S39AB_MOUSE
ID S39AB_MOUSE Reviewed; 342 AA.
AC Q8BWY7; Q8BZ08; Q8K0E0; Q8VE72; Q99KI2; Q9D8J0;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Zinc transporter ZIP11;
DE AltName: Full=Solute carrier family 39 member 11;
DE AltName: Full=Zrt- and Irt-like protein 11;
DE Short=ZIP-11;
GN Name=Slc39a11; Synonyms=Zip11;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC STRAIN=C57BL/6J, and NOD; TISSUE=Pancreas, and Vagina;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
RC STRAIN=FVB/N; TISSUE=Colon, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney, Liver, and Pancreas;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [5]
RP SUBCELLULAR LOCATION, AND INDUCTION.
RX PubMed=21702047; DOI=10.1002/jcp.22900;
RA Kelleher S.L., Velasquez V., Croxford T.P., McCormick N.H., Lopez V.,
RA MacDavid J.;
RT "Mapping the zinc-transporting system in mammary cells: molecular analysis
RT reveals a phenotype-dependent zinc-transporting network during lactation.";
RL J. Cell. Physiol. 227:1761-1770(2012).
RN [6]
RP SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=24089422; DOI=10.3945/jn.113.184457;
RA Martin A.B., Aydemir T.B., Guthrie G.J., Samuelson D.A., Chang S.M.,
RA Cousins R.J.;
RT "Gastric and colonic zinc transporter ZIP11 (Slc39a11) in mice responds to
RT dietary zinc and exhibits nuclear localization.";
RL J. Nutr. 143:1882-1888(2013).
RN [7]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=23643525; DOI=10.1016/j.jnutbio.2013.02.010;
RA Yu Y., Wu A., Zhang Z., Yan G., Zhang F., Zhang L., Shen X., Hu R.,
RA Zhang Y., Zhang K., Wang F.;
RT "Characterization of the GufA subfamily member SLC39A11/Zip11 as a zinc
RT transporter.";
RL J. Nutr. Biochem. 24:1697-1708(2013).
CC -!- FUNCTION: Functions as a cellular zinc transporter.
CC {ECO:0000269|PubMed:23643525}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:24089422};
CC Multi-pass membrane protein {ECO:0000305}. Nucleus
CC {ECO:0000269|PubMed:24089422}. Cytoplasm {ECO:0000269|PubMed:24089422}.
CC Golgi apparatus {ECO:0000269|PubMed:21702047}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8BWY7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8BWY7-2; Sequence=VSP_028977, VSP_028978;
CC Name=3;
CC IsoId=Q8BWY7-3; Sequence=VSP_028978;
CC -!- TISSUE SPECIFICITY: Highly expressed in the testes and portions of the
CC digestive system including the stomach, ileum and cecum. In contrast,
CC expressed at very low levels in liver, duodenum, jejunum, and colon.
CC {ECO:0000269|PubMed:23643525, ECO:0000269|PubMed:24089422}.
CC -!- INDUCTION: Up-regulated during lactation.
CC {ECO:0000269|PubMed:21702047}.
CC -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH04643.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAH04643.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305};
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DR EMBL; AK007986; BAB25390.1; -; mRNA.
DR EMBL; AK036999; BAC29664.1; -; mRNA.
DR EMBL; AK049368; BAC33713.1; -; mRNA.
DR EMBL; AK170673; BAE41950.1; -; mRNA.
DR EMBL; AL596104; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL603705; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL604025; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC004643; AAH04643.1; ALT_INIT; mRNA.
DR EMBL; BC019647; AAH19647.1; -; mRNA.
DR EMBL; BC031751; AAH31751.1; -; mRNA.
DR CCDS; CCDS36363.1; -. [Q8BWY7-3]
DR CCDS; CCDS48975.1; -. [Q8BWY7-1]
DR CCDS; CCDS88280.1; -. [Q8BWY7-2]
DR RefSeq; NP_001159975.1; NM_001166503.1. [Q8BWY7-1]
DR RefSeq; NP_081492.4; NM_027216.5. [Q8BWY7-3]
DR RefSeq; XP_006534190.1; XM_006534127.3.
DR RefSeq; XP_006534193.1; XM_006534130.3. [Q8BWY7-1]
DR RefSeq; XP_006534197.1; XM_006534134.3.
DR RefSeq; XP_011247533.1; XM_011249231.1. [Q8BWY7-1]
DR RefSeq; XP_011247534.1; XM_011249232.1.
DR RefSeq; XP_017170232.1; XM_017314743.1.
