ID   S39A3_XENTR             Reviewed;         314 AA.
AC   A4IIC5;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 57.
DE   RecName: Full=Zinc transporter ZIP3;
DE   AltName: Full=Solute carrier family 39 member 3;
DE   AltName: Full=Zrt- and Irt-like protein 3;
DE            Short=ZIP-3;
GN   Name=slc39a3; Synonyms=zip3;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a zinc-influx transporter. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC       {ECO:0000305}.
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DR   EMBL; BC135963; AAI35964.1; -; mRNA.
DR   RefSeq; NP_001096167.1; NM_001102697.1.
DR   AlphaFoldDB; A4IIC5; -.
DR   SMR; A4IIC5; -.
DR   STRING; 8364.ENSXETP00000008023; -.
DR   PaxDb; A4IIC5; -.
DR   DNASU; 100124712; -.
DR   GeneID; 100124712; -.
DR   KEGG; xtr:100124712; -.
DR   CTD; 29985; -.
DR   Xenbase; XB-GENE-969593; slc39a3.
DR   eggNOG; KOG1558; Eukaryota.
DR   InParanoid; A4IIC5; -.
DR   OrthoDB; 981397at2759; -.
DR   Proteomes; UP000008143; Chromosome 1.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005385; F:zinc ion transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0071577; P:zinc ion transmembrane transport; IBA:GO_Central.
DR   InterPro; IPR003689; ZIP.
DR   Pfam; PF02535; Zip; 1.
PE   2: Evidence at transcript level;
KW   Ion transport; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport; Zinc; Zinc transport.
FT   CHAIN           1..314
FT                   /note="Zinc transporter ZIP3"
FT                   /id="PRO_0000312871"
FT   TOPO_DOM        1..3
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        4..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        25..41
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        42..62
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        63..84
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        85..105
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        106..169
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        170..190
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        191..196
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        197..217
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        218..229
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        230..250
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        251..262
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        263..283
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        284..292
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        293..313
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        314
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   314 AA;  34231 MW;  A09A62C7774B5B4C CRC64;
     MNLIFAKVLC LLAILVLMML GSLIPVKISE ADFDKSSRSR KILSLSNSFA GGVFLATCFN
     ALLPAVREKF FDLLKIGNIS TDYPLAETIM MVGFFLTVFV EQTVMTFRKE KPSFIDMETF
     NAGSDIGSDS EFESPFISAN HGHNLYEGGH SHHSHSLNIK ELSSSSPIRL FSLVFALSAH
     SVFEGLALGL QEDGNKLLSL FIGVVIHETL VAMALGVSMA KVNTHLKDAI KMAVLVSTMI
     PIGIVVGMAI QSAQNMASSI ASALLQGIAG GTFIFVTFFE ILVKELEEKN DRLLKVLFLV
     LGYTVLAVLV LFKW