S39A4_BOVIN
ID S39A4_BOVIN Reviewed; 653 AA.
AC Q1KZG0; Q1KZF9;
DT 20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2006, sequence version 1.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Zinc transporter ZIP4;
DE AltName: Full=Solute carrier family 39 member 4;
DE AltName: Full=Zrt- and Irt-like protein 4;
DE Short=ZIP-4;
DE Flags: Precursor;
GN Name=SLC39A4 {ECO:0000312|EMBL:ABC69723.1};
GN Synonyms=ZIP4 {ECO:0000250|UniProtKB:Q6P5W5};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1] {ECO:0000305, ECO:0000312|EMBL:ABC69723.1}
RP NUCLEOTIDE SEQUENCE [MRNA], VARIANT BHZD 499-LEU--GLY-549 DEL, AND DISEASE.
RX PubMed=16714095; DOI=10.1016/j.ygeno.2006.03.018;
RA Yuzbasiyan-Gurkan V., Bartlett E.;
RT "Identification of a unique splice site variant in SLC39A4 in bovine
RT hereditary zinc deficiency, lethal trait A46: an animal model of
RT acrodermatitis enteropathica.";
RL Genomics 88:521-526(2006).
RN [2] {ECO:0000312|EMBL:AAI16013.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford {ECO:0000312|EMBL:AAI16013.1};
RC TISSUE=Ascending colon {ECO:0000312|EMBL:AAI16013.1};
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays an important role in cellular zinc homeostasis as a
CC zinc transporter. Regulated in response to zinc availability (By
CC similarity). {ECO:0000250|UniProtKB:Q78IQ7}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q78IQ7};
CC Multi-pass membrane protein {ECO:0000250|UniProtKB:Q78IQ7}. Recycling
CC endosome membrane {ECO:0000250}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:Q78IQ7}. Note=Colocalized with TFRC in the
CC recycling endosomes. Cycles between endosomal compartments and the
CC plasma membrane in response to zinc availability (By similarity).
CC {ECO:0000250|UniProtKB:Q78IQ7}.
CC -!- DISEASE: Note=Defects in SLC39A4 are the cause of bovine hereditary
CC zinc-deficiency (BHZD); also known as lethal trait A46, Adema disease,
CC hereditary parakeratosis, and hereditary thymus hypoplasia. BHZD is a
CC autosomal recessive disease caused by the inability to absorb
CC sufficient zinc. The symptoms are diarrhea, immune system dysfunction,
CC skin lesions and death if untreated. Oral zinc supplementation allows
CC symptom free development of calves (PubMed:16714095).
CC {ECO:0000269|PubMed:16714095}.
CC -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC {ECO:0000255}.
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DR EMBL; DQ336345; ABC69723.1; -; mRNA.
DR EMBL; DQ336346; ABC69724.1; -; mRNA.
DR EMBL; BC116012; AAI16013.1; -; mRNA.
DR RefSeq; NP_001039532.1; NM_001046067.1.
DR AlphaFoldDB; Q1KZG0; -.
DR SMR; Q1KZG0; -.
DR STRING; 9913.ENSBTAP00000012255; -.
DR PaxDb; Q1KZG0; -.
DR PRIDE; Q1KZG0; -.
DR Ensembl; ENSBTAT00000012255; ENSBTAP00000012255; ENSBTAG00000046026.
DR GeneID; 510951; -.
DR KEGG; bta:510951; -.
DR CTD; 55630; -.
DR VEuPathDB; HostDB:ENSBTAG00000046026; -.
DR VGNC; VGNC:34864; SLC39A4.
DR eggNOG; KOG2693; Eukaryota.
DR GeneTree; ENSGT00940000160042; -.
DR HOGENOM; CLU_015114_12_0_1; -.
DR InParanoid; Q1KZG0; -.
DR OrthoDB; 657777at2759; -.
DR TreeFam; TF318470; -.
DR Proteomes; UP000009136; Chromosome 14.
DR Bgee; ENSBTAG00000046026; Expressed in conceptus and 38 other tissues.
DR ExpressionAtlas; Q1KZG0; baseline and differential.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0055038; C:recycling endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005385; F:zinc ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0006882; P:cellular zinc ion homeostasis; IBA:GO_Central.
DR GO; GO:0071578; P:zinc ion import across plasma membrane; IBA:GO_Central.
DR InterPro; IPR003689; ZIP.
DR InterPro; IPR041137; ZIP4_N.
DR Pfam; PF02535; Zip; 1.
DR Pfam; PF18292; ZIP4_domain; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Disease variant; Endosome; Glycoprotein; Ion transport;
KW Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix;
KW Transport; Zinc; Zinc transport.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..653
FT /note="Zinc transporter ZIP4"
FT /evidence="ECO:0000255"
FT /id="PRO_0000278125"
FT TOPO_DOM 27..334
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 335..355
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 356..366
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 367..387
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 388..402
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 403..423
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 424..563
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 564..584
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 585..593
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 594..614
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 615..623
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 624..644
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 645..653
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT REGION 239..267
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 472..493
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 223
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 267
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 499..549
FT /note="Missing (in BHZD)"
FT /evidence="ECO:0000269|PubMed:16714095"
SQ SEQUENCE 653 AA; 68620 MW; 07DD241894E93BCF CRC64;
MALLGRPGLG PLLAVLAALA ASGTTTRPVH LLTLLSSGQG ALDRVALGGL LNTLAARVHC
ADGPCGKCLS VDDALALGRP EQPGAPSGQV LEPRHIARLS AAAALYLSDP AGTCAEVRAG
RWAARADQLL VLLESSQALS VALTRLLQQI QARAAGQPTS QQACVDLPQL LGEAAGIGAP
GSPGPVLAAL LGHVWSGACF HALPTPQYFV DFVFRQHSSE NPNITLDELA ALMERLGLGG
ATEPHDSHSD DSPLGKGQGP VPLAAPNSSA SAWDTLCLSA QDIMAVYGMS EQAGVTPDDW
ARLSPALLQQ QLSGACSPQP TLPTQDQLSQ AERYLYGSLA TLLICLCSLL GLLLLSCASC
STTSHYIIQA FLSMAVGALT GDALLHLMPK VLGLHTHDGE DHGFQPTWHL LAVLGGLYAF
FLFERLFNLL LPLDPEDPKD GACSHGHSHG GHSHGVSLQL APSDFRQPKQ LHEGSRADLV
AEESPELLSP EPRRRSPGLR LLPYVITLGD AVHNFADGLA VGAAFLSSWK TGLATSLAVF
CHEVPHELGD FAALLHAGLS VRRALLLNVA SALTAFIGLY VALAAGVGED GETWILAVAA
GLFLYVALCD MLPAMLNVRD RRPWLLFLLH NVGLLGGWTV LLLLSLYEDN IAF
