Q9NP94; Q9BRI3: SLC30A2; NbExp=3; IntAct=EBI-12898013, EBI-8644112;
CC Q9NP94; Q8IWU4: SLC30A8; NbExp=3; IntAct=EBI-12898013, EBI-10262251;
CC Q9NP94; Q9NUM3: SLC39A9; NbExp=3; IntAct=EBI-12898013, EBI-2823239;
CC Q9NP94; Q6ZP29-3: SLC66A1; NbExp=3; IntAct=EBI-12898013, EBI-12889586;
CC Q9NP94; P30825: SLC7A1; NbExp=3; IntAct=EBI-12898013, EBI-4289564;
CC Q9NP94; Q8WWF3: SSMEM1; NbExp=3; IntAct=EBI-12898013, EBI-17280858;
CC Q9NP94; Q96JF0-2: ST6GAL2; NbExp=3; IntAct=EBI-12898013, EBI-12908338;
CC Q9NP94; P02808: STATH; NbExp=3; IntAct=EBI-12898013, EBI-738687;
CC Q9NP94; Q6UX40: TMEM107; NbExp=3; IntAct=EBI-12898013, EBI-12845616;
CC Q9NP94; Q9NUH8: TMEM14B; NbExp=3; IntAct=EBI-12898013, EBI-8638294;
CC Q9NP94; Q8NBD8: TMEM229B; NbExp=3; IntAct=EBI-12898013, EBI-12195227;
CC Q9NP94; Q96Q45-2: TMEM237; NbExp=3; IntAct=EBI-12898013, EBI-10982110;
CC Q9NP94; Q969K7: TMEM54; NbExp=3; IntAct=EBI-12898013, EBI-3922833;
CC Q9NP94; Q9H2L4: TMEM60; NbExp=3; IntAct=EBI-12898013, EBI-2852148;
CC Q9NP94; Q8N2M4: TMEM86A; NbExp=3; IntAct=EBI-12898013, EBI-12015604;
CC Q9NP94; P34981: TRHR; NbExp=3; IntAct=EBI-12898013, EBI-18055230;
CC Q9NP94; Q5BVD1: TTMP; NbExp=3; IntAct=EBI-12898013, EBI-10243654;
CC Q9NP94; Q9Y385: UBE2J1; NbExp=3; IntAct=EBI-12898013, EBI-988826;
CC Q9NP94; O75841: UPK1B; NbExp=3; IntAct=EBI-12898013, EBI-12237619;
CC Q9NP94; O95183: VAMP5; NbExp=3; IntAct=EBI-12898013, EBI-10191195;
CC Q9NP94; Q96EC8: YIPF6; NbExp=3; IntAct=EBI-12898013, EBI-751210;
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9NP94-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9NP94-2; Sequence=VSP_046889, VSP_046890;
CC -!- TISSUE SPECIFICITY: Expressed only in prostate and uterine epithelial
CC cells.
CC -!- INDUCTION: Shows a dramatic induction in normal epithelial cells
CC contact inhibition.
CC -!- MISCELLANEOUS: Zinc uptake is inhibited at pH levels below 7.0 and is
CC stimulated at higher pH and is significantly inhibited by Cu(2+),
CC Co(2+) and Mn(2+) ions. Not inhibited by Fe(2+).
CC -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC {ECO:0000305}.
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DR EMBL; D83039; BAA94313.1; -; mRNA.
DR EMBL; AF186081; AAF35832.1; -; mRNA.
DR EMBL; AK314974; BAG37473.1; -; mRNA.
DR EMBL; AL161668; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL355922; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC096723; AAH96723.1; -; mRNA.
DR EMBL; BC098254; AAH98254.1; -; mRNA.
DR EMBL; BC110057; AAI10058.1; -; mRNA.
DR EMBL; AY029483; AAK40258.1; -; mRNA.
DR CCDS; CCDS58303.1; -. [Q9NP94-2]
DR CCDS; CCDS9563.1; -. [Q9NP94-1]
DR RefSeq; NP_001243517.1; NM_001256588.1. [Q9NP94-2]
DR RefSeq; NP_055394.2; NM_014579.3. [Q9NP94-1]
DR AlphaFoldDB; Q9NP94; -.
DR SMR; Q9NP94; -.
DR BioGRID; 119012; 48.
DR IntAct; Q9NP94; 51.
DR STRING; 9606.ENSP00000298681; -.
DR DrugBank; DB14533; Zinc chloride.
DR DrugBank; DB14548; Zinc sulfate, unspecified form.
DR TCDB; 2.A.5.3.1; the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.
DR BioMuta; SLC39A2; -.
DR DMDM; 296452889; -.
DR PaxDb; Q9NP94; -.
DR PeptideAtlas; Q9NP94; -.
DR PRIDE; Q9NP94; -.
DR Antibodypedia; 22081; 92 antibodies from 27 providers.
DR DNASU; 29986; -.
