S39A3_RAT
ID S39A3_RAT Reviewed; 317 AA.
AC Q5U1X7;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 07-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Zinc transporter ZIP3;
DE AltName: Full=Solute carrier family 39 member 3;
DE AltName: Full=Zrt- and Irt-like protein 3;
DE Short=ZIP-3;
GN Name=Slc39a3; Synonyms=Zip3;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-125 AND SER-129, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903; DOI=10.1038/ncomms1871;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
CC -!- FUNCTION: Acts as a zinc-influx transporter. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC {ECO:0000305}.
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DR EMBL; BC086411; AAH86411.1; -; mRNA.
DR RefSeq; NP_001008357.1; NM_001008356.1.
DR AlphaFoldDB; Q5U1X7; -.
DR SMR; Q5U1X7; -.
DR BioGRID; 260787; 2.
DR STRING; 10116.ENSRNOP00000066970; -.
DR iPTMnet; Q5U1X7; -.
DR PhosphoSitePlus; Q5U1X7; -.
DR PaxDb; Q5U1X7; -.
DR PRIDE; Q5U1X7; -.
DR ABCD; Q5U1X7; 1 sequenced antibody.
DR Ensembl; ENSRNOT00000073221; ENSRNOP00000066970; ENSRNOG00000045524.
DR GeneID; 314637; -.
DR KEGG; rno:314637; -.
DR UCSC; RGD:1310863; rat.
DR CTD; 29985; -.
DR RGD; 1310863; Slc39a3.
DR eggNOG; KOG1558; Eukaryota.
DR GeneTree; ENSGT00940000160231; -.
DR HOGENOM; CLU_040462_4_1_1; -.
DR InParanoid; Q5U1X7; -.
DR OMA; HHHGHFN; -.
DR OrthoDB; 981397at2759; -.
DR PhylomeDB; Q5U1X7; -.
DR TreeFam; TF317098; -.
DR Reactome; R-RNO-442380; Zinc influx into cells by the SLC39 gene family.
DR PRO; PR:Q5U1X7; -.
DR Proteomes; UP000002494; Chromosome 7.
DR Bgee; ENSRNOG00000045524; Expressed in testis and 19 other tissues.
DR Genevisible; Q5U1X7; RN.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005385; F:zinc ion transmembrane transporter activity; ISO:RGD.
DR GO; GO:0000902; P:cell morphogenesis; ISO:RGD.
DR GO; GO:0048701; P:embryonic cranial skeleton morphogenesis; ISO:RGD.
DR GO; GO:0001701; P:in utero embryonic development; ISO:RGD.
DR GO; GO:0060173; P:limb development; ISO:RGD.
DR GO; GO:0043029; P:T cell homeostasis; ISO:RGD.
DR GO; GO:0071577; P:zinc ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0006829; P:zinc ion transport; ISO:RGD.
DR InterPro; IPR003689; ZIP.
DR Pfam; PF02535; Zip; 1.
PE 1: Evidence at protein level;
KW Ion transport; Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport; Zinc; Zinc transport.
FT CHAIN 1..317
FT /note="Zinc transporter ZIP3"
FT /id="PRO_0000312870"
FT TOPO_DOM 1..3
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 4..24
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 25..42
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 43..63
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 64..85
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 86..106
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 107..172
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 173..193
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 194..199
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 200..220
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 221..232
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 233..253
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 254..265
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 266..286
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 287..294
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 295..315
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 316..317
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT MOD_RES 125
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT MOD_RES 129
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
SQ SEQUENCE 317 AA; 33964 MW; 43CA6D10134F3C10 CRC64;
MSQLLVAKVL CMVGVFFFML LGSLLPVKVI EADFEKAHRS KKVLSLCNTF GGGVFLATCF
NALLPAVRDK LQQVLSLGHI STDYPLAETL MMVGFFLTVF VEQLVLTFRR ERPPFIDLET
FNAGSDAGSD SEYESPFVGV GGRNHGLYPE PTAHSHGTGL RLRELGRPGP LRLLSLVFAL
SAHSVFEGLA LGLQEEGERV VSLFVGVAVH ETLVAVALGI SMARSAVPLR DAAKLAVTVS
AMIPVGIGLG LGIESARSVA SSVASALLQG LAGGTFLFVT FLEILAKELE ERSEQLLKVL
FLVLGYAVLA GMVFLKW
