S40A1_DANRE
ID S40A1_DANRE Reviewed; 562 AA.
AC Q9I9R3; Q3B729; Q7ZZ51; Q8AW23; Q8AW28; Q8JFW0;
DT 07-JUN-2004, integrated into UniProtKB/Swiss-Prot.
DT 07-JUN-2004, sequence version 2.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Solute carrier family 40 member 1;
DE AltName: Full=Ferroportin-1;
GN Name=slc40a1; Synonyms=fpn1, slc39a1;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Kidney;
RX PubMed=10693807; DOI=10.1038/35001596;
RA Donovan A., Brownlie A., Zhou Y., Shepard J., Pratt S.J., Moynihan J.,
RA Paw B.H., Drejer A., Barut B., Zapata A., Law T.C., Brugnara C.,
RA Lux S.E. IV, Pinkus G.S., Pinkus J.L., Kingsley P.D., Palis J.,
RA Fleming M.D., Andrews N.C., Zon L.I.;
RT "Positional cloning of zebrafish ferroportin1 identifies a conserved
RT vertebrate iron exporter.";
RL Nature 403:776-781(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-251.
RC TISSUE=Heart;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be involved in iron export and also in transfer of iron
CC between maternal and fetal circulation.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in the yolk sac and placenta.
CC -!- SIMILARITY: Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A
CC subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI07846.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF226612; AAF36695.1; -; mRNA.
DR EMBL; AL591593; CAD43474.1; -; Genomic_DNA.
DR EMBL; AL672145; CAD58776.1; -; Genomic_DNA.
DR EMBL; AL672118; CAD52128.1; -; Genomic_DNA.
DR EMBL; AL731861; CAD61076.1; -; Genomic_DNA.
DR EMBL; BC107845; AAI07846.1; ALT_SEQ; mRNA.
DR RefSeq; NP_571704.1; NM_131629.1.
DR AlphaFoldDB; Q9I9R3; -.
DR SMR; Q9I9R3; -.
DR STRING; 7955.ENSDARP00000000250; -.
DR TCDB; 2.A.100.1.7; the ferroportin (fpn) family.
DR PaxDb; Q9I9R3; -.
DR GeneID; 58153; -.
DR KEGG; dre:58153; -.
DR CTD; 30061; -.
DR ZFIN; ZDB-GENE-000511-8; slc40a1.
DR eggNOG; KOG2601; Eukaryota.
DR InParanoid; Q9I9R3; -.
DR OrthoDB; 334057at2759; -.
DR PhylomeDB; Q9I9R3; -.
DR Reactome; R-DRE-425410; Metal ion SLC transporters.
DR Reactome; R-DRE-917937; Iron uptake and transport.
DR PRO; PR:Q9I9R3; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0016323; C:basolateral plasma membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; ISS:ZFIN.
DR GO; GO:0005381; F:iron ion transmembrane transporter activity; IDA:ZFIN.
DR GO; GO:0017046; F:peptide hormone binding; IBA:GO_Central.
DR GO; GO:0030282; P:bone mineralization; IMP:ZFIN.
DR GO; GO:0006879; P:cellular iron ion homeostasis; IMP:ZFIN.
DR GO; GO:0035162; P:embryonic hemopoiesis; IMP:ZFIN.
DR GO; GO:0042541; P:hemoglobin biosynthetic process; IMP:ZFIN.
DR GO; GO:0055072; P:iron ion homeostasis; IBA:GO_Central.
DR GO; GO:0034755; P:iron ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0006826; P:iron ion transport; IMP:ZFIN.
DR GO; GO:0043362; P:nucleate erythrocyte maturation; IMP:ZFIN.
DR GO; GO:0046688; P:response to copper ion; IDA:ZFIN.
DR GO; GO:0010039; P:response to iron ion; IDA:ZFIN.
DR CDD; cd17480; MFS_SLC40A1_like; 1.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR009716; Ferroportin-1.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR11660; PTHR11660; 1.
DR Pfam; PF06963; FPN1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
PE 2: Evidence at transcript level;
KW Ion transport; Iron; Iron transport; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..562
FT /note="Solute carrier family 40 member 1"
FT /id="PRO_0000191313"
FT TRANSMEM 56..76
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 93..113
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 123..143
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 185..205
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 301..321
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 337..357
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 367..387
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 443..463
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 485..505
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 510..530
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 134
FT /note="I -> V (in Ref. 3; AAI07846)"
FT /evidence="ECO:0000305"
FT CONFLICT 272
FT /note="P -> T (in Ref. 2; CAD52128/CAD58776)"
FT /evidence="ECO:0000305"
FT CONFLICT 400
FT /note="E -> K (in Ref. 1; AAF36695)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 562 AA; 61761 MW; 35CB30971553718F CRC64;
MDSPASKKPR CERFREFFKS AKFLIYVGHA LSTWGDRMWN FAVAVFLVEL YGNSLLLTAV
YGLVVAGSVL LLGAIIGDWV DKNPRLKVAQ TSLVVQNSAV ILCGALLMAV FQFKQQLSSM
YDGWLLTTCY IMVISIANIA NLASTAMSIT IQRDWVVVVA GDDRSKLADM NATVRIIDQL
TNILAPMLVG QIMAFGSHFI GCGFISGWNL FSMCLEYFLL WKVYQKTPAL AFKAGQKDSD
DQELKHLNIQ KEIGNTESPV EASQLMTESS EPKKDTGCCY QMAEPIRTFK DGWVAYYNQS
IFFAGMSLAF LYMTVLGFDC ITTGYAYTQG LNGSVLSLLM GASAVSGICG TVAFTWIRKK
CGLIRTGFIA GVTQLSCLTL CVASVFAPGS PFDLSVSPFE EVLRHLFGDS GSLRESPTFI
PTTEPPIQAN VTVFEEAPPV ESYMSVGLLF AGVIAARVGL WSFDLTVTQL IQENVIESER
GVINGVQNSM NYLLDLLHFI MVILAPNPEA FGLLVIISVS FVAMGHMMYF RFAYKSLGSR
LFLFCSPEQK PDPNIPSLPN SV
