S39A7_PIG
ID S39A7_PIG Reviewed; 155 AA.
AC Q29175; Q9XT01;
DT 24-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT 24-JAN-2001, sequence version 2.
DT 25-MAY-2022, entry version 83.
DE RecName: Full=Zinc transporter SLC39A7;
DE AltName: Full=Histidine-rich membrane protein Ke4;
DE AltName: Full=Solute carrier family 39 member 7;
DE AltName: Full=Zrt-, Irt-like protein 7;
DE Short=ZIP7;
DE Flags: Fragments;
GN Name=SLC39A7; Synonyms=HKE4;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-124.
RC TISSUE=Small intestine;
RX PubMed=8672129; DOI=10.1007/s003359900153;
RA Winteroe A.K., Fredholm M., Davies W.;
RT "Evaluation and characterization of a porcine small intestine cDNA library:
RT analysis of 839 clones.";
RL Mamm. Genome 7:509-517(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 125-155.
RC STRAIN=Belgian Landrace;
RA Chardon P., Rogel-Gaillard C., Peelman L.J., Yerle M., Renard C.,
RA Vaiman M.;
RT "Physical organization of the swine major histocompatibility complex class
RT II region.";
RL Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Zinc transporter, that transports Zn(2+) from the endoplasmic
CC reticulum/Golgi apparatus to the cytosol. Transport is stimulated by
CC growth factors, such as EGF, and Ca(2+), as well as by exogenous
CC Zn(2+). {ECO:0000250|UniProtKB:Q92504}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000250|UniProtKB:Q92504}; Multi-pass membrane protein
CC {ECO:0000255}. Golgi apparatus, cis-Golgi network membrane
CC {ECO:0000250|UniProtKB:Q92504}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- PTM: Methylation at some His residue by METTL9 leads to reduced zinc-
CC binding. {ECO:0000250|UniProtKB:Q92504}.
CC -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC KE4/Catsup subfamily. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; F14787; CAA23256.1; -; mRNA.
DR EMBL; AF146397; AAD44801.1; -; Genomic_DNA.
DR AlphaFoldDB; Q29175; -.
DR SMR; Q29175; -.
DR PRIDE; Q29175; -.
DR InParanoid; Q29175; -.
DR Proteomes; UP000008227; Unplaced.
DR Proteomes; UP000314985; Unplaced.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005385; F:zinc ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0006882; P:cellular zinc ion homeostasis; IBA:GO_Central.
DR GO; GO:0071577; P:zinc ion transmembrane transport; IBA:GO_Central.
PE 2: Evidence at transcript level;
KW Endoplasmic reticulum; Golgi apparatus; Ion transport; Membrane;
KW Methylation; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport; Zinc; Zinc transport.
FT CHAIN <1..>155
FT /note="Zinc transporter SLC39A7"
FT /id="PRO_0000213690"
FT TRANSMEM 19..39
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 47..114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 75..109
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 79
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q92504"
FT MOD_RES 80
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q92504"
FT NON_CONS 124..125
FT /evidence="ECO:0000305"
FT NON_TER 1
FT NON_TER 155
SQ SEQUENCE 155 AA; 16840 MW; 56354DE3CAAE4524 CRC64;
HSHHPLEQPR HGHSHSGQGP ILSVGLWVLS GIVAFLVVEK FVRHVKGGHG HSHGHGHAHG
TRMEVMAWKT GVSSKEKQSS EEEEKEAGAS RKRRGGSTRP KDGPVRPQHS GEEKQGQTCV
CQGIILTTMT VLLHEVPHEV GDFAILVQSG CSKKQ
