S39AD_DROME
ID S39AD_DROME Reviewed; 355 AA.
AC Q9VAF0; Q53YH2;
DT 24-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Zinc transporter ZIP13 homolog;
DE AltName: Full=Zinc/iron regulated transporter-related protein 99C;
GN Name=Zip99C; ORFNames=CG7816;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Head;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=23322169; DOI=10.1007/s00775-013-0976-6;
RA Lye J.C., Richards C.D., Dechen K., Warr C.G., Burke R.;
RT "In vivo zinc toxicity phenotypes provide a sensitized background that
RT suggests zinc transport activities for most of the Drosophila Zip and ZnT
RT genes.";
RL J. Biol. Inorg. Chem. 18:323-332(2013).
CC -!- FUNCTION: Involved in zinc transport and homeostasis.
CC {ECO:0000269|PubMed:23322169}.
CC -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC {ECO:0000269|PubMed:23322169}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:23322169}. Golgi apparatus membrane {ECO:0000305};
CC Multi-pass membrane protein {ECO:0000305}. Note=Also detected on
CC intracellular membranes.
CC -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC KE4/Catsup subfamily. {ECO:0000305}.
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DR EMBL; AE014297; AAN14194.1; -; Genomic_DNA.
DR EMBL; BT001774; AAN71529.1; -; mRNA.
DR RefSeq; NP_001189313.1; NM_001202384.1.
DR RefSeq; NP_001189314.1; NM_001202385.2.
DR RefSeq; NP_001189315.1; NM_001202386.2.
DR RefSeq; NP_733319.1; NM_170440.2.
DR RefSeq; NP_733320.1; NM_170441.2.
DR RefSeq; NP_733321.1; NM_170442.2.
DR RefSeq; NP_733322.1; NM_170443.3.
DR RefSeq; NP_733323.1; NM_170444.3.
DR RefSeq; NP_733324.1; NM_170445.2.
DR AlphaFoldDB; Q9VAF0; -.
DR BioGRID; 68392; 15.
DR IntAct; Q9VAF0; 1.
DR STRING; 7227.FBpp0088864; -.
DR TCDB; 2.A.5.4.20; the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.
DR GlyGen; Q9VAF0; 2 sites.
DR PaxDb; Q9VAF0; -.
DR PRIDE; Q9VAF0; -.
DR DNASU; 43533; -.
DR EnsemblMetazoa; FBtr0089920; FBpp0088859; FBgn0039714.
DR EnsemblMetazoa; FBtr0089921; FBpp0088860; FBgn0039714.
DR EnsemblMetazoa; FBtr0089922; FBpp0088861; FBgn0039714.
DR EnsemblMetazoa; FBtr0089923; FBpp0088862; FBgn0039714.
DR EnsemblMetazoa; FBtr0089924; FBpp0088863; FBgn0039714.
DR EnsemblMetazoa; FBtr0089925; FBpp0088864; FBgn0039714.
DR EnsemblMetazoa; FBtr0303032; FBpp0292151; FBgn0039714.
DR EnsemblMetazoa; FBtr0303033; FBpp0292152; FBgn0039714.
DR EnsemblMetazoa; FBtr0303034; FBpp0292153; FBgn0039714.
DR GeneID; 43533; -.
DR KEGG; dme:Dmel_CG7816; -.
DR UCSC; CG7816-RA; d. melanogaster.
DR CTD; 43533; -.
DR FlyBase; FBgn0039714; Zip99C.
DR VEuPathDB; VectorBase:FBgn0039714; -.
DR eggNOG; KOG2694; Eukaryota.
DR GeneTree; ENSGT00940000157349; -.
DR HOGENOM; CLU_015114_0_2_1; -.
DR InParanoid; Q9VAF0; -.
DR OMA; TGDSVHC; -.
DR OrthoDB; 657777at2759; -.
DR PhylomeDB; Q9VAF0; -.
DR SignaLink; Q9VAF0; -.
DR BioGRID-ORCS; 43533; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 43533; -.
DR PRO; PR:Q9VAF0; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0039714; Expressed in saliva-secreting gland and 28 other tissues.
DR ExpressionAtlas; Q9VAF0; baseline and differential.
DR Genevisible; Q9VAF0; DM.
DR GO; GO:0016323; C:basolateral plasma membrane; IDA:FlyBase.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:FlyBase.
DR GO; GO:0005794; C:Golgi apparatus; IDA:FlyBase.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005506; F:iron ion binding; IMP:FlyBase.
DR GO; GO:0005381; F:iron ion transmembrane transporter activity; IDA:FlyBase.
DR GO; GO:0005385; F:zinc ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0006882; P:cellular zinc ion homeostasis; IBA:GO_Central.
DR GO; GO:0010312; P:detoxification of zinc ion; IMP:FlyBase.
DR GO; GO:0006826; P:iron ion transport; IMP:FlyBase.
DR GO; GO:0060586; P:multicellular organismal iron ion homeostasis; IMP:FlyBase.
DR GO; GO:0071577; P:zinc ion transmembrane transport; IBA:GO_Central.
DR InterPro; IPR003689; ZIP.
DR Pfam; PF02535; Zip; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Glycoprotein; Golgi apparatus; Ion transport; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport; Zinc;
KW Zinc transport.
FT CHAIN 1..355
FT /note="Zinc transporter ZIP13 homolog"
FT /id="PRO_0000213694"
FT TRANSMEM 37..57
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 79..99
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 118..138
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..293
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 301..321
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 4
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 218
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 355 AA; 38870 MW; 01527C0390741FE8 CRC64;
MTTNSSFFDE HIAMIYSNLM DQYMPEYFKS FEYTPWVFSL LGSVVIGLSG IFPLIIIPTE
EKMAKEGYKD PADSKLLRVL LSFAVGGLLG DVFLHLLPEA WEGDNQDPSS HPSLRSGLWV
LSGILIFTIV EKIFSGYASA DEENPQPKCV EIANCLLRRH GGQLPEGETS ESCGGACDIE
DVGKVCFLRE QEQKSKERKE QPKKVAGYLN LLANSIDNFT HGLAVAGSFL VSFRHGILAT
FAILLHEIPH EVGDFAILLR SGFSRWDAAR AQLLTAGAGL LGALVAIGGS GVTSAMEART
SWIMPFTAGG FLHIALVTVL PDLLKEEERK ESIKQLLALV FGIALMAVMT MLFEH