DR Ensembl; ENST00000298681.5; ENSP00000298681.4; ENSG00000165794.10. [Q9NP94-1]
DR Ensembl; ENST00000554422.5; ENSP00000452568.1; ENSG00000165794.10. [Q9NP94-2]
DR GeneID; 29986; -.
DR KEGG; hsa:29986; -.
DR MANE-Select; ENST00000298681.5; ENSP00000298681.4; NM_014579.4; NP_055394.2.
DR UCSC; uc001vyr.4; human. [Q9NP94-1]
DR CTD; 29986; -.
DR DisGeNET; 29986; -.
DR GeneCards; SLC39A2; -.
DR HGNC; HGNC:17127; SLC39A2.
DR HPA; ENSG00000165794; Group enriched (esophagus, prostate, seminal vesicle, skin, vagina).
DR MIM; 612166; gene.
DR neXtProt; NX_Q9NP94; -.
DR OpenTargets; ENSG00000165794; -.
DR PharmGKB; PA38202; -.
DR VEuPathDB; HostDB:ENSG00000165794; -.
DR eggNOG; KOG1558; Eukaryota.
DR GeneTree; ENSGT00940000160962; -.
DR HOGENOM; CLU_2512017_0_0_1; -.
DR InParanoid; Q9NP94; -.
DR OMA; QMEYPYG; -.
DR OrthoDB; 981397at2759; -.
DR PhylomeDB; Q9NP94; -.
DR TreeFam; TF317098; -.
DR PathwayCommons; Q9NP94; -.
DR Reactome; R-HSA-442380; Zinc influx into cells by the SLC39 gene family.
DR SignaLink; Q9NP94; -.
DR BioGRID-ORCS; 29986; 12 hits in 1063 CRISPR screens.
DR GeneWiki; SLC39A2; -.
DR GenomeRNAi; 29986; -.
DR Pharos; Q9NP94; Tbio.
DR PRO; PR:Q9NP94; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q9NP94; protein.
DR Bgee; ENSG00000165794; Expressed in tongue squamous epithelium and 104 other tissues.
DR Genevisible; Q9NP94; HS.
DR GO; GO:0036464; C:cytoplasmic ribonucleoprotein granule; IDA:HPA.
DR GO; GO:0031410; C:cytoplasmic vesicle; IDA:UniProtKB.
DR GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR GO; GO:0005385; F:zinc ion transmembrane transporter activity; IMP:UniProtKB.
DR GO; GO:0071577; P:zinc ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0006829; P:zinc ion transport; TAS:ProtInc.
DR InterPro; IPR003689; ZIP.
DR Pfam; PF02535; Zip; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell membrane; Ion transport; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport; Zinc;
KW Zinc transport.
FT CHAIN 1..309
FT /note="Zinc transporter ZIP2"
FT /id="PRO_0000068767"
FT TOPO_DOM 1..8
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 9..29
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 30..46
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 47..67
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 68..103
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 104..124
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 125..164
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 165..185
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 186..189
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 190..210
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 211..224
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 225..245
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 246..258
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 259..279
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 280..288
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 289..309
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 83..85
FT /note="NRS -> ISK (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_046889"
FT VAR_SEQ 86..309
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_046890"
FT VARIANT 48
FT /note="L -> P (in dbSNP:rs2234633)"
FT /id="VAR_057480"
FT VARIANT 80
FT /note="M -> V (in dbSNP:rs2234634)"
FT /id="VAR_020265"
FT VARIANT 115
FT /note="F -> L (in dbSNP:rs2234636)"
FT /evidence="ECO:0000269|PubMed:10681536,
FT ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:7751801"
FT /id="VAR_055452"
FT VARIANT 129
FT /note="G -> E (in dbSNP:rs6413532)"
FT /id="VAR_020266"
FT VARIANT 154
FT /note="H -> Y (in dbSNP:rs2234637)"
FT /id="VAR_020267"
FT CONFLICT 12
FT /note="L -> P (in Ref. 5; AAH98254)"
FT /evidence="ECO:0000305"
FT CONFLICT 43
FT /note="L -> R (in Ref. 1; BAA94313, 2; AAF35832 and 5;
FT AAH96723/AAH98254/AAI10058)"
FT /evidence="ECO:0000305"
FT CONFLICT 120
FT /note="E -> V (in Ref. 3; BAG37473)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 309 AA; 32742 MW; C71A0BF8533B5D51 CRC64;
MEQLLGIKLG CLFALLALTL GCGLTPICFK WFQIDAARGH HRLVLRLLGC ISAGVFLGAG
FMHMTAEALE EIESQIQKFM VQNRSASERN SSGDADSAHM EYPYGELIIS LGFFFVFFLE
SLALQCCPGA AGGSTVQDEE WGGAHIFELH SHGHLPSPSK GPLRALVLLL SLSFHSVFEG
LAVGLQPTVA ATVQLCLAVL AHKGLVVFGV GMRLVHLGTS SRWAVFSILL LALMSPLGLA
VGLAVTGGDS EGGRGLAQAV LEGVAAGTFL YVTFLEILPR ELASPEAPLA KWSCVAAGFA
FMAFIALWA
