S39AD_MOUSE
ID S39AD_MOUSE Reviewed; 361 AA.
AC Q8BZH0; B7ZCF2; Q497M5; Q8VDX1; Q9D1R4;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Zinc transporter ZIP13;
DE AltName: Full=Solute carrier family 39 member 13;
DE AltName: Full=Zrt- and Irt-like protein 13;
DE Short=ZIP-13;
GN Name=Slc39a13; Synonyms=Zip13;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC STRAIN=C57BL/6J, and NOD; TISSUE=Spleen, and Urinary bladder;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
RC STRAIN=Czech II; TISSUE=Brain, Mammary tumor, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Acts as a zinc-influx transporter. {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-
CC pass membrane protein.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8BZH0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8BZH0-2; Sequence=VSP_029821;
CC Name=3;
CC IsoId=Q8BZH0-3; Sequence=VSP_029820, VSP_029822;
CC -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC {ECO:0000305}.
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DR EMBL; AK003191; BAB22631.1; -; mRNA.
DR EMBL; AK035296; BAC29020.1; -; mRNA.
DR EMBL; AK156951; BAE33911.1; -; mRNA.
DR EMBL; AL691439; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC100463; AAI00464.1; -; mRNA.
DR EMBL; BC020106; AAH20106.1; -; mRNA.
DR EMBL; BC125525; AAI25526.1; -; mRNA.
DR CCDS; CCDS16424.1; -. [Q8BZH0-1]
DR CCDS; CCDS71095.1; -. [Q8BZH0-2]
DR RefSeq; NP_001277694.1; NM_001290765.1. [Q8BZH0-2]
DR RefSeq; NP_080997.1; NM_026721.3. [Q8BZH0-1]
DR RefSeq; XP_006500162.1; XM_006500099.3. [Q8BZH0-2]
DR RefSeq; XP_017174725.1; XM_017319236.1. [Q8BZH0-1]
DR RefSeq; XP_017174727.1; XM_017319238.1. [Q8BZH0-3]
DR AlphaFoldDB; Q8BZH0; -.
DR SMR; Q8BZH0; -.
DR BioGRID; 212848; 3.
DR STRING; 10090.ENSMUSP00000107063; -.
DR TCDB; 2.A.5.4.9; the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.
DR PhosphoSitePlus; Q8BZH0; -.
DR MaxQB; Q8BZH0; -.
DR PaxDb; Q8BZH0; -.
DR PRIDE; Q8BZH0; -.
DR ProteomicsDB; 256575; -. [Q8BZH0-1]
DR ProteomicsDB; 256576; -. [Q8BZH0-2]
DR Antibodypedia; 26741; 62 antibodies from 22 providers.
DR DNASU; 68427; -.
DR Ensembl; ENSMUST00000073575; ENSMUSP00000073263; ENSMUSG00000002105. [Q8BZH0-1]
DR Ensembl; ENSMUST00000079976; ENSMUSP00000078892; ENSMUSG00000002105. [Q8BZH0-3]
DR Ensembl; ENSMUST00000111436; ENSMUSP00000107063; ENSMUSG00000002105. [Q8BZH0-2]
DR GeneID; 68427; -.
DR KEGG; mmu:68427; -.
DR UCSC; uc008kug.2; mouse. [Q8BZH0-1]
DR UCSC; uc008kuh.2; mouse. [Q8BZH0-2]
DR UCSC; uc008kui.2; mouse. [Q8BZH0-3]
DR CTD; 91252; -.
DR MGI; MGI:1915677; Slc39a13.
DR VEuPathDB; HostDB:ENSMUSG00000002105; -.
DR eggNOG; KOG2694; Eukaryota.
DR GeneTree; ENSGT00940000157349; -.
DR HOGENOM; CLU_015114_0_2_1; -.
DR InParanoid; Q8BZH0; -.
DR OMA; TGDSVHC; -.
DR OrthoDB; 657777at2759; -.
DR PhylomeDB; Q8BZH0; -.
DR TreeFam; TF318470; -.
DR BioGRID-ORCS; 68427; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Slc39a13; mouse.
DR PRO; PR:Q8BZH0; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q8BZH0; protein.
DR Bgee; ENSMUSG00000002105; Expressed in right kidney and 158 other tissues.
DR ExpressionAtlas; Q8BZH0; baseline and differential.
DR Genevisible; Q8BZH0; MM.
DR GO; GO:0005783; C:endoplasmic reticulum; ISO:MGI.
DR GO; GO:0005794; C:Golgi apparatus; IDA:BHF-UCL.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; ISO:MGI.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IDA:BHF-UCL.
DR GO; GO:0042803; F:protein homodimerization activity; ISO:MGI.
DR GO; GO:0005385; F:zinc ion transmembrane transporter activity; ISO:MGI.
DR GO; GO:0006882; P:cellular zinc ion homeostasis; IMP:BHF-UCL.
DR GO; GO:0061448; P:connective tissue development; IMP:BHF-UCL.
DR GO; GO:0071577; P:zinc ion transmembrane transport; IMP:BHF-UCL.
DR InterPro; IPR003689; ZIP.
DR Pfam; PF02535; Zip; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; Golgi apparatus; Ion transport; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport; Zinc;
KW Zinc transport.
FT CHAIN 1..361
FT /note="Zinc transporter ZIP13"
FT /id="PRO_0000312310"
FT TOPO_DOM 1..6
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 7..27
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 28..68
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 69..89
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 90..108
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 109..129
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 130..150
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 151..171
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 172..232
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 233..253
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 254..275
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 276..296
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 297..306
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 307..327
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 328..339
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 340..360
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 361
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT MOTIF 254..259
FT /note="XEXPHE-motif"
FT VAR_SEQ 1..167
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_029820"
FT VAR_SEQ 138
FT /note="P -> PATGLAWPVSAPPA (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_029821"
FT VAR_SEQ 179..212
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_029822"
FT CONFLICT 169
FT /note="F -> L (in Ref. 3; AAH20106)"
FT /evidence="ECO:0000305"
FT CONFLICT 173
FT /note="K -> Q (in Ref. 3; AAH20106)"
FT /evidence="ECO:0000305"
FT CONFLICT 360
FT /note="V -> A (in Ref. 3; AAH20106)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 361 AA; 38502 MW; 41CE56EE98FE9EDA CRC64;
MPGCPCPGCG MAGQRLLFLT VLALELLERA GGSQPALRSL GAAAACRLDN KESESWGALL
SGERLDTWIC SLLGSLMVGL SGVFPLLVIP LEMGTLLQSE AGAWRLRQLL SFALGGLLGN
VFLHLLPEAW AYTCNITPGG EGQSLQRQQQ LGLWVIAGFL TFLALEKMFL NSKEDPSQAP
SKDPTAAALN GGHCLAQPAA EPGLRAVVRN LKVSGYLNLL ANTIDNFTHG LAVAASFLVS
KKIGLLTTMA ILLHEIPHEV GDFAILLRAG FDRWTAAKLQ FSTALGGLLG ACFAICTQSP
KGVEETVVWI LPFTSGGFLY IALVNVLPDL LEEDDPWHSL QQVLLLCSGV LVMVLLSLFV
E
