S3TC1_HUMAN
ID S3TC1_HUMAN Reviewed; 1336 AA.
AC Q8TE82; Q4W5G5;
DT 04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT 30-NOV-2010, sequence version 3.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=SH3 domain and tetratricopeptide repeat-containing protein 1;
GN Name=SH3TC1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT PRO-437.
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-1248, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [4]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-terminal
RT acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
RN [5]
RP VARIANTS [LARGE SCALE ANALYSIS] HIS-719 AND THR-1130.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK074402; BAB85071.1; -; mRNA.
DR EMBL; AC104650; AAY40932.1; -; Genomic_DNA.
DR CCDS; CCDS3399.1; -.
DR RefSeq; NP_001305409.1; NM_001318480.1.
DR RefSeq; NP_061859.3; NM_018986.4.
DR RefSeq; XP_011511790.1; XM_011513488.1.
DR RefSeq; XP_016863789.1; XM_017008300.1.
DR AlphaFoldDB; Q8TE82; -.
DR BioGRID; 119952; 4.
DR IntAct; Q8TE82; 2.
DR MINT; Q8TE82; -.
DR STRING; 9606.ENSP00000245105; -.
DR iPTMnet; Q8TE82; -.
DR PhosphoSitePlus; Q8TE82; -.
DR SwissPalm; Q8TE82; -.
DR BioMuta; SH3TC1; -.
DR DMDM; 313104192; -.
DR EPD; Q8TE82; -.
DR jPOST; Q8TE82; -.
DR MassIVE; Q8TE82; -.
DR MaxQB; Q8TE82; -.
DR PaxDb; Q8TE82; -.
DR PeptideAtlas; Q8TE82; -.
DR PRIDE; Q8TE82; -.
DR ProteomicsDB; 74419; -.
DR TopDownProteomics; Q8TE82; -.
DR Antibodypedia; 52212; 107 antibodies from 19 providers.
DR DNASU; 54436; -.
DR Ensembl; ENST00000245105.8; ENSP00000245105.3; ENSG00000125089.18.
DR Ensembl; ENST00000457650.7; ENSP00000390311.3; ENSG00000125089.18.
DR GeneID; 54436; -.
DR KEGG; hsa:54436; -.
DR MANE-Select; ENST00000245105.8; ENSP00000245105.3; NM_018986.5; NP_061859.4.
DR UCSC; uc003gkv.5; human.
DR CTD; 54436; -.
DR DisGeNET; 54436; -.
DR GeneCards; SH3TC1; -.
DR HGNC; HGNC:26009; SH3TC1.
DR HPA; ENSG00000125089; Tissue enhanced (lymphoid).
DR neXtProt; NX_Q8TE82; -.
DR OpenTargets; ENSG00000125089; -.
DR PharmGKB; PA128394666; -.
DR VEuPathDB; HostDB:ENSG00000125089; -.
DR eggNOG; ENOG502QUY4; Eukaryota.
DR GeneTree; ENSGT00530000063812; -.
DR HOGENOM; CLU_004832_0_0_1; -.
DR InParanoid; Q8TE82; -.
DR OMA; MTFQGGD; -.
DR OrthoDB; 39940at2759; -.
DR PhylomeDB; Q8TE82; -.
DR TreeFam; TF333167; -.
DR PathwayCommons; Q8TE82; -.
DR SignaLink; Q8TE82; -.
DR BioGRID-ORCS; 54436; 13 hits in 1073 CRISPR screens.
DR ChiTaRS; SH3TC1; human.
DR GenomeRNAi; 54436; -.
DR Pharos; Q8TE82; Tdark.
DR PRO; PR:Q8TE82; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; Q8TE82; protein.
DR Bgee; ENSG00000125089; Expressed in thymus and 115 other tissues.
DR ExpressionAtlas; Q8TE82; baseline and differential.
DR Gene3D; 1.25.40.10; -; 4.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR042772; SH3TC1/SH3TC2.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR22647; PTHR22647; 1.
DR SMART; SM00326; SH3; 1.
DR SMART; SM00028; TPR; 6.
DR SUPFAM; SSF48452; SSF48452; 4.
DR SUPFAM; SSF50044; SSF50044; 1.
DR PROSITE; PS50002; SH3; 1.
PE 1: Evidence at protein level;
KW Acetylation; Phosphoprotein; Reference proteome; Repeat; SH3 domain;
KW TPR repeat.
