ID   ABCGL_DICDI             Reviewed;        1449 AA.
AC   Q8T673; Q55C35;
DT   09-FEB-2010, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   03-AUG-2022, entry version 126.
DE   RecName: Full=ABC transporter G family member 21;
DE   AltName: Full=ABC transporter ABCG.21;
GN   Name=abcG21; Synonyms=abcG13; ORFNames=DDB_G0269206;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND NOMENCLATURE.
RC   STRAIN=AX4;
RX   PubMed=12456012; DOI=10.1128/ec.1.4.643-652.2002;
RA   Anjard C., Loomis W.F.;
RT   "Evolutionary analyses of ABC transporters of Dictyostelium discoideum.";
RL   Eukaryot. Cell 1:643-652(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCG family.
CC       PDR (TC 3.A.1.205) subfamily. {ECO:0000305}.
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DR   EMBL; AF482398; AAL91505.1; -; Genomic_DNA.
DR   EMBL; AAFI02000005; EAL71953.1; -; Genomic_DNA.
DR   RefSeq; XP_646646.1; XM_641554.1.
DR   AlphaFoldDB; Q8T673; -.
DR   SMR; Q8T673; -.
DR   STRING; 44689.DDB0191239; -.
DR   PaxDb; Q8T673; -.
DR   EnsemblProtists; EAL71953; EAL71953; DDB_G0269206.
DR   GeneID; 8617618; -.
DR   KEGG; ddi:DDB_G0269206; -.
DR   dictyBase; DDB_G0269206; abcG21.
DR   eggNOG; KOG0065; Eukaryota.
DR   HOGENOM; CLU_000604_35_0_1; -.
DR   InParanoid; Q8T673; -.
DR   OMA; VYGWKVF; -.
DR   PhylomeDB; Q8T673; -.
DR   PRO; PR:Q8T673; -.
DR   Proteomes; UP000002195; Chromosome 1.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IGC:dictyBase.
DR   GO; GO:0031152; P:aggregation involved in sorocarp development; IBA:GO_Central.
DR   GO; GO:0006972; P:hyperosmotic response; IEP:dictyBase.
DR   GO; GO:0031288; P:sorocarp morphogenesis; IBA:GO_Central.
DR   CDD; cd03233; ABCG_PDR_domain1; 1.
DR   CDD; cd03232; ABCG_PDR_domain2; 1.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR013525; ABC_2_trans.
DR   InterPro; IPR029481; ABC_trans_N.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR043926; ABCG_dom.
DR   InterPro; IPR034001; ABCG_PDR_1.
DR   InterPro; IPR034003; ABCG_PDR_2.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010929; PDR_CDR_ABC.
DR   Pfam; PF01061; ABC2_membrane; 2.
DR   Pfam; PF19055; ABC2_membrane_7; 1.
DR   Pfam; PF00005; ABC_tran; 2.
DR   Pfam; PF14510; ABC_trans_N; 1.
DR   Pfam; PF06422; PDR_CDR; 1.
DR   SMART; SM00382; AAA; 2.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE   3: Inferred from homology;
KW   ATP-binding; Membrane; Nucleotide-binding; Reference proteome; Repeat;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..1449
FT                   /note="ABC transporter G family member 21"
FT                   /id="PRO_0000391404"
FT   TRANSMEM        519..539
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        577..597
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        602..622
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        634..654
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        747..767
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1155..1175
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1188..1208
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1228..1248
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1266..1286
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1296..1316
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1423..1443
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          130..383
FT                   /note="ABC transporter 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   DOMAIN          488..731
FT                   /note="ABC transmembrane type-2 1"
FT   DOMAIN          818..1062
FT                   /note="ABC transporter 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   DOMAIN          1152..1386
FT                   /note="ABC transmembrane type-2 2"
FT   REGION          1..49
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        15..29
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         854..861
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ   SEQUENCE   1449 AA;  165610 MW;  228A3FFA42AAFBAF CRC64;
     MEEYELREIA LQEGGSNLDI NTPPNYDNPV GDGSSPPDSP DIQKSENQFK NVERELEIDS
     KQYLAGHDAE NNHDENDEDF KLRRYFENSQ RMALGNGQKP KKMGVSIRNL TVVGRGADQS
     VIADMSTPFI SFFNLFKPST WKEKGSTFDI LHDITLFNRD GGMLLVLGRP GSGCSTLLRL
     ISNQRGSYVE VKGDIKYGGI PAKEWKRYQG ESIYTPEEDT HHPTLTVRQT LDFALKCKTI
     HNRLPDEKKR TYRQKIFDLL LGMFGIVHQA DTIVGNEFIR GLSGGERKRL TITEAMVSSA
     SITCYDCSTR GLDAASALDY AKSIRIMSDT LDKTTIASFY QASDSIYNLF DNVAIIEKGR
     LIYFGPGNKA KQYFIDLGFD CEPRKSTPDF LTGVTNPQER IIRQGFEGRV PETSADFEAA
     WRNSSMYRDM LEEQKEYERK IEIEQPAVDF IQEVKAEKSR TTPKRSIYTT SYITQVKALI
     VRNSQIIWGD KFSLISRYLS VFTQSFVYGS IFFQMEKTIP GLFTRGGAIF SAILFNAFLS
     EAELPLTMYG RRILQKQRSY AMYRPSALHI AQIVTDIPLT MIQVFLFSIV VYFMFGLQYN
     AGKFFIFCFT LVGATLATTN LFRVFGNFSP SLYISQNVMN VILIFMITYC GYTIPKPKMH
     PWFAWFYWAN PFSYAFKALM ANEFGDLSFD CHDTAIPFDP KNPTRYDNDY RVCASPGAVE
     GILSVEGKDY LDQYLHFRSD DLTQNVFITY LWWVLFTAMN MFAMEYFDWT GGGYSHKVYK
     KGKAPKMNDA EEEKKQNQIV ANATSKMKDT LKMRGGIFTW QNINYTVPVK GGKRLLLDNV
     EGWIKPGQMT ALMGSSGAGK TTLLDVLAKR KTMGEVQGKC FLNGKPLEID FERITGYVEQ
     MDVHNPGLTV REALRFSAKL RQEPSVSLEE KFDYVEHVLE MMEMKHLGDA LIGTLETGVG
     ISVEERKRLT IGVELVAKPH ILFLDEPTSG LDAQSSYNIV KFIRKLADAG MPLVCTIHQP
     SSVLFEHFDR ILLLAKGGKT VYFGDIGERS KTLTSYFERY GVRPCTESEN PAEYILEATG
     AGVHGKSDVN WPETWKQSPE LQEIERELAA LEAAGPSSTE DHGKPREFAT SVWYQTIEVY
     KRLNLIWWRD PFYTYGSFIQ SALAGLIIGF TFWSLQGSSS DMNQRVFFIF EALILGILLI
     FVVLPQFIMQ KEYFKRDFAS KFYSWFPFAI SIVVVELPFI TVSGTIFFFC SFWTAGLNTE
     YNDINFYFWF IFILFLYFCV SFGQAVAAIC FNMFLAHTLI PLLIVFLFLF CGVMVIPSSI
     PTFWRGWVYH LNPCRYFMEG IVTNVLKHTD VKCTSEDFTH FTNPEAVNGV TCKQYFPISE
     PLTGYVEAIN EGDESKCGYC LYNNGEEYYN TLGWSFDNRW RNLALIICFW IFNTLMVITF
     VYITRKPRR