DR AlphaFoldDB; Q8BWY7; -.
DR SMR; Q8BWY7; -.
DR IntAct; Q8BWY7; 1.
DR MINT; Q8BWY7; -.
DR STRING; 10090.ENSMUSP00000102244; -.
DR iPTMnet; Q8BWY7; -.
DR PhosphoSitePlus; Q8BWY7; -.
DR EPD; Q8BWY7; -.
DR MaxQB; Q8BWY7; -.
DR PaxDb; Q8BWY7; -.
DR PRIDE; Q8BWY7; -.
DR ProteomicsDB; 260787; -. [Q8BWY7-1]
DR ProteomicsDB; 260788; -. [Q8BWY7-2]
DR ProteomicsDB; 260789; -. [Q8BWY7-3]
DR Antibodypedia; 31896; 122 antibodies from 25 providers.
DR DNASU; 69806; -.
DR Ensembl; ENSMUST00000042657; ENSMUSP00000037331; ENSMUSG00000041654. [Q8BWY7-2]
DR Ensembl; ENSMUST00000071539; ENSMUSP00000071469; ENSMUSG00000041654. [Q8BWY7-3]
DR Ensembl; ENSMUST00000106633; ENSMUSP00000102244; ENSMUSG00000041654. [Q8BWY7-1]
DR GeneID; 69806; -.
DR KEGG; mmu:69806; -.
DR UCSC; uc007mem.2; mouse. [Q8BWY7-3]
DR UCSC; uc007men.2; mouse. [Q8BWY7-1]
DR CTD; 201266; -.
DR MGI; MGI:1917056; Slc39a11.
DR VEuPathDB; HostDB:ENSMUSG00000041654; -.
DR eggNOG; KOG2474; Eukaryota.
DR GeneTree; ENSGT00390000006167; -.
DR HOGENOM; CLU_015114_1_1_1; -.
DR InParanoid; Q8BWY7; -.
DR OMA; MIFVVIE; -.
DR OrthoDB; 892454at2759; -.
DR PhylomeDB; Q8BWY7; -.
DR TreeFam; TF105905; -.
DR BioGRID-ORCS; 69806; 4 hits in 74 CRISPR screens.
DR ChiTaRS; Slc39a11; mouse.
DR PRO; PR:Q8BWY7; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q8BWY7; protein.
DR Bgee; ENSMUSG00000041654; Expressed in epithelium of stomach and 227 other tissues.
DR ExpressionAtlas; Q8BWY7; baseline and differential.
DR Genevisible; Q8BWY7; MM.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR GO; GO:0005385; F:zinc ion transmembrane transporter activity; IDA:UniProtKB.
DR GO; GO:0071577; P:zinc ion transmembrane transport; IBA:GO_Central.
DR InterPro; IPR003689; ZIP.
DR Pfam; PF02535; Zip; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell membrane; Cytoplasm; Golgi apparatus;
KW Ion transport; Membrane; Nucleus; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport; Zinc; Zinc transport.
FT CHAIN 1..342
FT /note="Zinc transporter ZIP11"
FT /id="PRO_0000308411"
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 44..64
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 72..92
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 194..214
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 263..285
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 290..307
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 322..342
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 102
FT /note="L -> LLQVSFLPSGDCKMPTATKTPLLGRTRAVELLGGNQ (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_028977"
FT VAR_SEQ 144..150
FT /note="Missing (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_028978"
FT CONFLICT 22
FT /note="T -> S (in Ref. 3; AAH19647)"
FT /evidence="ECO:0000305"
FT CONFLICT 49
FT /note="G -> V (in Ref. 1; BAC29664)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 342 AA; 35466 MW; 3A5F4517D0D5652D CRC64;
MLQGYSSVVQ ALLGTFFTWA MTAAGAALVF IFSSGQRRIL DGSLGFAAGV MLAASYWSLL
APAVEMATSS GGFGAFAFFP VAVGFTLGAA FVYLADLLMP HLGATEDPQT ALALNLDPAL
MKKSDPRDPT SLLFPESELS IRIGSTGLLS DKRENGEVYQ RKKVAATDLA EGVAPSGSMH
GSSGQPGGSS WRRIALLILA ITIHNIPEGL AVGVGFGAVE KTASATFESA RNLAIGIGIQ
NFPEGLAVSL PLRGAGFSTW KAFWYGQLSG MVEPLAGVFG AFAVVLAEPI LPYALAFAAG
AMVYVVMDDI IPEAQISGNG KLASWASILG FVVMMSLDVG LG
