S39AB_HUMAN
ID S39AB_HUMAN Reviewed; 342 AA.
AC Q8N1S5; B2R8H7; Q8WZ81;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 30-NOV-2010, sequence version 3.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Zinc transporter ZIP11;
DE AltName: Full=Solute carrier family 39 member 11;
DE AltName: Full=Zrt- and Irt-like protein 11;
DE Short=ZIP-11;
GN Name=SLC39A11; Synonyms=C17orf26, ZIP11;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), AND VARIANT ALA-111.
RX PubMed=11707075; DOI=10.1006/geno.2001.6648;
RA Bagheri-Fam S., Ferraz C., Demaille J., Scherer G., Pfeifer D.;
RT "Comparative genomics of the SOX9 region in human and Fugu rubripes:
RT conservation of short regulatory sequence elements within large intergenic
RT regions.";
RL Genomics 78:73-82(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANT
RP ALA-111.
RC TISSUE=Kidney, and Tongue;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT ALA-111.
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT ALA-111.
RC TISSUE=Blood;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Functions as a cellular zinc transporter.
CC {ECO:0000250|UniProtKB:Q8BWY7}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8BWY7};
CC Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8BWY7}. Nucleus
CC {ECO:0000250|UniProtKB:Q8BWY7}. Cytoplasm
CC {ECO:0000250|UniProtKB:Q8BWY7}. Golgi apparatus
CC {ECO:0000250|UniProtKB:Q8BWY7}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8N1S5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8N1S5-2; Sequence=VSP_028976;
CC -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC {ECO:0000305}.
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DR EMBL; AF331643; AAL32175.1; -; mRNA.
DR EMBL; AK095227; BAC04504.1; -; mRNA.
DR EMBL; AK313376; BAG36174.1; -; mRNA.
DR EMBL; AC011120; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC025198; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC080037; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC138336; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471099; EAW89107.1; -; Genomic_DNA.
DR EMBL; BC035631; AAH35631.1; -; mRNA.
DR CCDS; CCDS11690.1; -. [Q8N1S5-2]
DR CCDS; CCDS54160.1; -. [Q8N1S5-1]
DR RefSeq; NP_001153242.1; NM_001159770.1. [Q8N1S5-1]
DR RefSeq; NP_631916.2; NM_139177.3. [Q8N1S5-2]
DR RefSeq; XP_005257191.1; XM_005257134.3.
DR RefSeq; XP_006721817.1; XM_006721754.3.
DR RefSeq; XP_006721818.1; XM_006721755.2. [Q8N1S5-1]
DR RefSeq; XP_011522795.1; XM_011524493.1. [Q8N1S5-1]
DR RefSeq; XP_011522796.1; XM_011524494.2. [Q8N1S5-1]
DR RefSeq; XP_016879819.1; XM_017024330.1. [Q8N1S5-2]
DR RefSeq; XP_016879820.1; XM_017024331.1.
DR RefSeq; XP_016879821.1; XM_017024332.1. [Q8N1S5-2]
DR AlphaFoldDB; Q8N1S5; -.
DR SMR; Q8N1S5; -.
DR BioGRID; 128379; 73.
DR IntAct; Q8N1S5; 26.
DR STRING; 9606.ENSP00000445829; -.
DR DrugBank; DB14533; Zinc chloride.
DR DrugBank; DB14548; Zinc sulfate, unspecified form.
DR TCDB; 2.A.5.5.2; the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.
DR iPTMnet; Q8N1S5; -.
DR PhosphoSitePlus; Q8N1S5; -.
DR BioMuta; SLC39A11; -.
DR DMDM; 313104189; -.
DR EPD; Q8N1S5; -.
DR jPOST; Q8N1S5; -.
DR MassIVE; Q8N1S5; -.
DR MaxQB; Q8N1S5; -.
DR PaxDb; Q8N1S5; -.
DR PeptideAtlas; Q8N1S5; -.
DR PRIDE; Q8N1S5; -.
DR ProteomicsDB; 71629; -. [Q8N1S5-1]
DR ProteomicsDB; 71630; -. [Q8N1S5-2]
DR Antibodypedia; 31896; 122 antibodies from 25 providers.
DR DNASU; 201266; -.
