S39A3_MOUSE
ID S39A3_MOUSE Reviewed; 317 AA.
AC Q99K24;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Zinc transporter ZIP3;
DE AltName: Full=Solute carrier family 39 member 3;
DE AltName: Full=Zrt- and Irt-like protein 3;
DE Short=ZIP-3;
GN Name=Slc39a3; Synonyms=Zip3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Kidney, and Pancreas;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Acts as a zinc-influx transporter. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC {ECO:0000305}.
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DR EMBL; BC005502; AAH05502.1; -; mRNA.
DR CCDS; CCDS24041.1; -.
DR RefSeq; NP_598896.1; NM_134135.1.
DR AlphaFoldDB; Q99K24; -.
DR SMR; Q99K24; -.
DR STRING; 10090.ENSMUSP00000113147; -.
DR iPTMnet; Q99K24; -.
DR PhosphoSitePlus; Q99K24; -.
DR PaxDb; Q99K24; -.
DR PRIDE; Q99K24; -.
DR ProteomicsDB; 260783; -.
DR ABCD; Q99K24; 1 sequenced antibody.
DR Antibodypedia; 23039; 122 antibodies from 27 providers.
DR DNASU; 106947; -.
DR Ensembl; ENSMUST00000059551; ENSMUSP00000057094; ENSMUSG00000046822.
DR Ensembl; ENSMUST00000117276; ENSMUSP00000113147; ENSMUSG00000046822.
DR Ensembl; ENSMUST00000168076; ENSMUSP00000128256; ENSMUSG00000046822.
DR GeneID; 106947; -.
DR KEGG; mmu:106947; -.
DR UCSC; uc007gfq.1; mouse.
DR CTD; 29985; -.
DR MGI; MGI:2147269; Slc39a3.
DR VEuPathDB; HostDB:ENSMUSG00000046822; -.
DR eggNOG; KOG1558; Eukaryota.
DR GeneTree; ENSGT00940000160231; -.
DR HOGENOM; CLU_040462_4_1_1; -.
DR InParanoid; Q99K24; -.
DR OMA; HHHGHFN; -.
DR OrthoDB; 981397at2759; -.
DR PhylomeDB; Q99K24; -.
DR TreeFam; TF317098; -.
DR Reactome; R-MMU-442380; Zinc influx into cells by the SLC39 gene family.
DR BioGRID-ORCS; 106947; 1 hit in 72 CRISPR screens.
DR ChiTaRS; Slc39a3; mouse.
DR PRO; PR:Q99K24; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q99K24; protein.
DR Bgee; ENSMUSG00000046822; Expressed in embryonic brain and 241 other tissues.
DR ExpressionAtlas; Q99K24; baseline and differential.
DR Genevisible; Q99K24; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005385; F:zinc ion transmembrane transporter activity; IDA:MGI.
DR GO; GO:0000902; P:cell morphogenesis; IMP:MGI.
DR GO; GO:0048701; P:embryonic cranial skeleton morphogenesis; IGI:MGI.
DR GO; GO:0001701; P:in utero embryonic development; IGI:MGI.
DR GO; GO:0060173; P:limb development; IGI:MGI.
DR GO; GO:0043029; P:T cell homeostasis; IMP:MGI.
DR GO; GO:0071577; P:zinc ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0006829; P:zinc ion transport; IDA:MGI.
DR InterPro; IPR003689; ZIP.
DR Pfam; PF02535; Zip; 1.
PE 1: Evidence at protein level;
KW Ion transport; Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport; Zinc; Zinc transport.
FT CHAIN 1..317
FT /note="Zinc transporter ZIP3"
FT /id="PRO_0000312869"
FT TOPO_DOM 1..3
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 4..24
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 25..42
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 43..63
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 64..85
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 86..106
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 107..172
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 173..193
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 194..199
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 200..220
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 221..232
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 233..253
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 254..265
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 266..286
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 287..294
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 295..315
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 316..317
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT MOD_RES 125
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9BRY0"
FT MOD_RES 129
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5U1X7"
SQ SEQUENCE 317 AA; 34002 MW; E6F72B1783F99B63 CRC64;
MTKLLVAKVL CMVGVFFFML LGSLLPVKVI EADLEKAHRS KKVLSLCNTF GGGVFLATCF
NALLPAVRDK LQQVLSLGHI STDYPLAETL MMVGFFLTVF VEQLVLTFRR ERPPFIDLET
FNAGSDAGSD SEYESPFVGV GNRSHSLYPE PTAHTHGAGL RLRELGRPGP LRLLSLVFAL
SAHSVFEGLA LGLQEEGERV VSLFVGVAIH ETLVAVALGI SMARSAVPLR DAAKLAVTVS
AMIPVGIGLG LGIESARSVA SSVASALLQG LAGGTFLFVT FLEILAKELE ERSEQLLKVL
FLVLGYAVLA GMVFLKW
