S39A9_HUMAN
ID S39A9_HUMAN Reviewed; 307 AA.
AC Q9NUM3; G3V5J8; Q53HN3; Q5MJQ0; Q6P2Q1; Q86WY2;
DT 21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-AUG-2007, sequence version 2.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Zinc transporter ZIP9;
DE AltName: Full=Solute carrier family 39 member 9;
DE AltName: Full=Zrt- and Irt-like protein 9;
DE Short=ZIP-9;
GN Name=SLC39A9; Synonyms=ZIP9; ORFNames=UNQ714/PRO1377;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Placenta;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT THR-221.
RA Lin L., Zhong G., Ke R., Li H., Shen C., Nong W., Zhou G., Yang S.;
RL Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORM 3).
RX PubMed=12508121; DOI=10.1038/nature01348;
RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA Waterston R., Hood L., Weissenbach J.;
RT "The DNA sequence and analysis of human chromosome 14.";
RL Nature 421:601-607(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT CYS-285.
RC TISSUE=Duodenum, and Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May act as a zinc-influx transporter. {ECO:0000250}.
CC -!- INTERACTION:
CC Q9NUM3; Q86W74-2: ANKRD46; NbExp=3; IntAct=EBI-2823239, EBI-12109402;
CC Q9NUM3; Q96BI3: APH1A; NbExp=3; IntAct=EBI-2823239, EBI-2606935;
CC Q9NUM3; Q13520: AQP6; NbExp=3; IntAct=EBI-2823239, EBI-13059134;
CC Q9NUM3; Q12982: BNIP2; NbExp=3; IntAct=EBI-2823239, EBI-752094;
CC Q9NUM3; Q8N350-4: CBARP; NbExp=3; IntAct=EBI-2823239, EBI-19051169;
CC Q9NUM3; P11912: CD79A; NbExp=3; IntAct=EBI-2823239, EBI-7797864;
CC Q9NUM3; Q8IU89: CERS3; NbExp=3; IntAct=EBI-2823239, EBI-18202821;
CC Q9NUM3; Q7Z7G2: CPLX4; NbExp=3; IntAct=EBI-2823239, EBI-18013275;
CC Q9NUM3; Q9BUF7-2: CRB3; NbExp=3; IntAct=EBI-2823239, EBI-17233035;
CC Q9NUM3; Q96BA8: CREB3L1; NbExp=3; IntAct=EBI-2823239, EBI-6942903;
CC Q9NUM3; Q68CJ9: CREB3L3; NbExp=3; IntAct=EBI-2823239, EBI-852194;
CC Q9NUM3; O43169: CYB5B; NbExp=3; IntAct=EBI-2823239, EBI-1058710;
CC Q9NUM3; Q9NYP7: ELOVL5; NbExp=3; IntAct=EBI-2823239, EBI-11037623;
CC Q9NUM3; P34910-2: EVI2B; NbExp=3; IntAct=EBI-2823239, EBI-17640610;
CC Q9NUM3; O15552: FFAR2; NbExp=3; IntAct=EBI-2823239, EBI-2833872;
CC Q9NUM3; P48165: GJA8; NbExp=3; IntAct=EBI-2823239, EBI-17458373;
CC Q9NUM3; Q96P66: GPR101; NbExp=3; IntAct=EBI-2823239, EBI-17935713;
CC Q9NUM3; Q9BSE4: HERPUD2; NbExp=3; IntAct=EBI-2823239, EBI-2868124;
CC Q9NUM3; P28335: HTR2C; NbExp=3; IntAct=EBI-2823239, EBI-994141;
CC Q9NUM3; Q9UIQ6-2: LNPEP; NbExp=3; IntAct=EBI-2823239, EBI-12133176;
CC Q9NUM3; Q9NQG1: MANBAL; NbExp=3; IntAct=EBI-2823239, EBI-3867271;
CC Q9NUM3; Q5SR56: MFSD14B; NbExp=3; IntAct=EBI-2823239, EBI-373355;
CC Q9NUM3; Q6N075: MFSD5; NbExp=3; IntAct=EBI-2823239, EBI-3920969;
