S3TC2_HUMAN
ID S3TC2_HUMAN Reviewed; 1288 AA.
AC Q8TF17; B3KWE5; Q14CC0; Q14CF5; Q9H8I5;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 13-APR-2004, sequence version 2.
DT 03-AUG-2022, entry version 171.
DE RecName: Full=SH3 domain and tetratricopeptide repeat-containing protein 2;
GN Name=SH3TC2; Synonyms=KIAA1985; ORFNames=PP12494;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, AND VARIANTS
RP CMT4C GLN-529; LYS-657 AND CYS-658.
RC TISSUE=Sciatic nerve;
RX PubMed=14574644; DOI=10.1086/379525;
RA Senderek J., Bergmann C., Stendel C., Kirfel J., Verpoorten N.,
RA De Jonghe P., Timmerman V., Chrast R., Verheijen M.H.G., Lemke G.,
RA Battaloglu E., Parman Y., Erdem S., Tan E., Topaloglu H., Hahn A.,
RA Mueller-Felber W., Rizzuto N., Fabrizi G.M., Stuhrmann M.,
RA Rudnik-Schoeneborn S., Zuechner S., Schroeder J.M., Buchheim E., Straub V.,
RA Klepper J., Huehne K., Rautenstrauss B., Buettner R., Nelis E., Zerres K.;
RT "Mutations in a gene encoding a novel SH3/TPR domain protein cause
RT autosomal recessive Charcot-Marie-Tooth type 4C neuropathy.";
RL Am. J. Hum. Genet. 73:1106-1119(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4).
RC TISSUE=Hippocampus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RX PubMed=15498874; DOI=10.1073/pnas.0404089101;
RA Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X.,
RA Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.,
RA Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.;
RT "Large-scale cDNA transfection screening for genes related to cancer
RT development and progression.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15372022; DOI=10.1038/nature02919;
RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT "The DNA sequence and comparative analysis of human chromosome 5.";
RL Nature 431:268-274(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 5), AND VARIANT
RP SER-468.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 334-1288 (ISOFORM 1), AND VARIANT
RP SER-468.
RC TISSUE=Brain;
RX PubMed=11853319; DOI=10.1093/dnares/8.6.319;
RA Nagase T., Kikuno R., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XXII. The
RT complete sequences of 50 new cDNA clones which code for large proteins.";
RL DNA Res. 8:319-327(2001).
RN [8]
RP VARIANT MNMN HIS-169.
RX PubMed=20220177; DOI=10.1056/nejmoa0908094;
RA Lupski J.R., Reid J.G., Gonzaga-Jauregui C., Rio Deiros D., Chen D.C.,
RA Nazareth L., Bainbridge M., Dinh H., Jing C., Wheeler D.A., McGuire A.L.,
RA Zhang F., Stankiewicz P., Halperin J.J., Yang C., Gehman C., Guo D.,
RA Irikat R.K., Tom W., Fantin N.J., Muzny D.M., Gibbs R.A.;
RT "Whole-genome sequencing in a patient with Charcot-Marie-Tooth
RT neuropathy.";
RL N. Engl. J. Med. 362:1181-1191(2010).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Name=1;
CC IsoId=Q8TF17-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8TF17-2; Sequence=VSP_009884, VSP_009885;
CC Name=3;
CC IsoId=Q8TF17-3; Sequence=VSP_009884, VSP_009885, VSP_009886;
CC Name=4;
CC IsoId=Q8TF17-4; Sequence=VSP_009881, VSP_009882, VSP_009883;
CC Name=5;
CC IsoId=Q8TF17-5; Sequence=VSP_054499;
CC -!- TISSUE SPECIFICITY: Strongly expressed in brain and spinal cord.
CC Expressed at equal level in spinal cord and sciatic nerve. Weakly
CC expressed in striated muscle. {ECO:0000269|PubMed:14574644}.
CC -!- DISEASE: Charcot-Marie-Tooth disease 4C (CMT4C) [MIM:601596]: A
CC recessive demyelinating form of Charcot-Marie-Tooth disease, a disorder
CC of the peripheral nervous system, characterized by progressive weakness
CC and atrophy, initially of the peroneal muscles and later of the distal
CC muscles of the arms. Charcot-Marie-Tooth disease is classified in two
CC main groups on the basis of electrophysiologic properties and
CC histopathology: primary peripheral demyelinating neuropathies
CC (designated CMT1 when they are dominantly inherited) and primary
CC peripheral axonal neuropathies (CMT2). Demyelinating neuropathies are
CC characterized by severely reduced nerve conduction velocities (less
CC than 38 m/sec), segmental demyelination and remyelination with onion
CC bulb formations on nerve biopsy, slowly progressive distal muscle
CC atrophy and weakness, absent deep tendon reflexes, and hollow feet. By
CC convention autosomal recessive forms of demyelinating Charcot-Marie-
CC Tooth disease are designated CMT4. CMT4C is characterized by onset in
CC childhood, early-onset scoliosis and a distinct Schwann cell pathology.
