ID   S39A3_BOVIN             Reviewed;         314 AA.
AC   Q5E960; Q0IIM7;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Zinc transporter ZIP3;
DE   AltName: Full=Solute carrier family 39 member 3;
DE   AltName: Full=Zrt- and Irt-like protein 3;
DE            Short=ZIP-3;
GN   Name=SLC39A3; Synonyms=ZIP3;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Uterus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a zinc-influx transporter. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC       {ECO:0000305}.
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DR   EMBL; BT020718; AAX08735.1; -; mRNA.
DR   EMBL; BT021060; AAX09077.1; -; mRNA.
DR   EMBL; BC122570; AAI22571.1; -; mRNA.
DR   RefSeq; NP_001015521.1; NM_001015521.1.
DR   RefSeq; XP_005209063.1; XM_005209006.3.
DR   AlphaFoldDB; Q5E960; -.
DR   SMR; Q5E960; -.
DR   STRING; 9913.ENSBTAP00000023551; -.
DR   PaxDb; Q5E960; -.
DR   PRIDE; Q5E960; -.
DR   GeneID; 505294; -.
DR   KEGG; bta:505294; -.
DR   CTD; 29985; -.
DR   eggNOG; KOG1558; Eukaryota.
DR   HOGENOM; CLU_040462_4_1_1; -.
DR   InParanoid; Q5E960; -.
DR   OrthoDB; 981397at2759; -.
DR   TreeFam; TF317098; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005385; F:zinc ion transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0071577; P:zinc ion transmembrane transport; IBA:GO_Central.
DR   InterPro; IPR003689; ZIP.
DR   Pfam; PF02535; Zip; 1.
PE   2: Evidence at transcript level;
KW   Ion transport; Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport; Zinc; Zinc transport.
FT   CHAIN           1..314
FT                   /note="Zinc transporter ZIP3"
FT                   /id="PRO_0000312867"
FT   TOPO_DOM        1..3
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        4..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        25..42
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        43..63
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        64..85
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        86..106
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        107..169
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        170..190
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        191..196
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        197..217
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        218..229
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        230..250
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        251..262
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        263..283
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        284..292
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        293..313
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        314
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         125
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BRY0"
FT   MOD_RES         129
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q5U1X7"
FT   CONFLICT        251
FT                   /note="E -> D (in Ref. 2; AAI22571)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   314 AA;  34005 MW;  B7D2EB3D567AC53B CRC64;
     MVKLLVAKIL CMVGMFFFML LGSLLPVKII EMDFEKAHRS KKILSLCNTF GGGVFLATCF
     NALLPAVREK LKEVLTLAHI STDYPLAETI MLLGFFMTVF LEQLVLTFRK ERPAFIDLET
     FNASSDAGSD SEYESPFMGG PRGHALYAEP HGHSHGLSVQ ELSRSSPLRL LSLVFALSAH
     SVFEGLALGL QEEGEKVVSL FVGVAIHETL VAVALGINMA RSAMALRDAA KLAVTVSAMI
     PLGISLGLGI ESAQGMPSSV ASVLLQGLAG GTFLFVTFFE ILAKELEEKS DRLLKVLFLV
     LGYTVLAGMV FIKW