S3TC2_MOUSE
ID S3TC2_MOUSE Reviewed; 1289 AA.
AC Q80VA5; Q8BWH2; Q8BXB8; Q8C0G6;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 13-APR-2004, sequence version 2.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=SH3 domain and tetratricopeptide repeat-containing protein 2;
GN Name=Sh3tc2; Synonyms=Kiaa1985;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 4).
RC STRAIN=C57BL/6J; TISSUE=Head, Lung, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 959-1289 (ISOFORM 1).
RC STRAIN=C57BL/6J, and FVB/N; TISSUE=Kidney, Mammary tumor, and Pituitary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q80VA5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q80VA5-2; Sequence=VSP_009887, VSP_009892;
CC Name=3;
CC IsoId=Q80VA5-3; Sequence=VSP_009888, VSP_009889;
CC Name=4;
CC IsoId=Q80VA5-4; Sequence=VSP_009890, VSP_009891;
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DR EMBL; AK031388; BAC27379.1; -; mRNA.
DR EMBL; AK048066; BAC33233.1; -; mRNA.
DR EMBL; AK052534; BAC35030.1; -; mRNA.
DR EMBL; BC037000; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BC049856; AAH49856.1; -; mRNA.
DR CCDS; CCDS37840.1; -. [Q80VA5-1]
DR RefSeq; NP_766216.2; NM_172628.2. [Q80VA5-1]
DR AlphaFoldDB; Q80VA5; -.
DR STRING; 10090.ENSMUSP00000055094; -.
DR iPTMnet; Q80VA5; -.
DR PhosphoSitePlus; Q80VA5; -.
DR MaxQB; Q80VA5; -.
DR PaxDb; Q80VA5; -.
DR PRIDE; Q80VA5; -.
DR ProteomicsDB; 253382; -. [Q80VA5-1]
DR ProteomicsDB; 253383; -. [Q80VA5-2]
DR ProteomicsDB; 253384; -. [Q80VA5-3]
DR ProteomicsDB; 253385; -. [Q80VA5-4]
DR Antibodypedia; 49222; 83 antibodies from 17 providers.
DR DNASU; 225608; -.
DR Ensembl; ENSMUST00000051720; ENSMUSP00000055094; ENSMUSG00000045629. [Q80VA5-1]
DR Ensembl; ENSMUST00000235652; ENSMUSP00000158542; ENSMUSG00000045629. [Q80VA5-4]
DR GeneID; 225608; -.
DR KEGG; mmu:225608; -.
DR UCSC; uc008fcu.1; mouse. [Q80VA5-3]
DR UCSC; uc008fcv.1; mouse. [Q80VA5-1]
DR UCSC; uc008fcw.1; mouse. [Q80VA5-2]
DR CTD; 79628; -.
DR MGI; MGI:2444417; Sh3tc2.
DR VEuPathDB; HostDB:ENSMUSG00000045629; -.
DR eggNOG; ENOG502R9YA; Eukaryota.
DR GeneTree; ENSGT00530000063812; -.
DR HOGENOM; CLU_004832_0_0_1; -.
DR InParanoid; Q80VA5; -.
DR OMA; HLETMYL; -.
DR OrthoDB; 39940at2759; -.
DR PhylomeDB; Q80VA5; -.
DR TreeFam; TF333167; -.
DR BioGRID-ORCS; 225608; 2 hits in 76 CRISPR screens.
DR ChiTaRS; Sh3tc2; mouse.
DR PRO; PR:Q80VA5; -.
DR Proteomes; UP000000589; Chromosome 18.
DR RNAct; Q80VA5; protein.
DR Bgee; ENSMUSG00000045629; Expressed in placenta labyrinth and 93 other tissues.
DR ExpressionAtlas; Q80VA5; baseline and differential.
DR Genevisible; Q80VA5; MM.
DR GO; GO:0031410; C:cytoplasmic vesicle; IDA:MGI.
DR GO; GO:0005886; C:plasma membrane; IDA:MGI.
DR GO; GO:0055037; C:recycling endosome; IBA:GO_Central.
DR GO; GO:0022011; P:myelination in peripheral nervous system; IMP:MGI.
DR GO; GO:0032287; P:peripheral nervous system myelin maintenance; IMP:MGI.
DR GO; GO:1901184; P:regulation of ERBB signaling pathway; IMP:MGI.
DR GO; GO:0033157; P:regulation of intracellular protein transport; IMP:MGI.
DR Gene3D; 1.25.40.10; -; 2.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR042772; SH3TC1/SH3TC2.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR22647; PTHR22647; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF07653; SH3_2; 1.
DR Pfam; PF13181; TPR_8; 1.
DR SMART; SM00326; SH3; 2.
DR SMART; SM00028; TPR; 6.
DR SUPFAM; SSF48452; SSF48452; 4.
DR SUPFAM; SSF50044; SSF50044; 2.
