ID   S39AD_PONAB             Reviewed;         328 AA.
AC   Q5R6I6;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 56.
DE   RecName: Full=Zinc transporter ZIP13;
DE   AltName: Full=Solute carrier family 39 member 13;
DE   AltName: Full=Zrt- and Irt-like protein 13;
DE            Short=ZIP-13;
GN   Name=SLC39A13; Synonyms=ZIP13;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a zinc-influx transporter. {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-
CC       pass membrane protein.
CC   -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC       {ECO:0000305}.
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DR   EMBL; CR860503; CAH92624.1; -; mRNA.
DR   RefSeq; NP_001127570.1; NM_001134098.1.
DR   AlphaFoldDB; Q5R6I6; -.
DR   SMR; Q5R6I6; -.
DR   Ensembl; ENSPPYT00000045661; ENSPPYP00000037686; ENSPPYG00000003305.
DR   GeneID; 100174648; -.
DR   KEGG; pon:100174648; -.
DR   CTD; 91252; -.
DR   GeneTree; ENSGT00940000157349; -.
DR   InParanoid; Q5R6I6; -.
DR   Proteomes; UP000001595; Chromosome 11.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0046873; F:metal ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006829; P:zinc ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR003689; ZIP.
DR   Pfam; PF02535; Zip; 2.
PE   2: Evidence at transcript level;
KW   Golgi apparatus; Ion transport; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport; Zinc; Zinc transport.
FT   CHAIN           1..328
FT                   /note="Zinc transporter ZIP13"
FT                   /id="PRO_0000312311"
FT   TOPO_DOM        1..7
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        8..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        29..68
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        69..89
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        90..108
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        109..129
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        130..149
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        150..170
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        171..199
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        200..220
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        221..242
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        243..263
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        264..273
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        274..294
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        295..306
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        307..327
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        328
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   MOTIF           221..226
FT                   /note="XEXPHE-motif"
SQ   SEQUENCE   328 AA;  34914 MW;  B770D5E1355631DC CRC64;
     MPGCPCPGCG MAGPRLLFLT ALALELLGRA GGSQPALRSR GTATACRLDN KESESWGALL
     SGERLDTWIC SLLGSLMVGL SGVFPLLVIP LEMGTMLRSE AGAWHLKQLL SFALGGLLGN
     VFLHLLPEAW AYTCSASPGG EGQSLQQQQQ LGLWVIAGIL TFLALEKMFL DSKEEGTSQV
     SGYLNLLANT IDNFTHGLAV AASFLVSKKI GLLTTMAILL HEIPHEVGDF AILLRAGFDR
     WSAAKLQLST ALGGLLGAGF AICTQSPKGV EETAAWVLPF TSGGFLYIAL VNVLPDLLEE
     EDPWRSLQQL LLLCAGIVVM VLFSLFVD