CC {ECO:0000269|PubMed:14574644}. Note=The disease is caused by variants
CC affecting the gene represented in this entry.
CC -!- DISEASE: Mononeuropathy of the median nerve mild (MNMN) [MIM:613353]: A
CC disease characterized by median nerve mononeuropathy at the wrist. The
CC clinical presentation ranges from a mild phenotype, consistent with
CC carpal tunnel syndrome, to a severe median nerve mononeuropathy at the
CC wrist associated with evidence of a more widespread axonal
CC polyneuropathy. The latter phenotype is similar to that of patients
CC with hereditary neuropathy with liability to pressure palsies.
CC {ECO:0000269|PubMed:20220177}. Note=The disease is caused by variants
CC affecting the gene represented in this entry.
CC -!- WEB RESOURCE: Name=Inherited peripheral neuropathies mutation db;
CC URL="https://uantwerpen.vib.be/CMTMutations";
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DR EMBL; AY341075; AAR03497.1; -; mRNA.
DR EMBL; AK124854; BAG54107.1; -; mRNA.
DR EMBL; AK127248; BAC86899.1; -; mRNA.
DR EMBL; AK023667; BAB14631.1; -; mRNA.
DR EMBL; AF370410; AAQ15246.1; -; mRNA.
DR EMBL; AC011364; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC116312; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471062; EAW61796.1; -; Genomic_DNA.
DR EMBL; BC113879; AAI13880.1; -; mRNA.
DR EMBL; BC114486; AAI14487.1; -; mRNA.
DR EMBL; AB075865; BAB85571.1; -; mRNA.
DR CCDS; CCDS4293.1; -. [Q8TF17-1]
DR RefSeq; NP_078853.2; NM_024577.3. [Q8TF17-1]
DR AlphaFoldDB; Q8TF17; -.
DR STRING; 9606.ENSP00000423660; -.
DR iPTMnet; Q8TF17; -.
DR PhosphoSitePlus; Q8TF17; -.
DR BioMuta; SH3TC2; -.
DR DMDM; 46396469; -.
DR EPD; Q8TF17; -.
DR jPOST; Q8TF17; -.
DR MassIVE; Q8TF17; -.
DR PaxDb; Q8TF17; -.
DR PeptideAtlas; Q8TF17; -.
DR PRIDE; Q8TF17; -.
DR ProteomicsDB; 60324; -.
DR ProteomicsDB; 74536; -. [Q8TF17-1]
DR ProteomicsDB; 74539; -. [Q8TF17-4]
DR Antibodypedia; 49222; 83 antibodies from 17 providers.
DR DNASU; 79628; -.
DR Ensembl; ENST00000512049.5; ENSP00000421860.1; ENSG00000169247.14. [Q8TF17-5]
DR Ensembl; ENST00000515425.6; ENSP00000423660.1; ENSG00000169247.14. [Q8TF17-1]
DR GeneID; 79628; -.
DR KEGG; hsa:79628; -.
DR MANE-Select; ENST00000515425.6; ENSP00000423660.1; NM_024577.4; NP_078853.2.
DR UCSC; uc003lpu.4; human. [Q8TF17-1]
DR CTD; 79628; -.
DR DisGeNET; 79628; -.
DR GeneCards; SH3TC2; -.
DR GeneReviews; SH3TC2; -.
DR HGNC; HGNC:29427; SH3TC2.
DR HPA; ENSG00000169247; Group enriched (brain, retina).
DR MalaCards; SH3TC2; -.
DR MIM; 601596; phenotype.
DR MIM; 608206; gene.
DR MIM; 613353; phenotype.
DR neXtProt; NX_Q8TF17; -.
DR OpenTargets; ENSG00000169247; -.
DR Orphanet; 99949; Charcot-Marie-Tooth disease type 4C.
DR PharmGKB; PA134951912; -.
DR VEuPathDB; HostDB:ENSG00000169247; -.
