ID   S39AB_RAT               Reviewed;         335 AA.
AC   Q6P6S2;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Zinc transporter ZIP11;
DE   AltName: Full=Solute carrier family 39 member 11;
DE   AltName: Full=Zrt- and Irt-like protein 11;
DE            Short=ZIP-11;
GN   Name=Slc39a11; Synonyms=Zip11;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Prostate;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Functions as a cellular zinc transporter.
CC       {ECO:0000250|UniProtKB:Q8BWY7}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8BWY7};
CC       Multi-pass membrane protein {ECO:0000305}. Nucleus
CC       {ECO:0000250|UniProtKB:Q8BWY7}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q8BWY7}. Golgi apparatus
CC       {ECO:0000250|UniProtKB:Q8BWY7}.
CC   -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC       {ECO:0000305}.
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DR   EMBL; BC062054; AAH62054.1; -; mRNA.
DR   RefSeq; NP_001013060.1; NM_001013042.1.
DR   AlphaFoldDB; Q6P6S2; -.
DR   SMR; Q6P6S2; -.
DR   STRING; 10116.ENSRNOP00000039028; -.
DR   PaxDb; Q6P6S2; -.
DR   Ensembl; ENSRNOT00000097833; ENSRNOP00000091972; ENSRNOG00000031213.
DR   GeneID; 287796; -.
DR   KEGG; rno:287796; -.
DR   CTD; 201266; -.
DR   RGD; 1311981; Slc39a11.
DR   eggNOG; KOG2474; Eukaryota.
DR   GeneTree; ENSGT00390000006167; -.
DR   HOGENOM; CLU_015114_1_1_1; -.
DR   InParanoid; Q6P6S2; -.
DR   OMA; MIFVVIE; -.
DR   OrthoDB; 892454at2759; -.
DR   PhylomeDB; Q6P6S2; -.
DR   PRO; PR:Q6P6S2; -.
DR   Proteomes; UP000002494; Chromosome 10.
DR   Bgee; ENSRNOG00000031213; Expressed in pancreas and 20 other tissues.
DR   Genevisible; Q6P6S2; RN.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0005385; F:zinc ion transmembrane transporter activity; ISS:UniProtKB.
DR   GO; GO:0071577; P:zinc ion transmembrane transport; IBA:GO_Central.
DR   InterPro; IPR003689; ZIP.
DR   Pfam; PF02535; Zip; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cytoplasm; Golgi apparatus; Ion transport; Membrane;
KW   Nucleus; Reference proteome; Transmembrane; Transmembrane helix; Transport;
KW   Zinc; Zinc transport.
FT   CHAIN           1..335
FT                   /note="Zinc transporter ZIP11"
FT                   /id="PRO_0000308412"
FT   TRANSMEM        12..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        44..64
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        72..92
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        187..207
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        256..278
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        283..300
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        315..335
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   335 AA;  34868 MW;  641975960723C277 CRC64;
     MLQGYSSVSQ ALLGTFFTWA MTAAGAALVF IFSSGQRRIL DGSLGFAAGV MLAASYWSLL
     APAVEMATSS GGFGAFAFFP VAVGFTLGAA FVYLADLLMP HLGAGEDPQT ALALNLDPAL
     VKKSDLKDPA SLLFPERELS IRIDKRENGE VYQRKKLAAT DFPEGAAPSG PVHGNSGQPG
     VSSWRRIALL ILAITIHNIP EGLAVGVGFG AVEKTASATF ESARNLAIGI GIQNFPEGLA
     VSLPLRGAGF STWKAFWYGQ LSGMVEPLAG VFGAFAVVLA EPVLPYALAF AAGAMVYVVM
     DDIIPEAQIS GNGKLASWAS ILGFVVMMSL DVGLG