S39AC_BOVIN
ID S39AC_BOVIN Reviewed; 654 AA.
AC Q08E40;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 31-OCT-2006, sequence version 1.
DT 03-AUG-2022, entry version 88.
DE RecName: Full=Zinc transporter ZIP12;
DE AltName: Full=Solute carrier family 39 member 12;
DE AltName: Full=Zrt- and Irt-like protein 12;
DE Short=ZIP-12;
GN Name=SLC39A12; Synonyms=ZIP12;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Thalamus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Acts as a zinc-influx transporter. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC {ECO:0000305}.
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DR EMBL; BC123434; AAI23435.1; -; mRNA.
DR RefSeq; NP_001070346.1; NM_001076878.1.
DR RefSeq; XP_010809425.1; XM_010811123.2.
DR RefSeq; XP_010809426.1; XM_010811124.2.
DR AlphaFoldDB; Q08E40; -.
DR SMR; Q08E40; -.
DR STRING; 9913.ENSBTAP00000020631; -.
DR PaxDb; Q08E40; -.
DR Ensembl; ENSBTAT00000020631; ENSBTAP00000020631; ENSBTAG00000015525.
DR GeneID; 527210; -.
DR KEGG; bta:527210; -.
DR CTD; 221074; -.
DR VEuPathDB; HostDB:ENSBTAG00000015525; -.
DR VGNC; VGNC:34860; SLC39A12.
DR eggNOG; KOG2693; Eukaryota.
DR GeneTree; ENSGT00940000157914; -.
DR HOGENOM; CLU_015114_12_1_1; -.
DR InParanoid; Q08E40; -.
DR OMA; AQVCFSA; -.
DR OrthoDB; 657777at2759; -.
DR TreeFam; TF318470; -.
DR Proteomes; UP000009136; Chromosome 13.
DR ExpressionAtlas; Q08E40; baseline.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR GO; GO:0005385; F:zinc ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0006882; P:cellular zinc ion homeostasis; IBA:GO_Central.
DR GO; GO:0031113; P:regulation of microtubule polymerization; IEA:Ensembl.
DR GO; GO:0010975; P:regulation of neuron projection development; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IEA:Ensembl.
DR GO; GO:0071578; P:zinc ion import across plasma membrane; IBA:GO_Central.
DR InterPro; IPR003689; ZIP.
DR InterPro; IPR041137; ZIP4_N.
DR Pfam; PF02535; Zip; 2.
DR Pfam; PF18292; ZIP4_domain; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Ion transport; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport; Zinc; Zinc transport.
FT CHAIN 1..654
FT /note="Zinc transporter ZIP12"
FT /id="PRO_0000312496"
FT TOPO_DOM 1..202
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 203..223
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 224..369
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 370..390
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 391..398
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 399..419
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 420..448
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 449..469
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 470..501
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 502..522
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 523..563
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 564..584
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 585..594
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 595..615
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 616..626
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 627..647
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 648..654
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT MOTIF 543..548
FT /note="XEXPHE-motif"
FT CARBOHYD 59
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 162
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 654 AA; 72783 MW; FFE3DE5115AF6B5E CRC64;
MCFWTKPSVS WVSLFLLLSL DPSTETEKPS TQDSSSTWSP GQLTEVLRVL SADDPRPLNH
SRSLIRTLLE KTGCPRRTDG RQGDCNLCFE PDALLLIAGG DFEDQLKEEV IQRVSLLLLY
YIIHQEEICS SKLNMSNKEY TFYLHSLLSL RQDEDSYFLS QNETEDILAF TRQYFDTSRN
QCMETKVLQK KSGILSSDGA DENTLPQLAA TIIALSLQGV CLGQRNLPPP DYFTEYIFSA
LNSTNTLHLS ELDKLLNTLW TKSTCIRKDK IHQLRRKQNS LTLHDGDYSN LSVSMDPESE
DGPISWDQTC FSAGQLVNIF LQNKLSPISK EDFKQMSPGI IQQLLSCSCQ LPQNQQAKIA
PTTLEKYGYS TVAVTLLTLG SMLGTTLILF HSCEENYRLI LQLFVGLAVG TLSGDALLHL
IPQILGLHMQ ETSEFGHFYE NKGHIWKLLG LIGGIHGFFL IEKCFTLLVS PGAKKGPEDA
QAAEIPIPSV NTPNRKCKTI SLLAIMILVG DSLHNFADGL VIGAAFSSSS EAGVTTTIAI
LCHEIPHEMG DFAVLLSSGL PVKIAILMNF ISALTAFIGL YIGLSVSTDP CIQNWILTVT
AGMFLYLSLV EMLPEMTHVQ TQRPWLMFLL QNFGLTLGWL SLFLLAIYEQ NIKI