DR eggNOG; ENOG502R9YA; Eukaryota.
DR GeneTree; ENSGT00530000063812; -.
DR HOGENOM; CLU_1739912_0_0_1; -.
DR InParanoid; Q8TF17; -.
DR OMA; HLETMYL; -.
DR OrthoDB; 39940at2759; -.
DR PhylomeDB; Q8TF17; -.
DR TreeFam; TF333167; -.
DR PathwayCommons; Q8TF17; -.
DR BioGRID-ORCS; 79628; 10 hits in 1066 CRISPR screens.
DR ChiTaRS; SH3TC2; human.
DR GeneWiki; SH3TC2; -.
DR GenomeRNAi; 79628; -.
DR Pharos; Q8TF17; Tbio.
DR PRO; PR:Q8TF17; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q8TF17; protein.
DR Bgee; ENSG00000169247; Expressed in corpus callosum and 108 other tissues.
DR ExpressionAtlas; Q8TF17; baseline and differential.
DR Genevisible; Q8TF17; HS.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0055037; C:recycling endosome; IBA:GO_Central.
DR GO; GO:0032287; P:peripheral nervous system myelin maintenance; IEA:Ensembl.
DR GO; GO:1901184; P:regulation of ERBB signaling pathway; IBA:GO_Central.
DR GO; GO:0033157; P:regulation of intracellular protein transport; IBA:GO_Central.
DR Gene3D; 1.25.40.10; -; 2.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR042772; SH3TC1/SH3TC2.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR22647; PTHR22647; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00326; SH3; 1.
DR SMART; SM00028; TPR; 4.
DR SUPFAM; SSF48452; SSF48452; 3.
DR SUPFAM; SSF50044; SSF50044; 1.
DR PROSITE; PS50002; SH3; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Charcot-Marie-Tooth disease; Disease variant;
KW Neurodegeneration; Neuropathy; Reference proteome; Repeat; SH3 domain;
KW TPR repeat.
FT CHAIN 1..1288
FT /note="SH3 domain and tetratricopeptide repeat-containing
FT protein 2"
FT /id="PRO_0000106356"
FT DOMAIN 176..240
FT /note="SH3 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT DOMAIN 268..331
FT /note="SH3 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT REPEAT 528..561
FT /note="TPR 1"
FT REPEAT 757..790
FT /note="TPR 2"
FT REPEAT 836..869
FT /note="TPR 3"
FT REPEAT 1001..1037
FT /note="TPR 4"
FT REPEAT 1084..1118
FT /note="TPR 5"
FT REPEAT 1119..1152
FT /note="TPR 6"
FT REPEAT 1166..1199
FT /note="TPR 7"
FT REPEAT 1210..1244
FT /note="TPR 8"
FT REGION 386..405
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 410..444
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 413..433
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..1138
FT /note="Missing (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15498874"
FT /id="VSP_009884"
FT VAR_SEQ 1..453
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_009881"
FT VAR_SEQ 128..134
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_054499"
FT VAR_SEQ 959..1049
FT /note="QLQATKSLCHFYSSVSPNPEACITYHEHWLALAQQLRDREMEGRLLESLGQL
FT YRNLNTARSLRRSLTCIKESLRIFIDLGETDKAAEAWLG -> KYVPCCWEAIERSVGS
FT SFIHFLSQVISFMSLLCVQVSFRPPNPSAISTALCPQTLRHASPTMSTGWPWLSNSGTG
FT RWKEGCWSPWGSFIGT (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_009882"
FT VAR_SEQ 1050..1288
