S39A4_RAT
ID S39A4_RAT Reviewed; 656 AA.
AC A0JPN2;
DT 20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 12-DEC-2006, sequence version 1.
DT 25-MAY-2022, entry version 93.
DE RecName: Full=Zinc transporter ZIP4;
DE AltName: Full=Solute carrier family 39 member 4;
DE AltName: Full=Zrt- and Irt-like protein 4;
DE Short=ZIP-4;
DE Flags: Precursor;
GN Name=Slc39a4 {ECO:0000312|EMBL:AAI27515.1};
GN Synonyms=Zip4 {ECO:0000250|UniProtKB:Q6P5W5};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1] {ECO:0000312|EMBL:AAI27515.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung {ECO:0000312|EMBL:AAI27515.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Plays an important role in cellular zinc homeostasis as a
CC zinc transporter. Regulated in response to zinc availability (By
CC similarity). {ECO:0000250|UniProtKB:Q78IQ7}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q78IQ7};
CC Multi-pass membrane protein {ECO:0000250|UniProtKB:Q78IQ7}. Recycling
CC endosome membrane {ECO:0000250}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:Q78IQ7}. Note=Colocalized with TFRC in the
CC recycling endosomes. Cycles between endosomal compartments and the
CC plasma membrane in response to zinc availability (By similarity).
CC {ECO:0000250|UniProtKB:Q78IQ7}.
CC -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC {ECO:0000255}.
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DR EMBL; BC127514; AAI27515.1; -; mRNA.
DR RefSeq; NP_001071137.1; NM_001077669.1.
DR AlphaFoldDB; A0JPN2; -.
DR SMR; A0JPN2; -.
DR STRING; 10116.ENSRNOP00000047376; -.
DR GlyGen; A0JPN2; 3 sites.
DR PhosphoSitePlus; A0JPN2; -.
DR PaxDb; A0JPN2; -.
DR PeptideAtlas; A0JPN2; -.
DR GeneID; 300051; -.
DR KEGG; rno:300051; -.
DR UCSC; RGD:1306701; rat.
DR CTD; 55630; -.
DR RGD; 1306701; Slc39a4.
DR eggNOG; KOG2693; Eukaryota.
DR HOGENOM; CLU_015114_12_1_1; -.
DR InParanoid; A0JPN2; -.
DR OMA; IFFLFES; -.
DR PhylomeDB; A0JPN2; -.
DR TreeFam; TF318470; -.
DR Reactome; R-RNO-442380; Zinc influx into cells by the SLC39 gene family.
DR PRO; PR:A0JPN2; -.
DR Proteomes; UP000002494; Unplaced.
DR Genevisible; A0JPN2; RN.
DR GO; GO:0016324; C:apical plasma membrane; ISO:RGD.
DR GO; GO:0031410; C:cytoplasmic vesicle; ISS:UniProtKB.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0055038; C:recycling endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005385; F:zinc ion transmembrane transporter activity; ISO:RGD.
DR GO; GO:0034224; P:cellular response to zinc ion starvation; ISO:RGD.
DR GO; GO:0006882; P:cellular zinc ion homeostasis; IBA:GO_Central.
DR GO; GO:0071578; P:zinc ion import across plasma membrane; IBA:GO_Central.
DR InterPro; IPR003689; ZIP.
DR InterPro; IPR041137; ZIP4_N.
DR Pfam; PF02535; Zip; 1.
DR Pfam; PF18292; ZIP4_domain; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Endosome; Glycoprotein; Ion transport; Membrane;
KW Reference proteome; Signal; Transmembrane; Transmembrane helix; Transport;
KW Zinc; Zinc transport.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..656
FT /note="Zinc transporter ZIP4"
FT /evidence="ECO:0000255"
FT /id="PRO_0000278126"
FT TOPO_DOM 22..334
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 335..355
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 356..373
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 374..394
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 395..416
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 417..437
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 438..567
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 568..588
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 589..596
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 597..617
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 618..626
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 627..647
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 648..656
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT REGION 466..490
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 192
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 219
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 267
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 656 AA; 71121 MW; F1DD0D0CE8513120 CRC64;
MLPKSLTQGL LLAMLVGTAA MVQPYHLLSL LTSGQGALDR TALDGLLNTL VARVHCTDGP
CEKCLSVETA LALGKPDKPQ LAPESVLESR YITYLSAAAA LYLNDPEKTC KDIRAGLLAS
HVDDYLAKLE SPEAMTLGLS QLLQKIEAHD ASQPTREETC VDVPQLLEEA EEAGVSRSPG
LVLTALLDHV LNGSCFQGLP SPQYFVDFVF RQLSSKPRNI TLPELEDLMH HLGVGGEDHS
DHGDHVDHSH LDREANHQDS ELHATHNSSS SVWDTLCLSA KDVMAVYGLS EEAGVSPQAW
AQLTPALVQQ QLSEACSSSP IIHVQDQLSQ AERYLYGSLA TLLICLCAVF GLLLLTCAKC
STATHYIMQT FLSLAVGALT GDALLHLIPK VLGLHTHSGE VHSHEEESIG GQSTWRLLAV
LGGFYIFFLF ESFFNLLLPR DQDHEKDGPC SHGGHSHGIS LQLSPSNLRQ SKQPHESSRS
DLVTEETPEL LNPDTRRLRA ELRMLPYLIT LGDAVHNFAD GLAVGAAFSS TWKTGLATSL
AVFCHELPHE LGDFAALLHA GLTVKRALLL NLASALTAFA GLYVALAVGV GEEGETWILA
VATGLFLYVA LCDMLPAMMN VRDQRPWLLF LLHNVGLLGG WTILLLLSLY EDSITF