CC Q9NUM3; O14880: MGST3; NbExp=3; IntAct=EBI-2823239, EBI-724754;
CC Q9NUM3; Q99519: NEU1; NbExp=3; IntAct=EBI-2823239, EBI-721517;
CC Q9NUM3; Q5QGT7: RTP2; NbExp=3; IntAct=EBI-2823239, EBI-10244780;
CC Q9NUM3; Q3KNW5: SLC10A6; NbExp=3; IntAct=EBI-2823239, EBI-18159983;
CC Q9NUM3; Q9NP94: SLC39A2; NbExp=3; IntAct=EBI-2823239, EBI-12898013;
CC Q9NUM3; Q6ZP29-3: SLC66A1; NbExp=3; IntAct=EBI-2823239, EBI-12889586;
CC Q9NUM3; P30825: SLC7A1; NbExp=3; IntAct=EBI-2823239, EBI-4289564;
CC Q9NUM3; Q8WWF3: SSMEM1; NbExp=3; IntAct=EBI-2823239, EBI-17280858;
CC Q9NUM3; Q96CE8: TM4SF18; NbExp=3; IntAct=EBI-2823239, EBI-13351685;
CC Q9NUM3; Q9NV12: TMEM140; NbExp=3; IntAct=EBI-2823239, EBI-2844246;
CC Q9NUM3; Q96Q45-2: TMEM237; NbExp=3; IntAct=EBI-2823239, EBI-10982110;
CC Q9NUM3; Q8N661: TMEM86B; NbExp=3; IntAct=EBI-2823239, EBI-2548832;
CC Q9NUM3; P34981: TRHR; NbExp=3; IntAct=EBI-2823239, EBI-18055230;
CC Q9NUM3; Q96GC9: VMP1; NbExp=3; IntAct=EBI-2823239, EBI-2800296;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q9NUM3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9NUM3-2; Sequence=VSP_027302;
CC Name=3;
CC IsoId=Q9NUM3-3; Sequence=VSP_054057, VSP_054058;
CC -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC {ECO:0000305}.
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DR EMBL; AY358687; AAQ89050.1; -; mRNA.
DR EMBL; AK002136; BAA92100.1; -; mRNA.
DR EMBL; AK222547; BAD96267.1; -; mRNA.
DR EMBL; AY780789; AAV98359.1; -; mRNA.
DR EMBL; AL157996; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC047682; AAH47682.1; -; mRNA.
DR EMBL; BC064383; AAH64383.1; -; mRNA.
DR CCDS; CCDS58327.1; -. [Q9NUM3-3]
DR CCDS; CCDS58328.1; -. [Q9NUM3-2]
DR CCDS; CCDS9795.1; -. [Q9NUM3-1]
DR RefSeq; NP_001239077.1; NM_001252148.1. [Q9NUM3-2]
DR RefSeq; NP_001239079.1; NM_001252150.1. [Q9NUM3-3]
DR RefSeq; NP_001239080.1; NM_001252151.1.
DR RefSeq; NP_001239081.1; NM_001252152.1.
DR RefSeq; NP_060845.2; NM_018375.4. [Q9NUM3-1]
DR AlphaFoldDB; Q9NUM3; -.
DR SMR; Q9NUM3; -.
DR BioGRID; 120615; 134.
DR IntAct; Q9NUM3; 82.
DR MINT; Q9NUM3; -.
DR STRING; 9606.ENSP00000336887; -.
DR DrugBank; DB14533; Zinc chloride.
DR DrugBank; DB14548; Zinc sulfate, unspecified form.
DR TCDB; 2.A.5.6.1; the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.
DR GlyGen; Q9NUM3; 2 sites.
DR iPTMnet; Q9NUM3; -.
DR PhosphoSitePlus; Q9NUM3; -.
DR BioMuta; SLC39A9; -.
DR DMDM; 156633628; -.
DR EPD; Q9NUM3; -.
DR jPOST; Q9NUM3; -.
DR MassIVE; Q9NUM3; -.
DR MaxQB; Q9NUM3; -.
DR PaxDb; Q9NUM3; -.
DR PeptideAtlas; Q9NUM3; -.
DR PRIDE; Q9NUM3; -.
DR ProteomicsDB; 33545; -.
DR ProteomicsDB; 82693; -. [Q9NUM3-1]
DR ProteomicsDB; 82694; -. [Q9NUM3-2]
DR TopDownProteomics; Q9NUM3-2; -. [Q9NUM3-2]
DR Antibodypedia; 107; 136 antibodies from 29 providers.
DR DNASU; 55334; -.
