S39A9_MOUSE
ID S39A9_MOUSE Reviewed; 308 AA.
AC Q8BFU1; B2RY14;
DT 21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Zinc transporter ZIP9;
DE AltName: Full=Solute carrier family 39 member 9;
DE AltName: Full=Zrt- and Irt-like protein 9;
DE Short=ZIP-9;
GN Name=Slc39a9; Synonyms=Zip9;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Bone marrow, and Cerebellum;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May act as a zinc-influx transporter. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC {ECO:0000305}.
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DR EMBL; AK080462; BAC37924.1; -; mRNA.
DR EMBL; AK090062; BAC41073.1; -; mRNA.
DR EMBL; BC117754; AAI17755.1; -; mRNA.
DR EMBL; BC117755; AAI17756.1; -; mRNA.
DR EMBL; BC158056; AAI58057.1; -; mRNA.
DR CCDS; CCDS49099.1; -.
DR RefSeq; NP_080520.2; NM_026244.2.
DR RefSeq; XP_017170610.1; XM_017315121.1.
DR AlphaFoldDB; Q8BFU1; -.
DR SMR; Q8BFU1; -.
DR BioGRID; 236547; 2.
DR STRING; 10090.ENSMUSP00000082343; -.
DR GlyGen; Q8BFU1; 2 sites.
DR iPTMnet; Q8BFU1; -.
DR PhosphoSitePlus; Q8BFU1; -.
DR PaxDb; Q8BFU1; -.
DR PRIDE; Q8BFU1; -.
DR ProteomicsDB; 256574; -.
DR Antibodypedia; 107; 136 antibodies from 29 providers.
DR Ensembl; ENSMUST00000085245; ENSMUSP00000082343; ENSMUSG00000048833.
DR GeneID; 328133; -.
DR KEGG; mmu:328133; -.
DR UCSC; uc007obb.2; mouse.
DR CTD; 55334; -.
DR MGI; MGI:1914820; Slc39a9.
DR VEuPathDB; HostDB:ENSMUSG00000048833; -.
DR eggNOG; KOG3907; Eukaryota.
DR GeneTree; ENSGT00390000010094; -.
DR HOGENOM; CLU_028824_1_0_1; -.
DR InParanoid; Q8BFU1; -.
DR OMA; AAIMIHK; -.
DR OrthoDB; 1388694at2759; -.
DR PhylomeDB; Q8BFU1; -.
DR TreeFam; TF315051; -.
DR BioGRID-ORCS; 328133; 4 hits in 74 CRISPR screens.
DR ChiTaRS; Slc39a9; mouse.
DR PRO; PR:Q8BFU1; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; Q8BFU1; protein.
DR Bgee; ENSMUSG00000048833; Expressed in lacrimal gland and 248 other tissues.
DR ExpressionAtlas; Q8BFU1; baseline and differential.
DR Genevisible; Q8BFU1; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0046873; F:metal ion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006829; P:zinc ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR003689; ZIP.
DR InterPro; IPR045891; ZIP9.
DR PANTHER; PTHR16133; PTHR16133; 1.
DR Pfam; PF02535; Zip; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Ion transport; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport; Zinc; Zinc transport.
FT CHAIN 1..308
FT /note="Zinc transporter ZIP9"
FT /id="PRO_0000297599"
FT TRANSMEM 4..24
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 35..55
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 107..127
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 147..167
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 177..197
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 211..231
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 245..265
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 287..307
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 29
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 242
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 308 AA; 32368 MW; ED4615F1593C5182 CRC64;
MDDFLSISLL SVAMLVGCYV AGIIPLAVNF SEERLKLVTV LGAGLLCGTA LAVIVPEGVH
ALYEEVLEGK HHQTSEMKQN GIASDKAAEI SSVHEHEHSH DHTQLHAYIG VSLVLGFVFM
LLVDQIGSSH VHSSDDPETA RPSSSKITTT LGLVVHAAAD GVALGAAAST SQTSVQLIVF
VAIMLHKAPA AFGLVSFLMH AGLERNRIRK HLLVFALAAP AMSMLTYLGL SKSSKEALSE
VNATGVAMLF SAGTFLYVAT VHVLPEVGGM GHSHKPDTTG GRGLSRLEVA ALVLGCLIPL
ILSIGHQH
