ID   S39AD_BOVIN             Reviewed;         423 AA.
AC   A5D7H1;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Zinc transporter ZIP13;
DE   AltName: Full=Solute carrier family 39 member 13;
DE   AltName: Full=Zrt- and Irt-like protein 13;
DE            Short=ZIP-13;
GN   Name=SLC39A13; Synonyms=ZIP13;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal skin;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a zinc-influx transporter. {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-
CC       pass membrane protein.
CC   -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC       {ECO:0000305}.
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DR   EMBL; BC140552; AAI40553.1; -; mRNA.
DR   RefSeq; NP_001091601.1; NM_001098132.1.
DR   AlphaFoldDB; A5D7H1; -.
DR   SMR; A5D7H1; -.
DR   STRING; 9913.ENSBTAP00000047569; -.
DR   PaxDb; A5D7H1; -.
DR   PRIDE; A5D7H1; -.
DR   GeneID; 614946; -.
DR   KEGG; bta:614946; -.
DR   CTD; 91252; -.
DR   eggNOG; KOG2694; Eukaryota.
DR   HOGENOM; CLU_015114_0_2_1; -.
DR   InParanoid; A5D7H1; -.
DR   OrthoDB; 657777at2759; -.
DR   TreeFam; TF318470; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005385; F:zinc ion transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0006882; P:cellular zinc ion homeostasis; IBA:GO_Central.
DR   GO; GO:0071577; P:zinc ion transmembrane transport; IBA:GO_Central.
DR   InterPro; IPR003689; ZIP.
DR   Pfam; PF02535; Zip; 3.
PE   2: Evidence at transcript level;
KW   Golgi apparatus; Ion transport; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport; Zinc; Zinc transport.
FT   CHAIN           1..423
FT                   /note="Zinc transporter ZIP13"
FT                   /id="PRO_0000312308"
FT   TOPO_DOM        1..15
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        16..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        37..68
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        69..89
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        90..108
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        109..129
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        130..149
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        150..170
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        171..235
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        236..256
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        257..278
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        279..299
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        300..368
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        369..389
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        390..401
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        402..422
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        423
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   MOTIF           257..262
FT                   /note="XEXPHE-motif"
SQ   SEQUENCE   423 AA;  44432 MW;  7438842BC198F756 CRC64;
     MPGCPCPGIG MAGQRLLFLA ALALELLGGA GGSQQALRSR GVAAACRLDS KESESWGALL
     SGERLETWIC SLLGSLMVGL SGVFPLLVIP LEMGTTLRSE AGARRLKQLL SFALGGLLGN
     VFLHLLPEAW AYTNSASSGG ERQSLQQQQQ LGLWVIAGFL TFLVLEKLFF DSKGKEETSQ
     APSKDPAAAA ALNGGHYLAQ PAAEPGPSAV VRNIKVSGYL NLLANTIDNF THGLAVAASF
     LVSKKIGLLT TMAILLHEIP HEVGDFAILL RAGFDRWSAA KLQLSTALGG LLGACFAICA
     QSPKGVGTGV GVVAVRRGAL AEGHGRPDPG IRARLCSGPP RGMGGGRYTW PPSPPQPVRA
     PPPATEETVA WILPFTSGGF LYIALVNVLP DLLEEDDPWR SLQQVLLLCA GIVVMVLFSV
     FVE