S39A6_PONAB
ID S39A6_PONAB Reviewed; 743 AA.
AC Q5R9M9;
DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 25-MAY-2022, entry version 74.
DE RecName: Full=Zinc transporter ZIP6;
DE AltName: Full=Solute carrier family 39 member 6;
DE AltName: Full=Zrt- and Irt-like protein 6;
DE Short=ZIP-6;
DE Flags: Precursor;
GN Name=SLC39A6; Synonyms=ZIP6;
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RG The German cDNA consortium;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May act as a zinc-influx transporter. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- PTM: N-glycosylated. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC {ECO:0000305}.
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DR EMBL; CR859357; CAH91531.1; -; mRNA.
DR RefSeq; NP_001125899.1; NM_001132427.1.
DR AlphaFoldDB; Q5R9M9; -.
DR SMR; Q5R9M9; -.
DR STRING; 9601.ENSPPYP00000010233; -.
DR GeneID; 100172832; -.
DR KEGG; pon:100172832; -.
DR CTD; 25800; -.
DR eggNOG; KOG2693; Eukaryota.
DR InParanoid; Q5R9M9; -.
DR Proteomes; UP000001595; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031258; C:lamellipodium membrane; ISS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0046873; F:metal ion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0071577; P:zinc ion transmembrane transport; ISS:UniProtKB.
DR InterPro; IPR003689; ZIP.
DR Pfam; PF02535; Zip; 2.
PE 2: Evidence at transcript level;
KW Cell membrane; Coiled coil; Glycoprotein; Ion transport; Membrane;
KW Phosphoprotein; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix; Transport; Zinc; Zinc transport.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..743
FT /note="Zinc transporter ZIP6"
FT /id="PRO_0000041652"
FT TOPO_DOM 21..313
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 314..334
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 335..343
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 344..364
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 365..411
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 412..432
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 433..645
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 646..666
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 667..674
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 675..695
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 696..712
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 713..733
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 734..743
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT REGION 96..174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 190..245
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 452..474
FT /evidence="ECO:0000255"
FT COMPBIAS 96..120
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 129..165
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 459
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q13433"
FT MOD_RES 466
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q13433"
FT CARBOHYD 67
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 229
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 254
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 271
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 672
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 743 AA; 83607 MW; 6BBE0A1D1AEAAA9E CRC64;
MARKLSVILI LTFALSVTNP LHELKAAAFP QTTEKISPNW ESGINVDLAI TTRQYHLQQL
FYRYGENNSL SVEGFRKLLQ NIGIDKIKRI HIHHDHEHHS DHEHHSDHEH HSDHEHHSHR
NHAASGKNKR KALCPDHDSD SSGKDPRNSQ GKGAHRSEHA SGRRNVKDSV SASEVTSTVY
NTVSEGTHFL ETIETPRPGK LFPKDVSSST PPSVTEKSRG SRLAGRKTNE SVSEPRKGFM
YSRNTNENPQ ECFNASKLLT SHGMGIQVPL NATEFNYLCP AIINQIDARS CLIHTSEKKA
EIPPKTYSLQ IAWVGGFIAI SIISFLSLLG VILVPLMNRV FFKFLLSFLV ALAVGTLSGD
AFLHLLPHSH ASHHHSHSHE EPAMEMKRGP LFSHLSSQNI EESAYFDSTW KGLTALGGLY
FMFLVEHVLT LIKQFKDKKK KNQKKPENDD DVEIKKQLSK YESQLSTNEE KVDTDDRTEG
YLRADSQEPS HFDSQQPAIL EEEEVMIAHA HPQEVYNEYV PRGCKNKCHS HFHDTLGQSD
DLIHHHHDYH HILHHHHHQN HHPHSHSQRY SREELKDAGI ATLAWMVIMG DGLHNFSDGL
AIGAAFTEGL SSGLSTSVAV FCHELPHELG DFAVLLKAGM TVKQAVLYNA LSAMLAYLGM
ATGIFIGHYA ENVSMWIFAL TAGLFMYVAL VDMVPEMLHN DASDHGCSRW GYFFLQNAGM
LLGFGIMLLI SIFEHKIVFR INF