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_009883"
FT VAR_SEQ 1139..1159
FT /note="LEGYEKALEFATLAARLSTVT -> MSEQMMQSVGCRISLSVFQFL (in
FT isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15498874"
FT /id="VSP_009885"
FT VAR_SEQ 1226..1288
FT /note="DAHDATEYFLLALAAAVLLGDEELQDTIRSRLDNICQSPLWHSRPSGCSSER
FT ARWLSGGGLAL -> VRARLPRFPDSHHPTILLPDSKTMRSLCGGAEKTRVPR (in
FT isoform 3)"
FT /evidence="ECO:0000303|PubMed:15498874"
FT /id="VSP_009886"
FT VARIANT 169
FT /note="Y -> H (in MNMN; dbSNP:rs80359890)"
FT /evidence="ECO:0000269|PubMed:20220177"
FT /id="VAR_064421"
FT VARIANT 171
FT /note="G -> E (in dbSNP:rs17722293)"
FT /id="VAR_052622"
FT VARIANT 468
FT /note="A -> S (in dbSNP:rs6875902)"
FT /evidence="ECO:0000269|PubMed:11853319,
FT ECO:0000269|PubMed:15489334"
FT /id="VAR_018267"
FT VARIANT 529
FT /note="R -> Q (in CMT4C; dbSNP:rs863224454)"
FT /evidence="ECO:0000269|PubMed:14574644"
FT /id="VAR_018268"
FT VARIANT 657
FT /note="E -> K (in CMT4C; dbSNP:rs80338925)"
FT /evidence="ECO:0000269|PubMed:14574644"
FT /id="VAR_018269"
FT VARIANT 658
FT /note="R -> C (in CMT4C; dbSNP:rs80338926)"
FT /evidence="ECO:0000269|PubMed:14574644"
FT /id="VAR_018270"
FT VARIANT 696
FT /note="H -> R (in dbSNP:rs17109261)"
FT /id="VAR_052623"
FT CONFLICT 334
FT /note="M -> R (in Ref. 7; BAB85571)"
FT /evidence="ECO:0000305"
FT CONFLICT 1158
FT /note="V -> I (in Ref. 7; BAB85571)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1288 AA; 144777 MW; 0E7C1B87480207B4 CRC64;
MGGCFCIPRE RSLTRGPGKE TPSKDPTVSS ECIASSEYKE KCFLPQNINP DLTLSFCVKS
RSRRCVNGPL QEAARRRLWA LENEDQEVRM LFKDLSARLV SIQSQRAQFL ITFKTMEEIW
KFSTYLNLGY VSMCLEHLLF DHKYWLNCIL VEDTEIQVSV DDKHLETIYL GLLIQEGHFF
CRALCSVTPP AEKEGECLTL CKNELISVKM AEAGSELEGV SLVTGQRGLV LVSALEPLPL
PFHQWFLKNY PGSCGLSRKR DWTGSYQIGR GRCKALTGYE PGEKDELNFY QGESIEIIGF
VIPGLQWFIG KSTSSGQVGF VPTRNIDPDS YSPMSRNSAF LSDEERCSLL ALGSDKQTEC
SSFLHTLART DITSVYRLSG FESIQNPPND LSASQPEGFK EVRPGRAWEE HQAVGSRQSS
SSEDSSLEEE LLSATSDSYR LPEPDDLDDP ELLMDLSTGQ EEEAENFAPI LAFLDHEGYA
DHFKSLYDFS FSFLTSSFYS FSEEDEFVAY LEASRKWAKK SHMTWAHARL CFLLGRLSIR
KVKLSQARVY FEEAIHILNG AFEDLSLVAT LYINLAAIYL KQRLRHKGSA LLEKAGALLA
CLPDRESSAK HELDVVAYVL RQGIVVGSSP LEARACFLAI RLLLSLGRHE EVLPFAERLQ
LLSGHPPASE AVASVLSFLY DKKYLPHLAV ASVQQHGIQS AQGMSLPIWQ VHLVLQNTTK
LLGFPSPGWG EVSALACPML RQALAACEEL ADRSTQRALC LILSKVYLEH RSPDGAIHYL
SQALVLGQLL GEQESFESSL CLAWAYLLAS QAKKALDVLE PLLCSLKETE SLTQRGVIYN
LLGLALQGEG RVNRAAKSYL RALNRAQEVG DVHNQAVAMA NLGHLSLKSW AQHPARNYLL
QAVRLYCELQ ASKETDMELV QVFLWLAQVL VSGHQLTHGL LCYEMALLFG LRHRHLKSQL
QATKSLCHFY SSVSPNPEAC ITYHEHWLAL AQQLRDREME GRLLESLGQL YRNLNTARSL
RRSLTCIKES LRIFIDLGET DKAAEAWLGA GRLHYLMQED ELVELCLQAA IQTALKSEEP
LLALKLYEEA GDVFFNGTRH RHHAVEYYRA GAVPLARRLK AVRTELRIFN KLTELQISLE
GYEKALEFAT LAARLSTVTG DQRQELVAFH RLATVYYSLH MYEMAEDCYL KTLSLCPPWL
QSPKEALYYA KVYYRLGRLT FCQLKDAHDA TEYFLLALAA AVLLGDEELQ DTIRSRLDNI
CQSPLWHSRP SGCSSERARW LSGGGLAL
