ID   S39A7_DANRE             Reviewed;         352 AA.
AC   Q9PUB8;
DT   24-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Zinc transporter Slc39a7;
DE   AltName: Full=Histidine-rich membrane protein Ke4;
DE   AltName: Full=Solute carrier family 39 member 7;
DE   AltName: Full=Zrt-, Irt-like protein 7;
DE            Short=ZIP7;
DE   Flags: Fragment;
GN   Name=slc39a7; Synonyms=hke4, ke4;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Murray B.W., Sueltmann H., Klein J.;
RT   "Identification of a homolog of the human HKE4 gene in zebrafish.";
RL   Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Zinc transporter, that transports Zn(2+) from the endoplasmic
CC       reticulum/Golgi apparatus to the cytosol. Transport is stimulated by
CC       growth factors, such as EGF, and Ca(2+), as well as by exogenous
CC       Zn(2+). {ECO:0000250|UniProtKB:Q92504}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q92504}; Multi-pass membrane protein
CC       {ECO:0000255}. Golgi apparatus, cis-Golgi network membrane
CC       {ECO:0000250|UniProtKB:Q92504}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC       KE4/Catsup subfamily. {ECO:0000305}.
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DR   EMBL; AF196345; AAF05821.1; -; mRNA.
DR   AlphaFoldDB; Q9PUB8; -.
DR   STRING; 7955.ENSDARP00000052863; -.
DR   PaxDb; Q9PUB8; -.
DR   ZFIN; ZDB-GENE-991110-20; slc39a7.
DR   eggNOG; KOG2693; Eukaryota.
DR   InParanoid; Q9PUB8; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005385; F:zinc ion transmembrane transporter activity; ISS:ZFIN.
DR   GO; GO:0006882; P:cellular zinc ion homeostasis; IBA:GO_Central.
DR   GO; GO:0055069; P:zinc ion homeostasis; IMP:ZFIN.
DR   GO; GO:0071577; P:zinc ion transmembrane transport; IBA:GO_Central.
DR   GO; GO:0006829; P:zinc ion transport; ISS:ZFIN.
DR   InterPro; IPR003689; ZIP.
DR   Pfam; PF02535; Zip; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Golgi apparatus; Ion transport; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport; Zinc;
KW   Zinc transport.
FT   CHAIN           1..>352
FT                   /note="Zinc transporter Slc39a7"
FT                   /id="PRO_0000213692"
FT   TRANSMEM        3..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        128..148
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        161..181
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        215..235
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        318..338
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          24..112
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          185..214
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          245..292
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        58..112
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        185..212
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        254..284
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         352
SQ   SEQUENCE   352 AA;  37922 MW;  C8C8C60F6D2BA8A6 CRC64;
     MRVFSKSLLL IAVGILMSQQ TLAHSHHHHG HGDGGCHGHS HGGAKMHHGA SKWSAEANLP
     HAEEEHHVHD HGHTHDHAHD HGHAHSHGDI HDHGHAHKHG HAHDHGAEKS KKVVEAGKRN
     MVELWMQAIG ATLLISAAPF LILFLIPVQS NTDQHQNLLK VLLSFASGGL LGDAFLHLIP
     HALEPHSHHS QPHSEESHGQ SHGEESHGHS HGAAHGHMMS VGLWVLGGIV AFLVVEKFVR
     LLKGGHSHSH SHSPSAPKSK DSDEEDDKKG QKKGEKDKVV SQQKPTKKTV ETSSDIKVSG
     YLNLAADFTH NFTDGLAIGA SFLVGPAVGA VTTITILLHE VPHEIGDFAI LV