ID   S39AA_DANRE             Reviewed;         847 AA.
AC   Q6PEH9;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Zinc transporter ZIP10;
DE   AltName: Full=Solute carrier family 39 member 10;
DE   AltName: Full=Zrt- and Irt-like protein 10;
DE            Short=ZIP-10;
DE   Flags: Precursor;
GN   Name=slc39a10; Synonyms=zip10; ORFNames=zgc:63552;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May act as a zinc-influx transporter. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC       {ECO:0000305}.
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DR   EMBL; BC058056; AAH58056.1; -; mRNA.
DR   RefSeq; NP_956965.1; NM_200671.1.
DR   AlphaFoldDB; Q6PEH9; -.
DR   STRING; 7955.ENSDARP00000035851; -.
DR   PaxDb; Q6PEH9; -.
DR   GeneID; 393644; -.
DR   KEGG; dre:393644; -.
DR   CTD; 57181; -.
DR   ZFIN; ZDB-GENE-040426-1157; slc39a10.
DR   eggNOG; KOG2693; Eukaryota.
DR   InParanoid; Q6PEH9; -.
DR   PhylomeDB; Q6PEH9; -.
DR   PRO; PR:Q6PEH9; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0005385; F:zinc ion transmembrane transporter activity; IDA:ZFIN.
DR   GO; GO:0006882; P:cellular zinc ion homeostasis; IBA:GO_Central.
DR   GO; GO:0055113; P:epiboly involved in gastrulation with mouth forming second; IMP:ZFIN.
DR   GO; GO:0050861; P:positive regulation of B cell receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0010043; P:response to zinc ion; IDA:ZFIN.
DR   GO; GO:0071578; P:zinc ion import across plasma membrane; IBA:GO_Central.
DR   GO; GO:0006829; P:zinc ion transport; IDA:ZFIN.
DR   InterPro; IPR003689; ZIP.
DR   Pfam; PF02535; Zip; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Ion transport; Membrane; Reference proteome; Signal;
KW   Transmembrane; Transmembrane helix; Transport; Zinc; Zinc transport.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   CHAIN           27..847
FT                   /note="Zinc transporter ZIP10"
FT                   /id="PRO_0000297634"
FT   TRANSMEM        447..467
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        474..494
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        529..549
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        705..725
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        750..770
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        779..799
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        817..837
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          136..287
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          299..374
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          613..676
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        157..173
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        189..271
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        343..362
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        634..649
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        650..670
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        385
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   847 AA;  95103 MW;  483CB8E38CC91A23 CRC64;
     MMRVHTHTRL CFLCVLTLLY HQCSHCHEGG SHHHHGHNHG DHDHIHSDLQ ISEMSCNGLS
     DRLVHGSQGE PAENEQRYYI HQLFCRYGQK DRLDFKGFQS LLLSLGLGEV RVVGLEHEEL
     GHDHVAHLDI LEVQDGRHSH SAGHPHSHQN PNISHKTHQH SHHENEEHTL AEDVPCSKTL
     GTGATPPSVS EEHDHDHEHD HDHDKDSDHE HNHRHVTDSP QTQDHEHDHI HLHTHSHKQD
     SDVTQRLELD HDQKSREHAQ EHNDLSDQNH HHHDHHHHKH PHPHLHAPES VVHTTSAMPK
     IQPSVPPELP ANQTRRHRRP SKVKAHRGRN RTSVTVTQAV ELETSGDDHE HSLQDHSPAQ
     QQRGRREVPG SPAHGVLHQH EECLNLTQLL HQYGLSSDSL ISPVQFTYLC PALLYQIDRR
     FCILHYHHVE AEEQVAPSSG WVWMWGFVSI TIISLLSLLG VVLVPILNQS CFKFLLTFLV
     ALAVGTLSGD ALLHLLPHSQ GDHDHNHGEQ MEEEPEVDFL IKFDGVWKGL TALAGIYLLF
     IIEHCIGMFK HYSDQRGGLC HKKKKGEQAK IGRKLSDHKL NRRSDAEWLH LKPLTEGDGT
     TCEAGHNDTQ MTELQPLDSP SKMPLNISDS DHPYEAPVKT EEDNVPKAKS KKHGHGHGHG
     HGHGHGHSHH GHCHSDQEMK DAGIASIAWM VIMGDGMHNF SDGLAIGAAF SANITGGIST
     SVAVFCHELP HELGDFAVLL KAGMSVKQAI VYNLLSALMA YAGMVIGTAV GQYTHNVTSW
     IFAVTAGMFL YVALVDMLPE MLHGDSEEHK RCEMGHFVLQ NFGMLTGFGI MLLIAIFEDH
     IVLDFGF