S39AD_CHICK
ID S39AD_CHICK Reviewed; 366 AA.
AC Q5ZI20;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Zinc transporter ZIP13;
DE AltName: Full=Solute carrier family 39 member 13;
DE AltName: Full=Zrt- and Irt-like protein 13;
DE Short=ZIP-13;
GN Name=SLC39A13; Synonyms=ZIP13; ORFNames=RCJMB04_31f18;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB; TISSUE=Bursa of Fabricius;
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
CC -!- FUNCTION: Acts as a zinc-influx transporter. {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-
CC pass membrane protein.
CC -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC {ECO:0000305}.
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DR EMBL; AJ720964; CAG32623.1; -; mRNA.
DR RefSeq; NP_001008471.1; NM_001008471.1.
DR RefSeq; XP_015142500.1; XM_015287014.1.
DR RefSeq; XP_015142501.1; XM_015287015.1.
DR RefSeq; XP_015142502.1; XM_015287016.1.
DR AlphaFoldDB; Q5ZI20; -.
DR SMR; Q5ZI20; -.
DR STRING; 9031.ENSGALP00000013168; -.
DR PaxDb; Q5ZI20; -.
DR Ensembl; ENSGALT00000013183; ENSGALP00000013168; ENSGALG00000008122.
DR Ensembl; ENSGALT00000097929; ENSGALP00000067537; ENSGALG00000008122.
DR Ensembl; ENSGALT00000106651; ENSGALP00000073525; ENSGALG00000008122.
DR Ensembl; ENSGALT00000108362; ENSGALP00000071744; ENSGALG00000008122.
DR GeneID; 423183; -.
DR KEGG; gga:423183; -.
DR CTD; 91252; -.
DR VEuPathDB; HostDB:geneid_423183; -.
DR eggNOG; KOG2694; Eukaryota.
DR GeneTree; ENSGT00940000157349; -.
DR HOGENOM; CLU_015114_0_2_1; -.
DR InParanoid; Q5ZI20; -.
DR OMA; TGDSVHC; -.
DR OrthoDB; 657777at2759; -.
DR PhylomeDB; Q5ZI20; -.
DR TreeFam; TF318470; -.
DR PRO; PR:Q5ZI20; -.
DR Proteomes; UP000000539; Chromosome 5.
DR Bgee; ENSGALG00000008122; Expressed in heart and 13 other tissues.
DR ExpressionAtlas; Q5ZI20; baseline and differential.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005385; F:zinc ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0006882; P:cellular zinc ion homeostasis; IBA:GO_Central.
DR GO; GO:0071577; P:zinc ion transmembrane transport; IBA:GO_Central.
DR InterPro; IPR003689; ZIP.
DR Pfam; PF02535; Zip; 1.
PE 2: Evidence at transcript level;
KW Golgi apparatus; Ion transport; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport; Zinc; Zinc transport.
FT CHAIN 1..366
FT /note="Zinc transporter ZIP13"
FT /id="PRO_0000312313"
FT TOPO_DOM 1..5
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 6..26
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 27..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..78
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 79..97
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..137
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..158
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..225
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 226..246
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 247..282
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 283..303
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 304..313
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 314..334
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 335..343
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 344..364
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 365..366
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT REGION 183..205
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 261..266
FT /note="XEXPHE-motif"
SQ SEQUENCE 366 AA; 39274 MW; 2477ABDFA2E90909 CRC64;
MTKQKLLLNG TFSLILIVAC EAQQLPRSHA ASSSGPLCEK EAESWGNLLS SERLDAWICS
LIGSFMVGLS GIFPLLVIPF ETGAALRSEA GSRRLKQLLS FAIGGLLGNV FLHLLPEAWA
YTCSAAAGEG QSFQQQKLLG LWVIIGFLTF LALEKIFLEK EEEECPGVGC DYKAPLGKIP
NGSGYPPSKV AGKSQRAEKN STQCNGSSLQ SCRTDNRIKI SGYLNLLANT IDNFTHGLAV
AASFLVSRKV GFLTTMAILL HEIPHEVGDF AILLRAGFDR WSAAKMQLST ALGGIVGACF
AICAQSPKGA GETVAWILPF TSGGFLYIAL VNVVPDLLEE KNPWNSLQQI LLLCTGITVM
VLLAHN