DR PROSITE; PS50002; SH3; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome; Repeat; SH3 domain; TPR repeat.
FT CHAIN 1..1289
FT /note="SH3 domain and tetratricopeptide repeat-containing
FT protein 2"
FT /id="PRO_0000106357"
FT DOMAIN 176..239
FT /note="SH3 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT DOMAIN 267..330
FT /note="SH3 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT REPEAT 529..562
FT /note="TPR 1"
FT REPEAT 758..791
FT /note="TPR 2"
FT REPEAT 837..870
FT /note="TPR 3"
FT REPEAT 1002..1038
FT /note="TPR 4"
FT REPEAT 1085..1119
FT /note="TPR 5"
FT REPEAT 1120..1153
FT /note="TPR 6"
FT REPEAT 1167..1200
FT /note="TPR 7"
FT REPEAT 1211..1245
FT /note="TPR 8"
FT REGION 393..442
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 408..432
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..407
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_009887"
FT VAR_SEQ 130..156
FT /note="YVSICLEHLFFDHTYWLNSRLVDDTEI -> MPWVGGGEHLSPSSRLVEPDT
FT GELVCL (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_009888"
FT VAR_SEQ 157..1289
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_009889"
FT VAR_SEQ 959..1001
FT /note="SQLQVTKSLCHFYSSVSPNPDACITYHEHWLALAQQLRDREME -> TRCPR
FT TPMRALPIMNTGWPWLSNSGIGRWRDSYWSPLGSFIGT (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_009890"
FT VAR_SEQ 1002..1289
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_009891"
FT VAR_SEQ 1020..1289
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_009892"
SQ SEQUENCE 1289 AA; 145144 MW; E96C52181ADD9936 CRC64;
MGGCFCIPGE RSLPWGPGKE GSSKDPPGLA EDTSSLENKR KCFLPQNMTQ DLVLSFCVKS
RSRRCVNAAL QEAARRRLWA LENEAQEVHA LFKDLSARLV SVQSQKDQFL ITFKTLEEIW
KFSTYLNLGY VSICLEHLFF DHTYWLNSRL VDDTEIQVSV DDNHLENIYL GLLLQEGHFF
CRAVCSVAQP ADKEGEYLTL CKNELISVLS GGESECEAMS LVTGQRGLVP MSALEPLPVP
FHQWFLKNHP GICGLPRKRD WTGSGQIGRG RCKALMDYEQ EERDELCFLQ GESIDVIGFV
IPGLQWFIGK SVSSGEVGFV PTRSIDLDSC SPMSKNSAFF SDEERSSLWS PGSERKAECS
GFLCSLAHTD ITSIYRLSEF EAIQNLQNDL SASQPEGFRE ARSGGTWMER QTIGSRRSSG
SGDSSPEEDE LISASSDSYH LPEPEDLDDP ELFMDLSTSL EEDDVEHFAP ILAFLDHEGY
TDHFKSLYDF SFSFLTSSFY SFSEEDELVA YLETSRKWAK MSHMTWAHAR LCFLLGRLSI
RKTKLSQARV YFEEAIRVLD GAFEDLSLVA ALYINLAAIY LRQRLRHKGP TLLEKAGALL
ACLPDHEFST KNELDVVTYV LRQGIVVGSG LLEARSCFLA IRLLLSLGRH EEVVPFAERL
QLLSGHPPAS EATATMLSSL YDKKYLPHLA VASVQKRGPQ SARGMSLSIW QAYLVLQNAT
KILGVPSSNW CEVSALACPT LRQALAACEE LSDQDIQRTL CLILSKMYLQ HQSPDGSVHY
LSQAHVLGKL LGEEEAFESS LCLAWAYLLG RQTEKALEIL EPLLCSLRET ECVTQRGVVH
NLLGLAFEDE GRTSRAAKSY LRALIRAREM GNIRNQAVSM ANLGHLTLKS CMQQSARGYL
LQAVRLYSEL QASKETDMEL VQVLLWLGQA SVSGHQLVHS RLCYEMALLF GLRHQHLSSQ
LQVTKSLCHF YSSVSPNPDA CITYHEHWLA LAQQLRDREM EGQLLESLGQ LYRNLNTSRS
LRRSLACIKE SLRIFVDLGE RDKAAEAWLG AGRLHYLMQE DELVELYLQE AIQTALRSEE
PSLALKLYEE AGDVFFNGTR HRHRAVEYYR AGAVPLARRM KALRTELRIF NKLTELQISL
EGYEKALEFA TLAARLSVLT GDQKQELVAF HRLATVYFSL NMYEMAEDCY LKTLSLCPPW
LQSPKEALYY AKVYCRLGRL TFYQLKDAHD ATEYFLLALA AAVLMGDEEL QNTIKNRLDS
ICQSPLWHSN PFGCSSERAR WLSGGSLAL