DR Ensembl; ENST00000336643.10; ENSP00000336887.5; ENSG00000029364.12. [Q9NUM3-1]
DR Ensembl; ENST00000555840.5; ENSP00000450639.1; ENSG00000029364.12. [Q9NUM3-1]
DR Ensembl; ENST00000556605.5; ENSP00000452385.1; ENSG00000029364.12. [Q9NUM3-3]
DR Ensembl; ENST00000557046.1; ENSP00000451833.1; ENSG00000029364.12. [Q9NUM3-2]
DR GeneID; 55334; -.
DR KEGG; hsa:55334; -.
DR MANE-Select; ENST00000336643.10; ENSP00000336887.5; NM_018375.5; NP_060845.2.
DR UCSC; uc001xle.5; human. [Q9NUM3-1]
DR CTD; 55334; -.
DR DisGeNET; 55334; -.
DR GeneCards; SLC39A9; -.
DR HGNC; HGNC:20182; SLC39A9.
DR HPA; ENSG00000029364; Low tissue specificity.
DR MIM; 619116; gene.
DR neXtProt; NX_Q9NUM3; -.
DR OpenTargets; ENSG00000029364; -.
DR PharmGKB; PA134889179; -.
DR VEuPathDB; HostDB:ENSG00000029364; -.
DR eggNOG; KOG3907; Eukaryota.
DR GeneTree; ENSGT00390000010094; -.
DR InParanoid; Q9NUM3; -.
DR OMA; AAIMIHK; -.
DR PhylomeDB; Q9NUM3; -.
DR TreeFam; TF315051; -.
DR PathwayCommons; Q9NUM3; -.
DR SignaLink; Q9NUM3; -.
DR BioGRID-ORCS; 55334; 47 hits in 1083 CRISPR screens.
DR ChiTaRS; SLC39A9; human.
DR GenomeRNAi; 55334; -.
DR Pharos; Q9NUM3; Tbio.
DR PRO; PR:Q9NUM3; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q9NUM3; protein.
DR Bgee; ENSG00000029364; Expressed in parotid gland and 184 other tissues.
DR ExpressionAtlas; Q9NUM3; baseline and differential.
DR Genevisible; Q9NUM3; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0046873; F:metal ion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006829; P:zinc ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR003689; ZIP.
DR InterPro; IPR045891; ZIP9.
DR PANTHER; PTHR16133; PTHR16133; 1.
DR Pfam; PF02535; Zip; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Glycoprotein; Ion transport; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport; Zinc;
KW Zinc transport.
FT CHAIN 1..307
FT /note="Zinc transporter ZIP9"
FT /id="PRO_0000297597"
FT TRANSMEM 4..24
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 35..55
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 106..126
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 146..166
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 176..196
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 210..230
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 244..264
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 286..306
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 29
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 241
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 135..157
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.3"
FT /id="VSP_027302"
FT VAR_SEQ 232
FT /note="S -> D (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:12975309"
FT /id="VSP_054057"
FT VAR_SEQ 233..307
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:12975309"
FT /id="VSP_054058"
FT VARIANT 64
FT /note="E -> D (in dbSNP:rs2296723)"
FT /id="VAR_034648"
FT VARIANT 221
FT /note="M -> T (in dbSNP:rs2232059)"
FT /evidence="ECO:0000269|Ref.3"
FT /id="VAR_034649"
FT VARIANT 285
FT /note="R -> C (in dbSNP:rs17855898)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_034650"
FT CONFLICT 122
FT /note="V -> M (in Ref. 2; BAD96267)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 307 AA; 32251 MW; 3F2CB0ED7B193183 CRC64;
MDDFISISLL SLAMLVGCYV AGIIPLAVNF SEERLKLVTV LGAGLLCGTA LAVIVPEGVH
ALYEDILEGK HHQASETHNV IASDKAAEKS VVHEHEHSHD HTQLHAYIGV SLVLGFVFML
LVDQIGNSHV HSTDDPEAAR SSNSKITTTL GLVVHAAADG VALGAAASTS QTSVQLIVFV
AIMLHKAPAA FGLVSFLMHA GLERNRIRKH LLVFALAAPV MSMVTYLGLS KSSKEALSEV
NATGVAMLFS AGTFLYVATV HVLPEVGGIG HSHKPDATGG RGLSRLEVAA LVLGCLIPLI
LSVGHQH
