S39AC_MOUSE
ID S39AC_MOUSE Reviewed; 689 AA.
AC Q5FWH7; A2AQ76;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Zinc transporter ZIP12;
DE AltName: Full=Solute carrier family 39 member 12;
DE AltName: Full=Zrt- and Irt-like protein 12;
DE Short=ZIP-12;
GN Name=Slc39a12; Synonyms=Zip12;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Acts as a zinc-influx transporter. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5FWH7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5FWH7-2; Sequence=VSP_029851;
CC -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAM22554.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AL844558; CAM22554.1; ALT_INIT; Genomic_DNA.
DR EMBL; BC089362; AAH89362.1; -; mRNA.
DR EMBL; BC113764; AAI13765.1; -; mRNA.
DR EMBL; BC113765; AAI13766.1; -; mRNA.
DR CCDS; CCDS15701.1; -. [Q5FWH7-1]
DR RefSeq; NP_001012305.1; NM_001012305.2. [Q5FWH7-1]
DR AlphaFoldDB; Q5FWH7; -.
DR SMR; Q5FWH7; -.
DR STRING; 10090.ENSMUSP00000080911; -.
DR GlyConnect; 2831; 1 N-Linked glycan (1 site).
DR GlyGen; Q5FWH7; 3 sites, 1 N-linked glycan (1 site).
DR iPTMnet; Q5FWH7; -.
DR PhosphoSitePlus; Q5FWH7; -.
DR MaxQB; Q5FWH7; -.
DR PaxDb; Q5FWH7; -.
DR PeptideAtlas; Q5FWH7; -.
DR PRIDE; Q5FWH7; -.
DR ProteomicsDB; 256900; -. [Q5FWH7-1]
DR ProteomicsDB; 256901; -. [Q5FWH7-2]
DR Antibodypedia; 12047; 58 antibodies from 21 providers.
DR DNASU; 277468; -.
DR Ensembl; ENSMUST00000082290; ENSMUSP00000080911; ENSMUSG00000036949. [Q5FWH7-1]
DR Ensembl; ENSMUST00000114731; ENSMUSP00000110379; ENSMUSG00000036949. [Q5FWH7-2]
DR GeneID; 277468; -.
DR KEGG; mmu:277468; -.
DR UCSC; uc008ikl.2; mouse. [Q5FWH7-1]
DR CTD; 221074; -.
DR MGI; MGI:2139274; Slc39a12.
DR VEuPathDB; HostDB:ENSMUSG00000036949; -.
DR eggNOG; KOG2693; Eukaryota.
DR GeneTree; ENSGT00940000157914; -.
DR HOGENOM; CLU_015114_12_1_1; -.
DR InParanoid; Q5FWH7; -.
DR OMA; AQVCFSA; -.
DR OrthoDB; 657777at2759; -.
DR PhylomeDB; Q5FWH7; -.
DR TreeFam; TF318470; -.
DR BioGRID-ORCS; 277468; 1 hit in 71 CRISPR screens.
DR ChiTaRS; Slc39a12; mouse.
DR PRO; PR:Q5FWH7; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q5FWH7; protein.
DR Bgee; ENSMUSG00000036949; Expressed in choroid plexus epithelium and 89 other tissues.
DR ExpressionAtlas; Q5FWH7; baseline and differential.
DR Genevisible; Q5FWH7; MM.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IDA:MGI.
DR GO; GO:0005886; C:plasma membrane; IDA:MGI.
DR GO; GO:0005385; F:zinc ion transmembrane transporter activity; IDA:MGI.
DR GO; GO:0006882; P:cellular zinc ion homeostasis; IBA:GO_Central.
DR GO; GO:1903672; P:positive regulation of sprouting angiogenesis; ISO:MGI.
DR GO; GO:0031113; P:regulation of microtubule polymerization; IMP:MGI.
DR GO; GO:0010975; P:regulation of neuron projection development; IMP:MGI.
DR GO; GO:0036293; P:response to decreased oxygen levels; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IDA:MGI.
DR GO; GO:0071578; P:zinc ion import across plasma membrane; IDA:MGI.
DR InterPro; IPR003689; ZIP.
DR InterPro; IPR041137; ZIP4_N.
DR Pfam; PF02535; Zip; 1.
DR Pfam; PF18292; ZIP4_domain; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Glycoprotein; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..689
FT /note="Zinc transporter ZIP12"
FT /id="PRO_0000312499"
FT TOPO_DOM 1..201
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 202..222
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 223..369
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 370..390
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 391..397
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 398..418
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 419..447
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 448..468
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 469..536
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 537..557
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 558..600
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 601..621
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 622..629
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 630..650
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 651..662
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 663..683
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 684..689
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT REGION 275..303
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 578..583
FT /note="XEXPHE-motif"
FT /evidence="ECO:0000250"
FT CARBOHYD 6
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 133
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 474..509
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_029851"
SQ SEQUENCE 689 AA; 76215 MW; 9DA3FB51682147C2 CRC64;
MCFWTNLSVW MILLSHSLSL VSSTETGKTL TQNNSRAGSQ GLLEVLRVLS AGDHWSLNHP
QSLIKILLER TGCPQRTDWT QGDCKLCLEA DALLLTAGGN LEDELREEVV QRVSLLLLYY
IIHQEEICSS KLNMSNREYE FYLHSLLGLR QDEDSYFLSE KETDDILAFT RKYFGTSSSQ
CMETKILQRE SGIQGSNGAD EKTLPQLAAT IIALSLQGVC LGRKALPSPD DFTEYIFSFL
NSTNTLHLSE IEQLLNMLTT RRTCAKEDKY LHQYQRKQNT EEHSLRDPKT STAMDKESDD
HSPSWDQACF SARQLVEIFL QNHSSLSISK EDFKQLSPGI IQQLLSCSCQ MPKDQQAKPP
PTTLEKYGYS TVAVTLLTLG SMLGTALVLF HSCEENYSLI LQLFVGLAVG TLSGDALLHL
IPQVLGLHKQ EAEFGHFHES QSPIWKLLGL LGGIHGFFLI EKCFILLVSP NTKGLPLVNE
HVGHTHHLGL NPELNDQSSG GKSISTIQLK GPEDSQTTVL PIGNVPASNR NGKTISLLAI
MILVGDSLHN FADGLVIGTA FSSSLESGVT TTIAILCHEI PHEMGDFAVL LSSGLSVRTA
ILMNFLSALT AFAGLYIGLS VSADPRVQDW ILTVTAGMFL YLSLVGMLPE MTHVQTQRPW
MTFLLQNVGL VLGWFSLLLL AVYEQNIKI
