ID   S39AB_XENTR             Reviewed;         336 AA.
AC   Q28J44;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=Zinc transporter ZIP11;
DE   AltName: Full=Solute carrier family 39 member 11;
DE   AltName: Full=Zrt- and Irt-like protein 11;
DE            Short=ZIP-11;
GN   Name=slc39a11; Synonyms=zip11; ORFNames=TNeu027c15.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Neurula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Functions as a cellular zinc transporter.
CC       {ECO:0000250|UniProtKB:Q8BWY7}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8BWY7};
CC       Multi-pass membrane protein {ECO:0000305}. Nucleus
CC       {ECO:0000250|UniProtKB:Q8BWY7}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q8BWY7}. Golgi apparatus
CC       {ECO:0000250|UniProtKB:Q8BWY7}.
CC   -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC       {ECO:0000305}.
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DR   EMBL; CR760068; CAJ83369.1; -; mRNA.
DR   RefSeq; NP_001016721.1; NM_001016721.2.
DR   AlphaFoldDB; Q28J44; -.
DR   SMR; Q28J44; -.
DR   PaxDb; Q28J44; -.
DR   GeneID; 549475; -.
DR   KEGG; xtr:549475; -.
DR   CTD; 201266; -.
DR   Xenbase; XB-GENE-1003667; slc39a11.
DR   eggNOG; KOG2474; Eukaryota.
DR   InParanoid; Q28J44; -.
DR   OrthoDB; 892454at2759; -.
DR   Proteomes; UP000008143; Chromosome 10.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000009976; Expressed in 4-cell stage embryo and 12 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0005385; F:zinc ion transmembrane transporter activity; ISS:UniProtKB.
DR   GO; GO:0071577; P:zinc ion transmembrane transport; IBA:GO_Central.
DR   InterPro; IPR003689; ZIP.
DR   Pfam; PF02535; Zip; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cytoplasm; Golgi apparatus; Ion transport; Membrane;
KW   Nucleus; Reference proteome; Transmembrane; Transmembrane helix; Transport;
KW   Zinc; Zinc transport.
FT   CHAIN           1..336
FT                   /note="Zinc transporter ZIP11"
FT                   /id="PRO_0000308413"
FT   TRANSMEM        12..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        44..64
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        75..95
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        188..208
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        258..278
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        280..300
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        316..336
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   336 AA;  35522 MW;  A415C5384C0BE2C7 CRC64;
     MIDGYSPVLQ SLLGTLLTWG LTAAGSALVF IFSSGQRQIL DGSLGFAAGV MLAASYWSLL
     APAIEMAENS NQYGSFAFVP AAVGFLVGAG FVYLADQLMP ALGFSEDPYS IATLNQDSKP
     IKEKDEGDLY EDKELSIRIG RGGFHQDKIE NGDVYQRKRG TVSPLAEDFS MLNPREAAHK
     GGSSWRRIML LILAITIHNI PEGLAVGVGF GAIGKTPSAT FENARNLALG IGIQNFPEGL
     AVSLPLRGAG VSTWKAFWYG QLSGMVEPIA GLLGTIAISL AEPLLPYALA FAAGAMVYVV
     TDDIIPEAQA CGNGKLASWT CIFGFIVMMS LDVGLG