ID   BEST2_CAEEL             Reviewed;         421 AA.
AC   Q17529;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   22-SEP-2009, sequence version 2.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=Bestrophin homolog 2;
GN   Name=best-2; ORFNames=B0564.4;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Forms chloride channels. {ECO:0000250}.
CC   -!- SUBUNIT: Forms oligomers. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the bestrophin family. {ECO:0000305}.
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DR   EMBL; Z73422; CAA97766.2; -; Genomic_DNA.
DR   PIR; T18782; T18782.
DR   RefSeq; NP_502524.2; NM_070123.2.
DR   AlphaFoldDB; Q17529; -.
DR   SMR; Q17529; -.
DR   STRING; 6239.B0564.4; -.
DR   PaxDb; Q17529; -.
DR   EnsemblMetazoa; B0564.4.1; B0564.4.1; WBGene00007204.
DR   GeneID; 182044; -.
DR   KEGG; cel:CELE_B0564.4; -.
DR   UCSC; B0564.4; c. elegans.
DR   CTD; 182044; -.
DR   WormBase; B0564.4; CE43147; WBGene00007204; best-2.
DR   eggNOG; KOG3547; Eukaryota.
DR   GeneTree; ENSGT00970000196575; -.
DR   HOGENOM; CLU_018069_7_1_1; -.
DR   InParanoid; Q17529; -.
DR   OMA; TAYMESQ; -.
DR   OrthoDB; 279144at2759; -.
DR   PhylomeDB; Q17529; -.
DR   Reactome; R-CEL-2672351; Stimuli-sensing channels.
DR   PRO; PR:Q17529; -.
DR   Proteomes; UP000001940; Chromosome IV.
DR   GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005254; F:chloride channel activity; IBA:GO_Central.
DR   InterPro; IPR000615; Bestrophin.
DR   InterPro; IPR021134; Bestrophin/UPF0187.
DR   PANTHER; PTHR10736; PTHR10736; 1.
DR   Pfam; PF01062; Bestrophin; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Chloride; Chloride channel; Ion channel; Ion transport;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..421
FT                   /note="Bestrophin homolog 2"
FT                   /id="PRO_0000143125"
FT   TRANSMEM        28..48
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        73..93
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        239..259
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        275..295
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   421 AA;  49985 MW;  B6767DAC74BF29DF CRC64;
     MTINYHKEIK TSHTWKFFVL LFRWKGSIWK AIYMETIIFL ICYGIISVVY RTAMSEPSQR
     TFESVIRYCD KRLSFIPLEF VLGFFVTIVV DRWTKLWRTV GFIDDVCLLA NLYVRGTSEK
     AIIYRRNIAR YCALTQLLVF RDVSMRTRRR FPTMETVVAA GFMSKDELDL YNSYTTKNNS
     RLGKKYWIPA NWALCMTYKA RKDGYIESDY FKAQMEGEIR TWRTNIEWVC NYDWVPLPLM
     YPQLVCLAVN LYFLVSIIAR QLVIEKHKMV DEVDVYFPVM TFLQFIFYMG WLKVIEVMLN
     PFGEDDDDFE TNALIDRNIT MGLKMVDNTM KTPELLKDQF FDEVLVSLLY SEESSQISNY
     HYHGSTSEVH LEQKCSSVRM IPHSQSEYTL KHMRKQTLSR SVLPDVNENE RWKIPTSLEK
     F