ID   S39AC_MACFA             Reviewed;         654 AA.
AC   Q95KA5;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 55.
DE   RecName: Full=Zinc transporter ZIP12;
DE   AltName: Full=Solute carrier family 39 member 12;
DE   AltName: Full=Zrt- and Irt-like protein 12;
DE            Short=ZIP-12;
GN   Name=SLC39A12; Synonyms=ZIP12; ORFNames=QmoA-11613;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Medulla oblongata;
RA   Osada N., Hida M., Kusuda J., Tanuma R., Iseki K., Hirai M., Terao K.,
RA   Suzuki Y., Sugano S., Hashimoto K.;
RT   "Isolation of full-length cDNA clones from macaque brain cDNA libraries.";
RL   Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a zinc-influx transporter. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC       {ECO:0000305}.
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DR   EMBL; AB063029; BAB60771.1; -; mRNA.
DR   RefSeq; NP_001306521.1; NM_001319592.1.
DR   AlphaFoldDB; Q95KA5; -.
DR   SMR; Q95KA5; -.
DR   STRING; 9541.XP_005564801.1; -.
DR   GeneID; 102129902; -.
DR   CTD; 221074; -.
DR   eggNOG; KOG2693; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0046873; F:metal ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006829; P:zinc ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR003689; ZIP.
DR   InterPro; IPR041137; ZIP4_N.
DR   Pfam; PF02535; Zip; 2.
DR   Pfam; PF18292; ZIP4_domain; 1.
PE   2: Evidence at transcript level;
KW   Ion transport; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport; Zinc; Zinc transport.
FT   CHAIN           1..654
FT                   /note="Zinc transporter ZIP12"
FT                   /id="PRO_0000312498"
FT   TOPO_DOM        1..207
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        208..228
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        229..369
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        370..390
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        391..398
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        399..419
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        420..448
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        449..469
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        470..501
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        502..522
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        523..565
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        566..586
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        587..589
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        590..610
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        611..626
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        627..647
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        648..654
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   MOTIF           543..548
FT                   /note="XEXPHE-motif"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   654 AA;  72794 MW;  99E4D4893FFB4CBC CRC64;
     MCFQTKLSIS WVPLFLLLSR VFSTETDKPS AQDSRGRGSS GQLADLLQVL SAGDHPPHNH
     SRSLIKTLLE KTGCPRRRNG MQGDCHLCFE PDALLLIAGG NFEDQLREEV VQRVSLLLLY
     YIIHQEEICS SKLNMSNKEY KFYLHSLLSL RQDEDSSFLS QNETEDILAF TRQYFDTSQS
     QCMETKTLQK KSGIVSSEGA NENTLPQLAA TIITLSLQGV CLGQGNLPSP DYFTEYIFSS
     LNRTHTLRLS ELDQLLNTLW TRSTCIKKDK IHQLQRKQNS IITPDQDYSN FSSSMDEESE
     DGPISWDQTC FSARQLVEIF LQKSLSPISK EDFKQMSPGI IQQLLSCSCH LPKDQQAKLP
     PTTLEKYGYS TVAVTLLTLG SMLGTALVLF HSCEENYRLI LQLFVGLAVG TLSGDALLHL
     IPQVLGLHKQ EAPEFGHFHE SKGHIWKLLG LIGGIHGFFL IEKCFILLVS PNDKKSPEDS
     QAAEMPIGSM TAPNRKCKVI SLLAIMILVG DSLHNFADGL AIGAAFSSSS ESGVTTTIAI
     LCHEIPHEMG DFAVLLSSGL SMKTAILMNF ISSLTAFIGL YIGLSVSADP CVQDWIFTVT
     AGMFLYLSLV EMPPEMTHVQ TQRPWMMFLL QNFGLILGWL SLLLLAIYEQ NIKK