FT CHAIN 1..1336
FT /note="SH3 domain and tetratricopeptide repeat-containing
FT protein 1"
FT /id="PRO_0000106355"
FT DOMAIN 305..368
FT /note="SH3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT REPEAT 560..593
FT /note="TPR 1"
FT REPEAT 601..634
FT /note="TPR 2"
FT REPEAT 665..698
FT /note="TPR 3"
FT REPEAT 786..819
FT /note="TPR 4"
FT REPEAT 863..896
FT /note="TPR 5"
FT REPEAT 946..979
FT /note="TPR 6"
FT REPEAT 1027..1063
FT /note="TPR 7"
FT REPEAT 1192..1225
FT /note="TPR 8"
FT REPEAT 1277..1311
FT /note="TPR 9"
FT REGION 1..76
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 225..266
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0007744|PubMed:22814378"
FT MOD_RES 1248
FT /note="Phosphotyrosine"
FT /evidence="ECO:0007744|PubMed:19690332"
FT VARIANT 291
FT /note="D -> N (in dbSNP:rs1281138)"
FT /id="VAR_034127"
FT VARIANT 437
FT /note="L -> P (in dbSNP:rs1281145)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_034128"
FT VARIANT 719
FT /note="R -> H (in a colorectal cancer sample; somatic
FT mutation; dbSNP:rs201295499)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_035866"
FT VARIANT 785
FT /note="R -> C (in dbSNP:rs1281149)"
FT /id="VAR_021934"
FT VARIANT 1130
FT /note="A -> T (in a colorectal cancer sample; somatic
FT mutation; dbSNP:rs1348201855)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_035867"
FT CONFLICT 1016
FT /note="L -> P (in Ref. 1; BAB85071)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1336 AA; 146961 MW; 0653B347D6B2500A CRC64;
MENLPAVTTE EPTPMGRGPV GPSGGGSTRD QVRTVVMRPS VSWEKAGPEE AKAPVRGDEA
PPARVAGPAA GTPPCQMGVY PTDLTLQLLA VRRKSRLRDP GLQQTLRGQL RLLENDSREM
ARVLGELSAR LLSIHSDQDR IVVTFKTFEE IWKFSTYHAL GFTHHCLANL LMDQAFWLLL
PSEEEETAIQ VHVDENALRL THESLLIQEG PFFVLCPDHH VRVMTGPRDA GNGPQALRQA
SGAPQGEAAP ETDSSPPSPS VSSEEVAVAA APEPLIPFHQ WALRIPQDPI DDAMGGPVMP
GNPLMAVGLA SALADFQGSG PEEMTFRGGD LIEILGAQVP SLPWCVGRHA ASGRVGFVRS
SLISMQGPVS ELESAIFLNE EEKSFFSEGC FSEEDARQLL RRMSGTDVCS VYSLDSVEEA
ETEQPQEKEI PPPCLSLEPQ ETLQKVKNVL EQCKTCPGCP QEPASWGLCA ASSDVSLQDP
EEPSFCLEAE DDWEDPEALS SLLLFLNAPG YKASFRGLYD VALPWLSSVF RSFSDEEELT
GRLAQARGAA KKAGLLMALA RLCFLLGRLC SRRLKLSQAR VYFEEALGAL EGSFGDLFLV
VAVYANLASI YRKQKNREKC AQVVPKAMAL LLGTPDHICS TEAEGELLQL ALRRAVGGQS
LQAEARACFL LARHHVHLKQ PEEALPFLER LLLLHRDSGA PEAAWLSDCY LLLADIYSRK
CLPHLVLSCV KVASLRTRGS LAGSLRSVNL VLQNAPQPHS LPAQTSHYLR QALASLTPGT
GQALRGPLYT SLAQLYSHHG CHGPAITFMT QAVEASAIAG VRAIVDHLVA LAWLHVLHGQ
SPVALDILQS VRDAVVASED QEGVIANMVA VALKRTGRTR QAAESYYRAL RVARDLGQQR
NQAVGLANFG ALCLHAGASR LAQHYLLEAV RLFSRLPLGE CGRDFTHVLL QLGHLCTRQG
PAQQGKGYYE WALLVAVEMG HVESQLRAVQ RLCHFYSAVM PSEAQCVIYH ELQLSLACKV
ADKVLEGQLL ETISQLYLSL GTERAYKSAL DYTKRSLGIF IDLQKKEKEA HAWLQAGKIY
YILRQSELVD LYIQVAQNVA LYTGDPNLGL ELFEAAGDIF FDGAWEREKA VSFYRDRALP
LAVTTGNRKA ELRLCNKLVA LLATLEEPQE GLEFAHMALA LSITLGDRLN ERVAYHRLAA
LQHRLGHGEL AEHFYLKALS LCNSPLEFDE ETLYYVKVYL VLGDIIFYDL KDPFDAAGYY
QLALAAAVDL GNKKAQLKIY TRLATIYHNF LLDREKSLFF YQKARTFATE LNVRRVNLPP
LPLCGWAPWL APSHPR