DR Ensembl; ENST00000255559.8; ENSP00000255559.3; ENSG00000133195.12. [Q8N1S5-2]
DR Ensembl; ENST00000542342.6; ENSP00000445829.2; ENSG00000133195.12. [Q8N1S5-1]
DR GeneID; 201266; -.
DR KEGG; hsa:201266; -.
DR MANE-Select; ENST00000255559.8; ENSP00000255559.3; NM_139177.4; NP_631916.2. [Q8N1S5-2]
DR UCSC; uc002jja.4; human. [Q8N1S5-1]
DR CTD; 201266; -.
DR DisGeNET; 201266; -.
DR GeneCards; SLC39A11; -.
DR HGNC; HGNC:14463; SLC39A11.
DR HPA; ENSG00000133195; Low tissue specificity.
DR MIM; 616508; gene.
DR neXtProt; NX_Q8N1S5; -.
DR OpenTargets; ENSG00000133195; -.
DR PharmGKB; PA25581; -.
DR VEuPathDB; HostDB:ENSG00000133195; -.
DR eggNOG; KOG2474; Eukaryota.
DR GeneTree; ENSGT00390000006167; -.
DR HOGENOM; CLU_015114_1_1_1; -.
DR InParanoid; Q8N1S5; -.
DR OMA; MIFVVIE; -.
DR OrthoDB; 892454at2759; -.
DR PhylomeDB; Q8N1S5; -.
DR TreeFam; TF105905; -.
DR PathwayCommons; Q8N1S5; -.
DR SignaLink; Q8N1S5; -.
DR BioGRID-ORCS; 201266; 10 hits in 1075 CRISPR screens.
DR ChiTaRS; SLC39A11; human.
DR GenomeRNAi; 201266; -.
DR Pharos; Q8N1S5; Tbio.
DR PRO; PR:Q8N1S5; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q8N1S5; protein.
DR Bgee; ENSG00000133195; Expressed in bone marrow cell and 171 other tissues.
DR ExpressionAtlas; Q8N1S5; baseline and differential.
DR Genevisible; Q8N1S5; HS.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0005385; F:zinc ion transmembrane transporter activity; ISS:UniProtKB.
DR GO; GO:0071577; P:zinc ion transmembrane transport; IBA:GO_Central.
DR InterPro; IPR003689; ZIP.
DR Pfam; PF02535; Zip; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell membrane; Cytoplasm; Golgi apparatus;
KW Ion transport; Membrane; Nucleus; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport; Zinc; Zinc transport.
FT CHAIN 1..342
FT /note="Zinc transporter ZIP11"
FT /id="PRO_0000308410"
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 44..64
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 72..92
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 194..214
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 263..285
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 290..307
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 322..342
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 144..150
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11707075,
FT ECO:0000303|PubMed:14702039, ECO:0000303|PubMed:15489334"
FT /id="VSP_028976"
FT VARIANT 111
FT /note="T -> A (in dbSNP:rs2466517)"
FT /evidence="ECO:0000269|PubMed:11707075,
FT ECO:0000269|PubMed:14702039, ECO:0000269|PubMed:15489334,
FT ECO:0000269|Ref.4"
FT /id="VAR_036812"
FT CONFLICT 113
FT /note="A -> T (in Ref. 2; BAC04504)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 342 AA; 35396 MW; 89268838281345D5 CRC64;
MLQGHSSVFQ ALLGTFFTWG MTAAGAALVF VFSSGQRRIL DGSLGFAAGV MLAASYWSLL
APAVEMATSS GGFGAFAFFP VAVGFTLGAA FVYLADLLMP HLGAAEDPQT TLALNFGSTL
MKKKSDPEGP ALLFPESELS IRIGRAGLLS DKSENGEAYQ RKKAAATGLP EGPAVPVPSR
GNLAQPGGSS WRRIALLILA ITIHNVPEGL AVGVGFGAIE KTASATFESA RNLAIGIGIQ
NFPEGLAVSL PLRGAGFSTW RAFWYGQLSG MVEPLAGVFG AFAVVLAEPI LPYALAFAAG
AMVYVVMDDI IPEAQISGNG KLASWASILG FVVMMSLDVG LG
