ID   S39AD_RAT               Reviewed;         361 AA.
AC   Q2M1K6;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-FEB-2006, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Zinc transporter ZIP13;
DE   AltName: Full=Solute carrier family 39 member 13;
DE   AltName: Full=Zrt- and Irt-like protein 13;
DE            Short=ZIP-13;
GN   Name=Slc39a13; Synonyms=Zip13;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Prostate;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Acts as a zinc-influx transporter. {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-
CC       pass membrane protein.
CC   -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC       {ECO:0000305}.
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DR   EMBL; BC112321; AAI12322.1; -; mRNA.
DR   RefSeq; NP_001034285.1; NM_001039196.1.
DR   AlphaFoldDB; Q2M1K6; -.
DR   SMR; Q2M1K6; -.
DR   STRING; 10116.ENSRNOP00000016191; -.
DR   PaxDb; Q2M1K6; -.
DR   GeneID; 295928; -.
DR   KEGG; rno:295928; -.
DR   UCSC; RGD:1304695; rat.
DR   CTD; 91252; -.
DR   RGD; 1304695; Slc39a13.
DR   VEuPathDB; HostDB:ENSRNOG00000011981; -.
DR   eggNOG; KOG2694; Eukaryota.
DR   HOGENOM; CLU_015114_0_2_1; -.
DR   InParanoid; Q2M1K6; -.
DR   OMA; TGDSVHC; -.
DR   OrthoDB; 657777at2759; -.
DR   PhylomeDB; Q2M1K6; -.
DR   TreeFam; TF318470; -.
DR   PRO; PR:Q2M1K6; -.
DR   Proteomes; UP000002494; Chromosome 3.
DR   Bgee; ENSRNOG00000011981; Expressed in skeletal muscle tissue and 20 other tissues.
DR   Genevisible; Q2M1K6; RN.
DR   GO; GO:0005783; C:endoplasmic reticulum; IDA:RGD.
DR   GO; GO:0005794; C:Golgi apparatus; ISO:RGD.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; ISO:RGD.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; ISO:RGD.
DR   GO; GO:0042803; F:protein homodimerization activity; ISO:RGD.
DR   GO; GO:0005385; F:zinc ion transmembrane transporter activity; ISO:RGD.
DR   GO; GO:0006882; P:cellular zinc ion homeostasis; ISO:RGD.
DR   GO; GO:0061448; P:connective tissue development; ISO:RGD.
DR   GO; GO:0010043; P:response to zinc ion; IEP:RGD.
DR   GO; GO:0071577; P:zinc ion transmembrane transport; ISO:RGD.
DR   InterPro; IPR003689; ZIP.
DR   Pfam; PF02535; Zip; 1.
PE   2: Evidence at transcript level;
KW   Golgi apparatus; Ion transport; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport; Zinc; Zinc transport.
FT   CHAIN           1..361
FT                   /note="Zinc transporter ZIP13"
FT                   /id="PRO_0000312312"
FT   TOPO_DOM        1..6
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        7..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        28..68
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        69..89
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        90..108
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        109..129
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        130..150
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        151..171
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        172..233
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        234..254
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        255..276
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        277..297
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        298..307
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        308..328
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        329..340
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        341..361
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOTIF           255..260
FT                   /note="XEXPHE-motif"
SQ   SEQUENCE   361 AA;  38398 MW;  8AC365D6F3A2BCB9 CRC64;
     MPGCPCPGCG MAGQRLLFLT VLALELLERA GGSQPALRSL GAAAACRLDS KESESWGALL
     SGERLDTWIC SLLGSLMVGL SGVFPLLVIP LEMGTMLQSE AGAWRLKQLL SFALGGLLGN
     VFLHLLPEAW AYTCNISPGV EGQSLQRQQQ LGLWVIAGFL TFLALEKMFL NCKEEDPSQA
     PSKDPTAAAL NGGHCLAQPA AEPGLRAVVR NLKVSGYLNL LANTIDNFTH GLAVAASFLV
     SKKIGLLTTM AILLHEIPHE VGDFAILLRA GFDRWTAAKL QFSTALGGLL GACFAICTQS
     PKGVEETVVW TLPFTSGGFL YVALVNVLPD LLEEDDPWHL NPPLPTGTPC SRCCCSAPVS
     W